ID Peer AC CVCL_1913 SY PEER DR BTO; BTO_0001959 DR CLO; CLO_0008416 DR CLO; CLO_0050081 DR EFO; EFO_0022420 DR CLDB; cl4115 DR ArrayExpress; E-MTAB-2770 DR BioSample; SAMN01821654 DR BioSample; SAMN03472523 DR BioSample; SAMN03473496 DR BioSample; SAMN10988124 DR cancercelllines; CVCL_1913 DR Cell_Model_Passport; SIDM00991 DR Cosmic; 721704 DR Cosmic; 801731 DR Cosmic; 933548 DR Cosmic; 998727 DR Cosmic; 1037685 DR Cosmic; 1115597 DR Cosmic; 1118460 DR Cosmic; 1130238 DR Cosmic; 1281382 DR Cosmic; 1330494 DR Cosmic; 1375591 DR Cosmic; 1524813 DR Cosmic; 1641383 DR Cosmic; 1760530 DR Cosmic; 2165707 DR Cosmic; 2361369 DR Cosmic; 2602908 DR DepMap; ACH-000519 DR DSMZ; ACC-6 DR DSMZCellDive; ACC-6 DR GEO; GSM887512 DR GEO; GSM888594 DR GEO; GSM5137737 DR IARC_TP53; 10566 DR IARC_TP53; 30193 DR JCRB; JCRB0830 DR LiGeA; CCLE_494 DR LINCS_LDP; LCL-2062 DR NCBI_Iran; C511 DR PharmacoDB; PEER_1261_2019 DR PRIDE; PXD023662 DR Progenetix; CVCL_1913 DR RCB; RCB1879 DR TKG; TKG 0377 DR Wikidata; Q2067085 RX DOI=10.1016/B978-0-12-221970-2.50457-5; RX PubMed=1373528; RX PubMed=2241089; RX PubMed=2523930; RX PubMed=2985879; RX PubMed=3159941; RX PubMed=3874327; RX PubMed=6181032; RX PubMed=6582512; RX PubMed=8127147; RX PubMed=8547074; RX PubMed=8641406; RX PubMed=9290701; RX PubMed=9933131; RX PubMed=10071127; RX PubMed=10739008; RX PubMed=11226526; RX PubMed=14768698; RX PubMed=15361874; RX PubMed=15472075; RX PubMed=17170727; RX PubMed=17308084; RX PubMed=22460905; RX PubMed=22675565; RX PubMed=26589293; RX PubMed=30285677; RX PubMed=30629668; RX PubMed=30894373; RX PubMed=31068700; RX PubMed=35354797; WW Info; T-ALL cell lines db; -; https://humantallcelllines.wordpress.com/2016/07/06/peer/ WW Info; Wikipedia; -; https://de.wikipedia.org/wiki/Peer_(Zelllinie) CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Population: Caucasian. CC Doubling time: ~50-60 hours (DSMZ=ACC-6); ~40-50 hours (Note=Lot 06202003), ~39 hours (Note=Lot 10012019) (JCRB=JCRB0830). CC HLA typing: A*23:01,24:02; B*35:02,44:03; C*04:01,04:01; DQA1*01:02,01:02 (PubMed=26589293). CC Microsatellite instability: Stable (MSS) (PubMed=10739008; PubMed=11226526). CC Sequence variation: Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:8064; NUP214; Name(s)=NUP214-ABL1; Note=NUP214 exon 34 fused to ABL1 exon 2 (PubMed=15361874; PubMed=35354797; DSMZ=ACC-6). CC Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (PubMed=22675565; DepMap=ACH-000519). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr163Cys (c.488A>G); ClinVar=VCV000127814; Zygosity=Heterozygous (PubMed=10071127; PubMed=22675565; DepMap=ACH-000519). CC Omics: Genomics; Whole exome sequencing. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=3.73%; Native American=0.87%; East Asian, North=2.76%; East Asian, South=0.35%; South Asian=9.54%; European, North=10.64%; European, South=72.11% (PubMed=30894373). CC Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. CC Cell type: T-cell; CL=CL_0000084. ST Source(s): DSMZ=ACC-6; JCRB=JCRB0830; RCB=RCB1879; TKG=TKG 0377 ST Amelogenin: X ST CSF1PO: 12 ST D13S317: 11,14 (DSMZ=ACC-6; RCB=RCB1879; TKG=TKG 0377) ST D13S317: 14 (JCRB=JCRB0830) ST D16S539: 8,13 ST D18S51: 11,15 ST D19S433: 13 ST D21S11: 28,33.2 ST D2S1338: 20 ST D3S1358: 15 ST D5S818: 12 ST D7S820: 10,12 ST D8S1179: 15 ST FGA: 24 ST Penta D: 11,13 ST Penta E: 13,15 ST TH01: 7,8 ST TPOX: 11 ST vWA: 17,18 DI NCIt; C7953; Childhood T acute lymphoblastic leukemia DI ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Female AG 4Y CA Cancer cell line DT Created: 04-04-12; Last updated: 14-08-25; Version: 41 CH CVCL_1081 ! BE-13 CH CVCL_E8UC ! ICLU-T // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=8127147; RA Heyman, Mats RA Grander, Dan RA Brondum-Nielsen, Karen RA Cederblad, Britta RA Liu, Yie RA Xu, Bo RA Einhorn, Stefan RT "Interferon system defects in malignant T-cells."; RL Leukemia 8:425-434(1994). // RX PubMed=10071127; DOI=10.1016/S0145-2126(98)00146-5; RA Kawamura, Machiko RA Ohnishi, Hiroaki RA Guo, Shu-Xia RA Sheng, Xiao-Ming RA Minegishi, Masayoshi RA Hanada, Ryoji RA Horibe, Keizo RA Hongo, Teruaki RA Kaneko, Yasuhiko RA Bessho, Fumio RA Yanagisawa, Masayoshi RA Sekiya, Takao RA Hayashi, Yasuhide RT "Alterations of the p53, p21, p16, p15 and RAS genes in childhood RT T-cell acute lymphoblastic leukemia."; RL Leuk. Res. 23:115-126(1999). // RX PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0; RA Drexler, Hans Gunther RA Gaedicke, Gerhard RA Minowada, Jun RT "Isoenzyme studies in human leukemia-lymphoma cell lines -- 1. RT Carboxylic esterase."; RL Leuk. Res. 9:209-229(1985). // RX PubMed=17308084; DOI=10.1158/0008-5472.CAN-06-2615; RA Nagel, Stefan RA Scherr, Michaela RA Kel, Alexander RA Hornischer, Klaus RA Crawford, Gregory E. RA Kaufmann, Maren RA Meyer, Corinna RA Drexler, Hans Gunther RA MacLeod, Roderick A.F. RT "Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute RT lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation RT by PU.1 and HMGA1."; RL Cancer Res. 67:1461-1471(2007). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144; RA Uphoff, Cord C. RA Pommerenke, Claudia RA Denkmann, Sabine A. RA Drexler, Hans Gunther RT "Screening human cell lines for viral infections applying RNA-Seq data RT analysis."; RL PLoS ONE 14:e0210404.1-e0210404.22(2019). // RX PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D; RA Jia, Li-Qun RA Osada, Motonobu RA Ishioka, Chikashi RA Gamo, Makio RA Ikawa, Shuntaro RA Suzuki, Takao RA Shimodaira, Hideki RA Niitani, Tomohito RA Kudo, Toshio RA Akiyama, Mitoshi RA Kimura, Narimiti RA Matsuo, Mitsuyoshi RA Mizusawa, Hiroshi RA Tanaka, Noriho RA Koyama, Hideki RA Namba, Masayoshi RA Kanamaru, Ryunosuke RA Kuroki, Toshio RT "Screening the p53 status of human cell lines using a yeast functional RT assay."; RL Mol. Carcinog. 19:243-253(1997). // RX PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720; RA Mattes, Michael Jules RA Cordon-Cardo, Carlos RA Lewis, John L. Jr. RA Old, Lloyd John RA Lloyd, Kenneth Oliver RT "Cell surface antigens of human ovarian and endometrial carcinoma RT defined by mouse monoclonal antibodies."; RL Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984). // RX PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1; RA Drexler, Hans Gunther RA Gaedicke, Gerhard RA Minowada, Jun RT "Isoenzyme studies in human leukemia-lymphoma cell lines -- III. RT Beta-hexosaminidase (E.C. 3.2.1.30)."; RL Leuk. Res. 9:549-559(1985). // RX PubMed=2241089; RA Massaad-Massade, Liliane RA Venuat, Anne-Marie RA Remvikos, Yorghos RA Dutrillaux, Bernard RT "Revision of the chromosome anomalies of the T-cell malignant cell RT line PEER."; RL Ann. Genet. 33:76-78(1990). // RX PubMed=6181032; DOI=10.1016/0198-8859(82)90037-4; RA Rabinowitz, Ruth RA Weinstock, J. RA Margalioth, Ehud J. RA Ben-Bassat, Hannah RA Schlesinger, Michael RT "Antigens specific for human T-lymphocytes detected by xenoantisera to RT HD-MAR cells: their differential expression on various T-cell lines."; RL Hum. Immunol. 4:219-228(1982). // RX PubMed=11226526; DOI=10.1016/S0145-2126(00)00121-1; RA Inoue, Kaoru RA Kohno, Takashi RA Takakura, Satoshi RA Hayashi, Yasuhide RA Mizoguchi, Hideaki RA Yokota, Jun RT "Corrigendum to 'Frequent microsatellite instability and BAX mutations RT in T cell acute lymphoblastic leukemia cell lines' Leukemia Research 24 RT (2000), 255-262."; RL Leuk. Res. 25:275-278(2001). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura Eleanor RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=17170727; DOI=10.1038/sj.leu.2404486; RA Sandberg, Yorick RA Verhaaf, Brenda RA van Gastel-Mol, Ellen J. RA Wolvers-Tettero, Ingrid L.M. RA De Vos, John RA MacLeod, Roderick A.F. RA Noordzij, Jeroen G. RA Dik, Willem A. RA van Dongen, Jacobus Johannes Maria RA Langerak, Anton W. RT "Human T-cell lines with well-defined T-cell receptor gene RT rearrangements as controls for the BIOMED-2 multiplex polymerase chain RT reaction tubes."; RL Leukemia 21:230-237(2007). // RX PubMed=1373528; RA Duan, Da-Shuhn RA Smith, Wayne RA Sadee, Wolfgang RA Cowan, Morton J. RT "Characterization of three T-lymphoid cell lines with distinct RT sensitivities to deoxyadenosine plus deoxycoformycin."; RL Thymus 19:1-11(1992). // RX PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x; RA Drexler, Hans Gunther RA Gaedicke, Gerhard RA Minowada, Jun RT "Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid RT phosphatase."; RL Leuk. Res. 9:537-548(1985). // RX PubMed=8641406; DOI=10.1111/j.1600-0609.1996.tb00721.x; RA Borgonovo-Brandter, Laura RA Heyman, Mats RA Rasool, Omid RA Liu, Yie RA Grander, Dan RA Einhorn, Stefan RT "p16INK4/p15INK4B gene inactivation is a frequent event in malignant RT T-cell lines."; RL Eur. J. Haematol. 56:313-318(1996). // RX PubMed=14768698; DOI=10.1002/ijc.2910250604; RA Ravid, Zohar RA Goldblum, Natan RA Zaizov Marx, Rina RA Schlesinger, Michael RA Kertes, Tamar RA Minowada, Jun RA Verbi, Winston RA Greaves, Melvyn Francis RT "Establishment and characterization of a new leukaemic T-cell line RT (Peer) with an unusual phenotype."; RL Int. J. Cancer 25:705-710(1980). // RX PubMed=8547074; DOI=10.1111/j.1365-2141.1995.tb05302.x; RA Siebert, Reiner RA Willers, Christoph P. RA Schramm, Alexander RA Fossa, Alexander RA Dresen, Irina M. Gana RA Uppenkamp, Michael J. RA Nowrousian, Mohammad Resa RA Seeber, Siegfried RA Opalka, Bertram RT "Homozygous loss of the MTS1/p16 and MTS2/p15 genes in lymphoma and RT lymphoblastic leukaemia cell lines."; RL Br. J. Haematol. 91:350-354(1995). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=15361874; DOI=10.1038/ng1425; RA Graux, Carlos RA Cools, Jan RA Melotte, Cindy RA Quentmeier, Hilmar RA Ferrando, Adolfo A. RA Levine, Ross RA Vermeesch, Joris R. RA Stul, Michel RA Dutta, Binita RA Boeckx, Nancy RA Bosly, Andre RA Heimann, Pierre RA Uyttebroeck, Anne RA Mentens, Nicole RA Somers, Riet RA MacLeod, Roderick A.F. RA Drexler, Hans Gunther RA Look, Alfred Thomas RA Gilliland, Dwight Gary RA Michaux, Lucienne RA Vandenberghe, Peter RA Wlodarska, Iwona RA Marynen, Peter RA Hagemeijer, Anne RT "Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute RT lymphoblastic leukemia."; RL Nat. Genet. 36:1084-1089(2004). // RX PubMed=9933131; DOI=10.1016/S0145-2126(98)00133-7; RA Burger, Renate RA Hansen-Hagge, Thomas E. RA Drexler, Hans Gunther RA Gramatzki, Martin RT "Heterogeneity of T-acute lymphoblastic leukemia (T-ALL) cell lines: RT suggestion for classification by immunophenotype and T-cell receptor RT studies."; RL Leuk. Res. 23:19-27(1999). // RX PubMed=22675565; DOI=10.1371/journal.pone.0038463; PMCID=PMC3366948; RA Atak, Zeynep Kalender RA De Keersmaecker, Kim RA Gianfelici, Valentina RA Geerdens, Ellen RA Vandepoel, Roel RA Pauwels, Daphnie RA Porcu, Michael RA Lahortiga, Idoya RA Brys, Vanessa RA Dirks, Wilhelm Gerhard RA Quentmeier, Hilmar RA Cloos, Jacqueline RA Cuppens, Harry RA Uyttebroeck, Anne RA Vandenberghe, Peter RA Cools, Jan RA Aerts, Stein RT "High accuracy mutation detection in leukemia on a selected panel of RT cancer genes."; RL PLoS ONE 7:e38463.1-e38463.11(2012). // RX DOI=10.1016/B978-0-12-221970-2.50457-5; RA Drexler, Hans Gunther RT "The leukemia-lymphoma cell line factsbook."; RL (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001). // RX PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4; RA Inoue, Kaoru RA Kohno, Takashi RA Takakura, Satoshi RA Hayashi, Yasuhide RA Mizoguchi, Hideaki RA Yokota, Jun RT "Frequent microsatellite instability and BAX mutations in T cell acute RT lymphoblastic leukemia cell lines."; RL Leuk. Res. 24:255-262(2000). // RX PubMed=15472075; DOI=10.1126/science.1102160; RA Weng, Andrew P. RA Ferrando, Adolfo A. RA Lee, Woojoong RA Morris, John P. 4th RA Silverman, Lewis B. RA Sanchez-Irizarry, Cheryll RA Blacklow, Stephen Charles RA Look, Alfred Thomas RA Aster, Jon Christopher RT "Activating mutations of NOTCH1 in human T cell acute lymphoblastic RT leukemia."; RL Science 306:269-271(2004). // RX PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786; RA Tan, Kar-Tong RA Ding, Ling-Wen RA Sun, Qiao-Yang RA Lao, Zhen-Tang RA Chien, Wenwen RA Ren, Xi RA Xiao, Jin-Fen RA Loh, Xin-Yi RA Xu, Liang RA Lill, Michael RA Mayakonda, Anand RA Lin, De-Chen RA Yang, Henry He RA Koeffler, Harold Phillip RT "Profiling the B/T cell receptor repertoire of lymphocyte derived cell RT lines."; RL BMC Cancer 18:940.1-940.13(2018). // RX PubMed=35354797; DOI=10.1038/s41467-022-29224-5; PMCID=PMC8967900; RA Leo, Isabelle Rose RA Aswad, Luay RA Stahl, Matthias RA Kunold, Elena RA Post, Frederik RA Erkers, Tom RA Struyf, Nona RA Mermelekas, Georgios RA Joshi, Rubin Narayan RA Gracia-Villacampa, Eva RA Ostling, Paivi RA Kallioniemi, Olli-Pekka RA Pokrovskaja Tamm, Katja RA Siavelis, Ioannis RA Lehtio, Janne RA Vesterlund, Mattias RA Jafari, Rozbeh RT "Integrative multi-omics and drug response profiling of childhood RT acute lymphoblastic leukemia cell lines."; RL Nat. Commun. 13:1691.1-1691.19(2022). // RX PubMed=2523930; DOI=10.4049/jimmunol.142.10.3634; RA de Waal Malefyt, Rene RA Alarcon, Balbino RA Yssel, Hans RA Sancho, Jaime RA Miyajima, Atsushi RA Terhorst, Cox Pieter RA Spits, Hergen RA de Vries, Jan E. RT "Introduction of T cell receptor (TCR)-alpha cDNA has differential RT effects on TCR-gamma delta/CD3 expression by PEER and Lyon-1 cells."; RL J. Immunol. 142:3634-3642(1989). //