Cellosaurus logo
expasy logo

Cellosaurus BE-13 (CVCL_1081)

[Text version]
Cell line name BE-13
Synonyms Be-13; BE13; Be13
Accession CVCL_1081
Resource Identification Initiative To cite this cell line use: BE-13 (RRID:CVCL_1081)
Comments Problematic cell line: Contaminated. Shown to be a Peer derivative (PubMed=12592342; PubMed=20143388). Originally thought to originate from the bone marrow of a 11 year old patient with T-ALL.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00178.
Population: Caucasian.
Doubling time: ~40-60 hours (DSMZ=ACC-396).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:8064; NUP214; Name(s)=NUP214-ABL1; Note=NUP214 exon 34 fused to ABL1 exon 2 (PubMed=15361874; PubMed=35354797).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Unspecified (PubMed=22675565).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr163Cys (c.488A>G); ClinVar=VCV000127814; Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP=906763).
Genome ancestry Source: PubMed=30894373

Origin% genome
African3.02
Native American1.38
East Asian, North0
East Asian, South1.18
South Asian10.89
European, North13.65
European, South69.88
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1913 (Peer)
Sex of cell Female
Age at sampling 4Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=906763; DSMZ=ACC-396

Markers:
AmelogeninX
CSF1PO12
D2S133820
D3S135815
D5S81812
D7S82010,12
D8S117915
D13S31711,14
D16S5398,13
D18S5111,15
D19S43313,17
D21S1128,33.2
FGA24
Penta D11,13
Penta E12,15
TH017,8
TPOX11
vWA17,18

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

CLPUB00700
Naomi Galili, Uri Galili, Zohar Ravid, Michael Schlesinger, Natan Goldblum;
Induction of differentiation with phorbol ester in a human T cell line (Be13) expressing both prothymocyte and thymocyte characteristics.
Hum. Lymph. Diff. 1:123-130(1981)

PubMed=6181032; DOI=10.1016/0198-8859(82)90037-4
Ruth Rabinowitz, J. Weinstock, Ehud J. Margalioth, Hannah Ben-Bassat, Michael Schlesinger;
Antigens specific for human T-lymphocytes detected by xenoantisera to HD-MAR cells: their differential expression on various T-cell lines.
Hum. Immunol. 4:219-228(1982)

PubMed=6331881
Uri Galili, Aviva Peleg, Yoram Milner, Naomi Galili;
Be13, a human T-leukemia cell line highly sensitive to dexamethasone-induced cytolysis.
Cancer Res. 44:4594-4601(1984)

PubMed=2144611; DOI=10.1128/mcb.10.10.5502-5509.1990; PMCID=PMC361264
Jian Cheng, Martin Haas;
Frequent mutations in the p53 tumor suppressor gene in human leukemia T-cell lines.
Mol. Cell. Biol. 10:5502-5509(1990)

PubMed=1727382
Jian Cheng, Jiing-Kuan Yee, Jo Yeargin, Theodore Friedmann, Martin Haas;
Suppression of acute lymphoblastic leukemia by the human wild-type p53 gene.
Cancer Res. 52:222-226(1992)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=12592342; DOI=10.1038/sj.leu.2402799
Hans Gunther Drexler, Wilhelm Gerhard Dirks, Yoshinobu Matsuo, Roderick A.F. MacLeod;
False leukemia-lymphoma cell lines: an update on over 500 cell lines.
Leukemia 17:416-426(2003)

PubMed=15361874; DOI=10.1038/ng1425
Carlos Graux, Jan Cools, Cindy Melotte, Hilmar Quentmeier, Adolfo A. Ferrando, Ross Levine, Joris R. Vermeesch, Michel Stul, Binita Dutta, Nancy Boeckx, Andre Bosly ...Show all 24 authors... , Pierre Heimann, Anne Uyttebroeck, Nicole Mentens, Riet Somers, Roderick A.F. MacLeod, Hans Gunther Drexler, Alfred Thomas Look, Dwight Gary Gilliland, Lucienne Michaux, Peter Vandenberghe, Iwona Wlodarska, Peter Marynen, Anne Hagemeijer; Show fewer authors
Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia.
Nat. Genet. 36:1084-1089(2004)

PubMed=15472075; DOI=10.1126/science.1102160
Andrew P. Weng, Adolfo A. Ferrando, Woojoong Lee, John P. Morris 4th, Lewis B. Silverman, Cheryll Sanchez-Irizarry, Stephen Charles Blacklow, Alfred Thomas Look, Jon Christopher Aster;
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
Science 306:269-271(2004)

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22675565; DOI=10.1371/journal.pone.0038463; PMCID=PMC3366948
Zeynep Kalender Atak, Kim De Keersmaecker, Valentina Gianfelici, Ellen Geerdens, Roel Vandepoel, Daphnie Pauwels, Michael Porcu, Idoya Lahortiga, Vanessa Brys, Wilhelm Gerhard Dirks, Hilmar Quentmeier ...Show all 17 authors... , Jacqueline Cloos, Harry Cuppens, Anne Uyttebroeck, Peter Vandenberghe, Jan Cools, Stein Aerts; Show fewer authors
High accuracy mutation detection in leukemia on a selected panel of cancer genes.
PLoS ONE 7:e38463.1-e38463.11(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35354797; DOI=10.1038/s41467-022-29224-5; PMCID=PMC8967900
Isabelle Rose Leo, Luay Aswad, Matthias Stahl, Elena Kunold, Frederik Post, Tom Erkers, Nona Struyf, Georgios Mermelekas, Rubin Narayan Joshi, Eva Gracia-Villacampa, Paivi Ostling ...Show all 17 authors... , Olli-Pekka Kallioniemi, Katja Pokrovskaja Tamm, Ioannis Siavelis, Janne Lehtio, Mattias Vesterlund, Rozbeh Jafari; Show fewer authors
Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.
Nat. Commun. 13:1691.1-1691.19(2022)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-396
Cell line databases/resources CLO; CLO_0001921
cancercelllines; CVCL_1081
Cell_Model_Passport; SIDM01245
Cosmic-CLP; 906763
DepMap; ACH-002216
DSMZCellDive; ACC-396
LINCS_LDP; LCL-1044
Biological sample resources BioSample; SAMN03151896
Chemistry resources ChEMBL-Cells; CHEMBL3308184
ChEMBL-Targets; CHEMBL2366303
GDSC; 906763
PharmacoDB; BE13_84_2019
PubChem_Cell_line; CVCL_1081
Encyclopedic resources Wikidata; Q54795852
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1669613
GEO; GSM5137751
Polymorphism and mutation databases Cosmic; 906763
Cosmic; 1115589
Cosmic; 1151773
Cosmic; 1330495
Cosmic; 1760518
Cosmic; 2165705
Cosmic; 2602909
IARC_TP53; 21650
Proteomic databases PRIDE; PXD023662
PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number43