ID   BE-13
AC   CVCL_1081
SY   Be-13; BE13; Be13
DR   CLO; CLO_0001921
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-3610
DR   BioSample; SAMN03151896
DR   cancercelllines; CVCL_1081
DR   Cell_Model_Passport; SIDM01245
DR   ChEMBL-Cells; CHEMBL3308184
DR   ChEMBL-Targets; CHEMBL2366303
DR   Cosmic; 906763
DR   Cosmic; 1115589
DR   Cosmic; 1151773
DR   Cosmic; 1330495
DR   Cosmic; 1760518
DR   Cosmic; 2165705
DR   Cosmic; 2602909
DR   Cosmic-CLP; 906763
DR   DepMap; ACH-002216
DR   DSMZ; ACC-396
DR   DSMZCellDive; ACC-396
DR   EGA; EGAS00001000978
DR   GDSC; 906763
DR   GEO; GSM1669613
DR   GEO; GSM5137751
DR   IARC_TP53; 21650
DR   LINCS_LDP; LCL-1044
DR   PharmacoDB; BE13_84_2019
DR   PRIDE; PXD023662
DR   PRIDE; PXD030304
DR   PubChem_Cell_line; CVCL_1081
DR   Wikidata; Q54795852
RX   CelloPub=CLPUB00700;
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=1727382;
RX   PubMed=2144611;
RX   PubMed=6181032;
RX   PubMed=6331881;
RX   PubMed=12592342;
RX   PubMed=15361874;
RX   PubMed=15472075;
RX   PubMed=20143388;
RX   PubMed=20164919;
RX   PubMed=22675565;
RX   PubMed=27397505;
RX   PubMed=30894373;
RX   PubMed=35354797;
RX   PubMed=35839778;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a Peer derivative (PubMed=12592342; PubMed=20143388). Originally thought to originate from the bone marrow of a 11 year old patient with T-ALL.
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00178.
CC   Population: Caucasian.
CC   Doubling time: ~40-60 hours (DSMZ=ACC-396).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:8064; NUP214; Name(s)=NUP214-ABL1; Note=NUP214 exon 34 fused to ABL1 exon 2 (PubMed=15361874; PubMed=35354797).
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Unspecified (PubMed=22675565).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr163Cys (c.488A>G); ClinVar=VCV000127814; Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP=906763).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=3.02%; Native American=1.38%; East Asian, North=0%; East Asian, South=1.18%; South Asian=10.89%; European, North=13.65%; European, South=69.88% (PubMed=30894373).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
ST   Source(s): Cosmic-CLP=906763; DSMZ=ACC-396
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 11,14
ST   D16S539: 8,13
ST   D18S51: 11,15
ST   D19S433: 13,17
ST   D21S11: 28,33.2
ST   D2S1338: 20
ST   D3S1358: 15
ST   D5S818: 12
ST   D7S820: 10,12
ST   D8S1179: 15
ST   FGA: 24
ST   Penta D: 11,13
ST   Penta E: 12,15
ST   TH01: 7,8
ST   TPOX: 11
ST   vWA: 17,18
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1913 ! Peer
SX   Female
AG   4Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 43
//
RX   PubMed=6331881;
RA   Galili, Uri
RA   Peleg, Aviva
RA   Milner, Yoram
RA   Galili, Naomi
RT   "Be13, a human T-leukemia cell line highly sensitive to
RT   dexamethasone-induced cytolysis.";
RL   Cancer Res. 44:4594-4601(1984).
//
RX   PubMed=22675565; DOI=10.1371/journal.pone.0038463; PMCID=PMC3366948;
RA   Atak, Zeynep Kalender
RA   De Keersmaecker, Kim
RA   Gianfelici, Valentina
RA   Geerdens, Ellen
RA   Vandepoel, Roel
RA   Pauwels, Daphnie
RA   Porcu, Michael
RA   Lahortiga, Idoya
RA   Brys, Vanessa
RA   Dirks, Wilhelm Gerhard
RA   Quentmeier, Hilmar
RA   Cloos, Jacqueline
RA   Cuppens, Harry
RA   Uyttebroeck, Anne
RA   Vandenberghe, Peter
RA   Cools, Jan
RA   Aerts, Stein
RT   "High accuracy mutation detection in leukemia on a selected panel of
RT   cancer genes.";
RL   PLoS ONE 7:e38463.1-e38463.11(2012).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler, Hans Gunther
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=12592342; DOI=10.1038/sj.leu.2402799;
RA   Drexler, Hans Gunther
RA   Dirks, Wilhelm Gerhard
RA   Matsuo, Yoshinobu
RA   MacLeod, Roderick A.F.
RT   "False leukemia-lymphoma cell lines: an update on over 500 cell
RT   lines.";
RL   Leukemia 17:416-426(2003).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis, Amanda
RA   Theodosopoulos, George
RA   Atkin, Isobel
RA   Drexler, Hans Gunther
RA   Kohara, Arihiro
RA   MacLeod, Roderick A.F.
RA   Masters, John R.W.
RA   Nakamura, Yukio
RA   Reid, Yvonne A.
RA   Reddel, Roger Robert
RA   Freshney, Robert Ian
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113;
RA   Bignell, Graham Robert
RA   Greenman, Christopher D.
RA   Davies, Helen R.
RA   Butler, Adam P.
RA   Edkins, Sarah
RA   Andrews, Jenny M.
RA   Buck, Gemma
RA   Chen, Lina
RA   Beare, David
RA   Latimer, Calli
RA   Widaa, Sara
RA   Hinton, Jonathan
RA   Fahey, Ciara
RA   Fu, Bei-Yuan
RA   Swamy, Sajani
RA   Dalgliesh, Gillian L.
RA   Teh, Bin Tean
RA   Deloukas, Panos
RA   Yang, Feng-Tang
RA   Campbell, Peter J.
RA   Futreal, P. Andrew
RA   Stratton, Michael Rudolf
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=6181032; DOI=10.1016/0198-8859(82)90037-4;
RA   Rabinowitz, Ruth
RA   Weinstock, J.
RA   Margalioth, Ehud J.
RA   Ben-Bassat, Hannah
RA   Schlesinger, Michael
RT   "Antigens specific for human T-lymphocytes detected by xenoantisera to
RT   HD-MAR cells: their differential expression on various T-cell lines.";
RL   Hum. Immunol. 4:219-228(1982).
//
RX   PubMed=15472075; DOI=10.1126/science.1102160;
RA   Weng, Andrew P.
RA   Ferrando, Adolfo A.
RA   Lee, Woojoong
RA   Morris, John P. 4th
RA   Silverman, Lewis B.
RA   Sanchez-Irizarry, Cheryll
RA   Blacklow, Stephen Charles
RA   Look, Alfred Thomas
RA   Aster, Jon Christopher
RT   "Activating mutations of NOTCH1 in human T cell acute lymphoblastic
RT   leukemia.";
RL   Science 306:269-271(2004).
//
RX   CelloPub=CLPUB00700;
RA   Galili, Naomi
RA   Galili, Uri
RA   Ravid, Zohar
RA   Schlesinger, Michael
RA   Goldblum, Natan
RT   "Induction of differentiation with phorbol ester in a human T cell line
RT   (Be13) expressing both prothymocyte and thymocyte characteristics.";
RL   Hum. Lymph. Diff. 1:123-130(1981).
//
RX   PubMed=1727382;
RA   Cheng, Jian
RA   Yee, Jiing-Kuan
RA   Yeargin, Jo
RA   Friedmann, Theodore
RA   Haas, Martin
RT   "Suppression of acute lymphoblastic leukemia by the human wild-type
RT   p53 gene.";
RL   Cancer Res. 52:222-226(1992).
//
RX   PubMed=2144611; DOI=10.1128/mcb.10.10.5502-5509.1990; PMCID=PMC361264;
RA   Cheng, Jian
RA   Haas, Martin
RT   "Frequent mutations in the p53 tumor suppressor gene in human leukemia
RT   T-cell lines.";
RL   Mol. Cell. Biol. 10:5502-5509(1990).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=15361874; DOI=10.1038/ng1425;
RA   Graux, Carlos
RA   Cools, Jan
RA   Melotte, Cindy
RA   Quentmeier, Hilmar
RA   Ferrando, Adolfo A.
RA   Levine, Ross
RA   Vermeesch, Joris R.
RA   Stul, Michel
RA   Dutta, Binita
RA   Boeckx, Nancy
RA   Bosly, Andre
RA   Heimann, Pierre
RA   Uyttebroeck, Anne
RA   Mentens, Nicole
RA   Somers, Riet
RA   MacLeod, Roderick A.F.
RA   Drexler, Hans Gunther
RA   Look, Alfred Thomas
RA   Gilliland, Dwight Gary
RA   Michaux, Lucienne
RA   Vandenberghe, Peter
RA   Wlodarska, Iwona
RA   Marynen, Peter
RA   Hagemeijer, Anne
RT   "Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute
RT   lymphoblastic leukemia.";
RL   Nat. Genet. 36:1084-1089(2004).
//
RX   PubMed=35354797; DOI=10.1038/s41467-022-29224-5; PMCID=PMC8967900;
RA   Leo, Isabelle Rose
RA   Aswad, Luay
RA   Stahl, Matthias
RA   Kunold, Elena
RA   Post, Frederik
RA   Erkers, Tom
RA   Struyf, Nona
RA   Mermelekas, Georgios
RA   Joshi, Rubin Narayan
RA   Gracia-Villacampa, Eva
RA   Ostling, Paivi
RA   Kallioniemi, Olli-Pekka
RA   Pokrovskaja Tamm, Katja
RA   Siavelis, Ioannis
RA   Lehtio, Janne
RA   Vesterlund, Mattias
RA   Jafari, Rozbeh
RT   "Integrative multi-omics and drug response profiling of childhood
RT   acute lymphoblastic leukemia cell lines.";
RL   Nat. Commun. 13:1691.1-1691.19(2022).
//