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Cellosaurus Lu-134-A (CVCL_1387)

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Cell line name Lu-134-A
Synonyms Lu-134-a; LU-134-A; LU-134A; Lu-134A; Lu134A; LU-134; Lu-134; Lu134; NCC-c-Lu-134-A-H; Lu-134-A-H; LU-134-A-H; Lu-134-AH; LU-134-AH; Lu134-A-H; Lu134-AH; Lu134AH
Accession CVCL_1387
Secondary accession CVCL_2790
Resource Identification Initiative To cite this cell line use: Lu-134-A (RRID:CVCL_1387)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 46 hours (PubMed=3022030; PubMed=6098504); 51.9 hours (PubMed=8286010).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.6
Native American0
East Asian, North73.6
East Asian, South23.8
South Asian1.7
European, North0.3
European, South0
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_6862 (Lu-130)
Originate from same individual CVCL_1388 ! Lu-134-B
Sex of cell Male
Age at sampling 80Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=753588; JCRB=JCRB0235; RCB=RCB0466

Markers:
AmelogeninX
CSF1PO12
D5S81811
D7S82011
D13S3179
D16S5399
TH019
TPOX11
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=6098504; DOI=10.20772/cancersci1959.75.12_1089
Takeo Terasaki, Toru Kameya, Takashi Nakajima, Masaru Tsumuraya, Yukio Shimosato, Kanefusa Kato, Hiroshi Ichinose, Toshiharu Nagatsu, Tomoko Hasegawa;
Interconversion of biological characteristics of small cell lung cancer depending on culture conditions.
Gann 75:1089-1099(1984)

DOI=10.5795/jjscc.24.451
Masaru Tsumuraya, Takashi Nakajima, Takeo Terasaki, Tetsuro Kodama, Yukio Shimosato, Hisaaki Higuchi, Yoshio Uei;
Analysis of LDH isoenzyme patterns in cell lines of the small cell carcinoma (lung) and retinoblastoma.
Nihon Rinsho Saibo Gakkai Zasshi 24:451-456(1985)

PubMed=3022030; DOI=10.1093/oxfordjournals.jjco.a039144
Takeo Terasaki, Yukio Shimosato, Takashi Nakajima, Masaru Tsumuraya, Shojiroh Morinaga, Setsuo Hirohashi, Ken Yamaguchi, Kanefusa Kato, Hiroshi Ichinose, Toshiharu Nagatsu;
Changes in cell characteristics due to culture conditions in cell lines from human small cell lung cancer.
Jpn. J. Clin. Oncol. 16:203-212(1986)

PubMed=1847845; DOI=10.1007/BF00685110
Yasutsuna Sasaki, Tetsu Shinkai, Kenji Eguchi, Tomohide Tamura, Yuichiro Ohe, Tohru Ohmori, Nagahiro Saijo;
Prediction of the antitumor activity of new platinum analogs based on their ex vivo pharmacodynamics as determined by bioassay.
Cancer Chemother. Pharmacol. 27:263-270(1991)

PubMed=1312700
Yuichi Sameshima, Yoshihiro Matsuno, Setsuo Hirohashi, Yukio Shimosato, Hideaki Mizoguchi, Takashi Sugimura, Masaaki Terada, Jun Yokota;
Alterations of the p53 gene are common and critical events for the maintenance of malignant phenotypes in small-cell lung carcinoma.
Oncogene 7:451-457(1992)

PubMed=8286010
Katsuyuki Kiura, Shinobu Watarai, Takuo Shibayama, Taisuke Ohnoshi, Ikuro Kimura, Tatsuji Yasuda;
Inhibitory effects of cholera toxin on in vitro growth of human lung cancer cell lines.
Anticancer Drug Des. 8:417-428(1993)

PubMed=8263009; DOI=10.1007/BF01202192
Tatsuhiko Kashii, Yutaka Mizushima, Satoshi Monno, K. Nakagawa, M. Kobayashi;
Gene analysis of K-, H-ras, p53, and retinoblastoma susceptibility genes in human lung cancer cell lines by the polymerase chain reaction/single-strand conformation polymorphism method.
J. Cancer Res. Clin. Oncol. 120:143-148(1994)

PubMed=9413215
Hiromishi Yamane, Katsuyuki Kiura, Masahiro Tabata, Akihiro Bessho, Tadashi Tsuchida, Kinya Motoda, Akio Hiraki, Hiroshi Ueoka, Mine Harada;
Small cell lung cancer can express CD34 antigen.
Anticancer Res. 17:3627-3632(1997)

PubMed=10358721; DOI=10.18926/AMO/31626
Akio Matsushita, Masahiro Tabata, Hiroshi Ueoka, Katsuyuki Kiura, Takuo Shibayama, Keisuke Aoe, Hiroyuki Kohara, Mine Harada;
Establishment of a drug sensitivity panel using human lung cancer cell lines.
Acta Med. Okayama 53:67-75(1999)

PubMed=10536175; DOI=10.3892/ijo.15.5.927
Takeshi Fujita, Masaharu Kiyama, Yoshio Tomizawa, Takashi Kohno, Jun Yokota;
Comprehensive analysis of p53 gene mutation characteristics in lung carcinoma with special reference to histological subtypes.
Int. J. Oncol. 15:927-934(1999)

PubMed=11005564; DOI=10.1038/sj.neo.7900094; PMCID=PMC1550293
Takashi Kohno, Takako Sato, Satoshi Takakura, Kimiko Takei, Kaoru Inoue, Michiho Nishioka, Jun Yokota;
Mutation and expression of the DCC gene in human lung cancer.
Neoplasia 2:300-305(2000)

PubMed=12107105; DOI=10.1016/S0002-9440(10)64172-7; PMCID=PMC1850681
Sana Yokoi, Kohichiroh Yasui, Fumiko Saito-Ohara, Katsumi Koshikawa, Toshihiko Iizasa, Takehiko Fujisawa, Takeo Terasaki, Akira Horii, Takashi Takahashi, Setsuo Hirohashi, Johji Inazawa;
A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers.
Am. J. Pathol. 161:207-216(2002)

PubMed=15016488; DOI=10.1016/S0140-6736(04)15693-6
Michael H. Jones, Carl Virtanen, Daisuke Honjoh, Tatsu Miyoshi, Yukitoshi Satoh, Sakae Okumura, Ken Nakagawa, Hitoshi Nomura, Yuichi Ishikawa;
Two prognostically significant subtypes of high-grade lung neuroendocrine tumours independent of small-cell and large-cell neuroendocrine carcinomas identified by gene expression profiles.
Lancet 363:775-781(2004)

PubMed=19472407; DOI=10.1002/humu.21028; PMCID=PMC2900846
Raquel Blanco, Reika Iwakawa, Mo-Ying Tang, Takashi Kohno, Barbara Angulo, Ruben Pio, Luis M. Montuenga, John D. Minna, Jun Yokota, Montse Sanchez-Cespedes;
A gene-alteration profile of human lung cancer cell lines.
Hum. Mutat. 30:1199-1206(2009)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20557307; DOI=10.1111/j.1349-7006.2010.01622.x; PMCID=PMC11158680
Reika Iwakawa, Takashi Kohno, Masatoshi Enari, Tohru Kiyono, Jun Yokota;
Prevalence of human papillomavirus 16/18/33 infection and p53 mutation in lung adenocarcinoma.
Cancer Sci. 101:1891-1896(2010)

PubMed=23716474; DOI=10.1002/gcc.22076; PMCID=PMC3806277
Reika Iwakawa, Masataka Takenaka, Takashi Kohno, Yoko Shimada, Yasushi Totoki, Tatsuhiro Shibata, Koji Tsuta, Ryo Nishikawa, Masayuki Noguchi, Aiko Sato-Otsubo, Seishi Ogawa, Jun Yokota;
Genome-wide identification of genes with amplification and/or fusion in small cell lung cancer.
Genes Chromosomes Cancer 52:802-816(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

PubMed=38639832; DOI=10.1007/s13577-024-01055-0; PMCID=PMC11194210
Fumio Kasai, Makoto Fukushima, Yohei Miyagi, Yukio Nakamura;
Genetic diversity among the present Japanese population: evidence from genotyping of human cell lines established in Japan.
Hum. Cell 37:944-950(2024)

Cross-references
Cell line collections (Providers) JCRB; JCRB0235
RCB; RCB0466
Cell line databases/resources CLO; CLO_0037021
CLO; CLO_0037022
CLO; CLO_0050028
cancercelllines; CVCL_1387
Cell_Model_Passport; SIDM00296
CGH-DB; 100-1
CGH-DB; 9059-4
Cosmic-CLP; 753588
DepMap; ACH-002051
LINCS_LDP; LCL-1871
LINCS_LDP; LCL-1877
Biological sample resources BioSample; SAMN03471661
Chemistry resources ChEMBL-Cells; CHEMBL3308292
ChEMBL-Targets; CHEMBL2366236
GDSC; 753588
PharmacoDB; LU134A_865_2019
PubChem_Cell_line; CVCL_1387
Encyclopedic resources Wikidata; Q54903191
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM17310
GEO; GSM1670063
Polymorphism and mutation databases Cosmic; 713881
Cosmic; 753588
Cosmic; 801604
Cosmic; 809119
Cosmic; 844808
Cosmic; 876158
Cosmic; 918005
Cosmic; 929157
Cosmic; 1212193
Cosmic; 1219094
Cosmic; 1239929
Cosmic; 1571749
Cosmic; 1995493
Cosmic; 2125172
Cosmic; 2668338
IARC_TP53; 1014
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number42