ID Lu-134-A AC CVCL_1387 AS CVCL_2790 SY Lu-134-a; LU-134-A; LU-134A; Lu-134A; Lu134A; LU-134; Lu-134; Lu134; NCC-c-Lu-134-A-H; Lu-134-A-H; LU-134-A-H; Lu-134-AH; LU-134-AH; Lu134-A-H; Lu134-AH; Lu134AH DR CLO; CLO_0037021 DR CLO; CLO_0037022 DR CLO; CLO_0050028 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-3610 DR BioSample; SAMN03471661 DR cancercelllines; CVCL_1387 DR Cell_Model_Passport; SIDM00296 DR CGH-DB; 100-1 DR CGH-DB; 9059-4 DR ChEMBL-Cells; CHEMBL3308292 DR ChEMBL-Targets; CHEMBL2366236 DR Cosmic; 713881 DR Cosmic; 753588 DR Cosmic; 801604 DR Cosmic; 809119 DR Cosmic; 844808 DR Cosmic; 876158 DR Cosmic; 918005 DR Cosmic; 929157 DR Cosmic; 1212193 DR Cosmic; 1219094 DR Cosmic; 1239929 DR Cosmic; 1571749 DR Cosmic; 1995493 DR Cosmic; 2125172 DR Cosmic; 2668338 DR Cosmic-CLP; 753588 DR DepMap; ACH-002051 DR EGA; EGAS00001000978 DR GDSC; 753588 DR GEO; GSM17310 DR GEO; GSM1670063 DR IARC_TP53; 1014 DR JCRB; JCRB0235 DR LINCS_LDP; LCL-1871 DR LINCS_LDP; LCL-1877 DR PharmacoDB; LU134A_865_2019 DR PRIDE; PXD030304 DR PubChem_Cell_line; CVCL_1387 DR RCB; RCB0466 DR Wikidata; Q54903191 RX DOI=10.5795/jjscc.24.451; RX PubMed=1312700; RX PubMed=1847845; RX PubMed=3022030; RX PubMed=6098504; RX PubMed=8263009; RX PubMed=8286010; RX PubMed=9413215; RX PubMed=10358721; RX PubMed=10536175; RX PubMed=11005564; RX PubMed=12107105; RX PubMed=15016488; RX PubMed=19472407; RX PubMed=20164919; RX PubMed=20557307; RX PubMed=23716474; RX PubMed=27397505; RX PubMed=30894373; RX PubMed=35839778; RX PubMed=38639832; CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Population: Japanese. CC Doubling time: 46 hours (PubMed=3022030; PubMed=6098504); 51.9 hours (PubMed=8286010). CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro278Leu (c.833C>T); ClinVar=VCV000232497; Zygosity=Unspecified (PubMed=1312700; PubMed=8263009; PubMed=10536175; PubMed=20557307). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0.6%; Native American=0%; East Asian, North=73.6%; East Asian, South=23.8%; South Asian=1.7%; European, North=0.3%; European, South=0% (PubMed=30894373). CC Derived from site: In situ; Lung; UBERON=UBERON_0002048. ST Source(s): Cosmic-CLP=753588; JCRB=JCRB0235; RCB=RCB0466 ST Amelogenin: X ST CSF1PO: 12 ST D13S317: 9 ST D16S539: 9 ST D5S818: 11 ST D7S820: 11 ST TH01: 9 ST TPOX: 11 ST vWA: 17 DI NCIt; C4917; Lung small cell carcinoma DI ORDO; Orphanet_70573; Small cell lung cancer OX NCBI_TaxID=9606; ! Homo sapiens (Human) OI CVCL_1388 ! Lu-134-B SX Male AG 80Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 42 CH CVCL_6862 ! Lu-130 // RX PubMed=15016488; DOI=10.1016/S0140-6736(04)15693-6; RA Jones, Michael H. RA Virtanen, Carl RA Honjoh, Daisuke RA Miyoshi, Tatsu RA Satoh, Yukitoshi RA Okumura, Sakae RA Nakagawa, Ken RA Nomura, Hitoshi RA Ishikawa, Yuichi RT "Two prognostically significant subtypes of high-grade lung RT neuroendocrine tumours independent of small-cell and large-cell RT neuroendocrine carcinomas identified by gene expression profiles."; RL Lancet 363:775-781(2004). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=8263009; DOI=10.1007/BF01202192; RA Kashii, Tatsuhiko RA Mizushima, Yutaka RA Monno, Satoshi RA Nakagawa, K. RA Kobayashi, M. RT "Gene analysis of K-, H-ras, p53, and retinoblastoma susceptibility RT genes in human lung cancer cell lines by the polymerase chain RT reaction/single-strand conformation polymorphism method."; RL J. Cancer Res. Clin. Oncol. 120:143-148(1994). // RX DOI=10.5795/jjscc.24.451; RA Tsumuraya, Masaru RA Nakajima, Takashi RA Terasaki, Takeo RA Kodama, Tetsuro RA Shimosato, Yukio RA Higuchi, Hisaaki RA Uei, Yoshio RT "Analysis of LDH isoenzyme patterns in cell lines of the small cell RT carcinoma (lung) and retinoblastoma."; RL Nihon Rinsho Saibo Gakkai Zasshi 24:451-456(1985). // RX PubMed=38639832; DOI=10.1007/s13577-024-01055-0; PMCID=PMC11194210; RA Kasai, Fumio RA Fukushima, Makoto RA Miyagi, Yohei RA Nakamura, Yukio RT "Genetic diversity among the present Japanese population: evidence RT from genotyping of human cell lines established in Japan."; RL Hum. Cell 37:944-950(2024). // RX PubMed=20557307; DOI=10.1111/j.1349-7006.2010.01622.x; PMCID=PMC11158680; RA Iwakawa, Reika RA Kohno, Takashi RA Enari, Masatoshi RA Kiyono, Tohru RA Yokota, Jun RT "Prevalence of human papillomavirus 16/18/33 infection and p53 RT mutation in lung adenocarcinoma."; RL Cancer Sci. 101:1891-1896(2010). // RX PubMed=9413215; RA Yamane, Hiromishi RA Kiura, Katsuyuki RA Tabata, Masahiro RA Bessho, Akihiro RA Tsuchida, Tadashi RA Motoda, Kinya RA Hiraki, Akio RA Ueoka, Hiroshi RA Harada, Mine RT "Small cell lung cancer can express CD34 antigen."; RL Anticancer Res. 17:3627-3632(1997). // RX PubMed=3022030; DOI=10.1093/oxfordjournals.jjco.a039144; RA Terasaki, Takeo RA Shimosato, Yukio RA Nakajima, Takashi RA Tsumuraya, Masaru RA Morinaga, Shojiroh RA Hirohashi, Setsuo RA Yamaguchi, Ken RA Kato, Kanefusa RA Ichinose, Hiroshi RA Nagatsu, Toshiharu RT "Changes in cell characteristics due to culture conditions in cell RT lines from human small cell lung cancer."; RL Jpn. J. Clin. Oncol. 16:203-212(1986). // RX PubMed=11005564; DOI=10.1038/sj.neo.7900094; PMCID=PMC1550293; RA Kohno, Takashi RA Sato, Takako RA Takakura, Satoshi RA Takei, Kimiko RA Inoue, Kaoru RA Nishioka, Michiho RA Yokota, Jun RT "Mutation and expression of the DCC gene in human lung cancer."; RL Neoplasia 2:300-305(2000). // RX PubMed=23716474; DOI=10.1002/gcc.22076; PMCID=PMC3806277; RA Iwakawa, Reika RA Takenaka, Masataka RA Kohno, Takashi RA Shimada, Yoko RA Totoki, Yasushi RA Shibata, Tatsuhiro RA Tsuta, Koji RA Nishikawa, Ryo RA Noguchi, Masayuki RA Sato-Otsubo, Aiko RA Ogawa, Seishi RA Yokota, Jun RT "Genome-wide identification of genes with amplification and/or fusion RT in small cell lung cancer."; RL Genes Chromosomes Cancer 52:802-816(2013). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=10358721; DOI=10.18926/AMO/31626; RA Matsushita, Akio RA Tabata, Masahiro RA Ueoka, Hiroshi RA Kiura, Katsuyuki RA Shibayama, Takuo RA Aoe, Keisuke RA Kohara, Hiroyuki RA Harada, Mine RT "Establishment of a drug sensitivity panel using human lung cancer RT cell lines."; RL Acta Med. Okayama 53:67-75(1999). // RX PubMed=12107105; DOI=10.1016/S0002-9440(10)64172-7; PMCID=PMC1850681; RA Yokoi, Sana RA Yasui, Kohichiroh RA Saito-Ohara, Fumiko RA Koshikawa, Katsumi RA Iizasa, Toshihiko RA Fujisawa, Takehiko RA Terasaki, Takeo RA Horii, Akira RA Takahashi, Takashi RA Hirohashi, Setsuo RA Inazawa, Johji RT "A novel target gene, SKP2, within the 5p13 amplicon that is RT frequently detected in small cell lung cancers."; RL Am. J. Pathol. 161:207-216(2002). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=6098504; DOI=10.20772/cancersci1959.75.12_1089; RA Terasaki, Takeo RA Kameya, Toru RA Nakajima, Takashi RA Tsumuraya, Masaru RA Shimosato, Yukio RA Kato, Kanefusa RA Ichinose, Hiroshi RA Nagatsu, Toshiharu RA Hasegawa, Tomoko RT "Interconversion of biological characteristics of small cell lung RT cancer depending on culture conditions."; RL Gann 75:1089-1099(1984). // RX PubMed=1312700; RA Sameshima, Yuichi RA Matsuno, Yoshihiro RA Hirohashi, Setsuo RA Shimosato, Yukio RA Mizoguchi, Hideaki RA Sugimura, Takashi RA Terada, Masaaki RA Yokota, Jun RT "Alterations of the p53 gene are common and critical events for the RT maintenance of malignant phenotypes in small-cell lung carcinoma."; RL Oncogene 7:451-457(1992). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=8286010; RA Kiura, Katsuyuki RA Watarai, Shinobu RA Shibayama, Takuo RA Ohnoshi, Taisuke RA Kimura, Ikuro RA Yasuda, Tatsuji RT "Inhibitory effects of cholera toxin on in vitro growth of human lung RT cancer cell lines."; RL Anticancer Drug Des. 8:417-428(1993). // RX PubMed=19472407; DOI=10.1002/humu.21028; PMCID=PMC2900846; RA Blanco, Raquel RA Iwakawa, Reika RA Tang, Mo-Ying RA Kohno, Takashi RA Angulo, Barbara RA Pio, Ruben RA Montuenga, Luis M. RA Minna, John D. RA Yokota, Jun RA Sanchez-Cespedes, Montse RT "A gene-alteration profile of human lung cancer cell lines."; RL Hum. Mutat. 30:1199-1206(2009). // RX PubMed=1847845; DOI=10.1007/BF00685110; RA Sasaki, Yasutsuna RA Shinkai, Tetsu RA Eguchi, Kenji RA Tamura, Tomohide RA Ohe, Yuichiro RA Ohmori, Tohru RA Saijo, Nagahiro RT "Prediction of the antitumor activity of new platinum analogs based on RT their ex vivo pharmacodynamics as determined by bioassay."; RL Cancer Chemother. Pharmacol. 27:263-270(1991). // RX PubMed=10536175; DOI=10.3892/ijo.15.5.927; RA Fujita, Takeshi RA Kiyama, Masaharu RA Tomizawa, Yoshio RA Kohno, Takashi RA Yokota, Jun RT "Comprehensive analysis of p53 gene mutation characteristics in lung RT carcinoma with special reference to histological subtypes."; RL Int. J. Oncol. 15:927-934(1999). //