ID   Lu-134-A
AC   CVCL_1387
AS   CVCL_2790
SY   Lu-134-a; LU-134-A; LU-134A; Lu-134A; Lu134A; LU-134; Lu-134; Lu134; NCC-c-Lu-134-A-H; Lu-134-A-H; LU-134-A-H; Lu-134-AH; LU-134-AH; Lu134-A-H; Lu134-AH; Lu134AH
DR   CLO; CLO_0037021
DR   CLO; CLO_0037022
DR   CLO; CLO_0050028
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-3610
DR   BioSample; SAMN03471661
DR   cancercelllines; CVCL_1387
DR   Cell_Model_Passport; SIDM00296
DR   CGH-DB; 100-1
DR   CGH-DB; 9059-4
DR   ChEMBL-Cells; CHEMBL3308292
DR   ChEMBL-Targets; CHEMBL2366236
DR   Cosmic; 713881
DR   Cosmic; 753588
DR   Cosmic; 801604
DR   Cosmic; 809119
DR   Cosmic; 844808
DR   Cosmic; 876158
DR   Cosmic; 918005
DR   Cosmic; 929157
DR   Cosmic; 1212193
DR   Cosmic; 1219094
DR   Cosmic; 1239929
DR   Cosmic; 1571749
DR   Cosmic; 1995493
DR   Cosmic; 2125172
DR   Cosmic; 2668338
DR   Cosmic-CLP; 753588
DR   DepMap; ACH-002051
DR   EGA; EGAS00001000978
DR   GDSC; 753588
DR   GEO; GSM17310
DR   GEO; GSM1670063
DR   IARC_TP53; 1014
DR   JCRB; JCRB0235
DR   LINCS_LDP; LCL-1871
DR   LINCS_LDP; LCL-1877
DR   PharmacoDB; LU134A_865_2019
DR   PRIDE; PXD030304
DR   PubChem_Cell_line; CVCL_1387
DR   RCB; RCB0466
DR   Wikidata; Q54903191
RX   DOI=10.5795/jjscc.24.451;
RX   PubMed=1312700;
RX   PubMed=1847845;
RX   PubMed=3022030;
RX   PubMed=6098504;
RX   PubMed=8263009;
RX   PubMed=8286010;
RX   PubMed=9413215;
RX   PubMed=10358721;
RX   PubMed=10536175;
RX   PubMed=11005564;
RX   PubMed=12107105;
RX   PubMed=15016488;
RX   PubMed=19472407;
RX   PubMed=20164919;
RX   PubMed=20557307;
RX   PubMed=23716474;
RX   PubMed=27397505;
RX   PubMed=30894373;
RX   PubMed=35839778;
RX   PubMed=38639832;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Japanese.
CC   Doubling time: 46 hours (PubMed=3022030; PubMed=6098504); 51.9 hours (PubMed=8286010).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro278Leu (c.833C>T); ClinVar=VCV000232497; Zygosity=Unspecified (PubMed=1312700; PubMed=8263009; PubMed=10536175; PubMed=20557307).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=0.6%; Native American=0%; East Asian, North=73.6%; East Asian, South=23.8%; South Asian=1.7%; European, North=0.3%; European, South=0% (PubMed=30894373).
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
ST   Source(s): Cosmic-CLP=753588; JCRB=JCRB0235; RCB=RCB0466
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 9
ST   D16S539: 9
ST   D5S818: 11
ST   D7S820: 11
ST   TH01: 9
ST   TPOX: 11
ST   vWA: 17
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_1388 ! Lu-134-B
SX   Male
AG   80Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 42
//
RX   DOI=10.5795/jjscc.24.451;
RA   Tsumuraya, Masaru
RA   Nakajima, Takashi
RA   Terasaki, Takeo
RA   Kodama, Tetsuro
RA   Shimosato, Yukio
RA   Higuchi, Hisaaki
RA   Uei, Yoshio
RT   "Analysis of LDH isoenzyme patterns in cell lines of the small cell
RT   carcinoma (lung) and retinoblastoma.";
RL   Nihon Rinsho Saibo Gakkai Zasshi 24:451-456(1985).
//
RX   PubMed=1312700;
RA   Sameshima, Yuichi
RA   Matsuno, Yoshihiro
RA   Hirohashi, Setsuo
RA   Shimosato, Yukio
RA   Mizoguchi, Hideaki
RA   Sugimura, Takashi
RA   Terada, Masaaki
RA   Yokota, Jun
RT   "Alterations of the p53 gene are common and critical events for the
RT   maintenance of malignant phenotypes in small-cell lung carcinoma.";
RL   Oncogene 7:451-457(1992).
//
RX   PubMed=1847845; DOI=10.1007/BF00685110;
RA   Sasaki, Yasutsuna
RA   Shinkai, Tetsu
RA   Eguchi, Kenji
RA   Tamura, Tomohide
RA   Ohe, Yuichiro
RA   Ohmori, Tohru
RA   Saijo, Nagahiro
RT   "Prediction of the antitumor activity of new platinum analogs based on
RT   their ex vivo pharmacodynamics as determined by bioassay.";
RL   Cancer Chemother. Pharmacol. 27:263-270(1991).
//
RX   PubMed=3022030; DOI=10.1093/oxfordjournals.jjco.a039144;
RA   Terasaki, Takeo
RA   Shimosato, Yukio
RA   Nakajima, Takashi
RA   Tsumuraya, Masaru
RA   Morinaga, Shojiroh
RA   Hirohashi, Setsuo
RA   Yamaguchi, Ken
RA   Kato, Kanefusa
RA   Ichinose, Hiroshi
RA   Nagatsu, Toshiharu
RT   "Changes in cell characteristics due to culture conditions in cell
RT   lines from human small cell lung cancer.";
RL   Jpn. J. Clin. Oncol. 16:203-212(1986).
//
RX   PubMed=6098504; DOI=10.20772/cancersci1959.75.12_1089;
RA   Terasaki, Takeo
RA   Kameya, Toru
RA   Nakajima, Takashi
RA   Tsumuraya, Masaru
RA   Shimosato, Yukio
RA   Kato, Kanefusa
RA   Ichinose, Hiroshi
RA   Nagatsu, Toshiharu
RA   Hasegawa, Tomoko
RT   "Interconversion of biological characteristics of small cell lung
RT   cancer depending on culture conditions.";
RL   Gann 75:1089-1099(1984).
//
RX   PubMed=8263009; DOI=10.1007/BF01202192;
RA   Kashii, Tatsuhiko
RA   Mizushima, Yutaka
RA   Monno, Satoshi
RA   Nakagawa, K.
RA   Kobayashi, M.
RT   "Gene analysis of K-, H-ras, p53, and retinoblastoma susceptibility
RT   genes in human lung cancer cell lines by the polymerase chain
RT   reaction/single-strand conformation polymorphism method.";
RL   J. Cancer Res. Clin. Oncol. 120:143-148(1994).
//
RX   PubMed=8286010;
RA   Kiura, Katsuyuki
RA   Watarai, Shinobu
RA   Shibayama, Takuo
RA   Ohnoshi, Taisuke
RA   Kimura, Ikuro
RA   Yasuda, Tatsuji
RT   "Inhibitory effects of cholera toxin on in vitro growth of human lung
RT   cancer cell lines.";
RL   Anticancer Drug Des. 8:417-428(1993).
//
RX   PubMed=9413215;
RA   Yamane, Hiromishi
RA   Kiura, Katsuyuki
RA   Tabata, Masahiro
RA   Bessho, Akihiro
RA   Tsuchida, Tadashi
RA   Motoda, Kinya
RA   Hiraki, Akio
RA   Ueoka, Hiroshi
RA   Harada, Mine
RT   "Small cell lung cancer can express CD34 antigen.";
RL   Anticancer Res. 17:3627-3632(1997).
//
RX   PubMed=10358721; DOI=10.18926/AMO/31626;
RA   Matsushita, Akio
RA   Tabata, Masahiro
RA   Ueoka, Hiroshi
RA   Kiura, Katsuyuki
RA   Shibayama, Takuo
RA   Aoe, Keisuke
RA   Kohara, Hiroyuki
RA   Harada, Mine
RT   "Establishment of a drug sensitivity panel using human lung cancer
RT   cell lines.";
RL   Acta Med. Okayama 53:67-75(1999).
//
RX   PubMed=10536175; DOI=10.3892/ijo.15.5.927;
RA   Fujita, Takeshi
RA   Kiyama, Masaharu
RA   Tomizawa, Yoshio
RA   Kohno, Takashi
RA   Yokota, Jun
RT   "Comprehensive analysis of p53 gene mutation characteristics in lung
RT   carcinoma with special reference to histological subtypes.";
RL   Int. J. Oncol. 15:927-934(1999).
//
RX   PubMed=11005564; DOI=10.1038/sj.neo.7900094; PMCID=PMC1550293;
RA   Kohno, Takashi
RA   Sato, Takako
RA   Takakura, Satoshi
RA   Takei, Kimiko
RA   Inoue, Kaoru
RA   Nishioka, Michiho
RA   Yokota, Jun
RT   "Mutation and expression of the DCC gene in human lung cancer.";
RL   Neoplasia 2:300-305(2000).
//
RX   PubMed=12107105; DOI=10.1016/S0002-9440(10)64172-7; PMCID=PMC1850681;
RA   Yokoi, Sana
RA   Yasui, Kohichiroh
RA   Saito-Ohara, Fumiko
RA   Koshikawa, Katsumi
RA   Iizasa, Toshihiko
RA   Fujisawa, Takehiko
RA   Terasaki, Takeo
RA   Horii, Akira
RA   Takahashi, Takashi
RA   Hirohashi, Setsuo
RA   Inazawa, Johji
RT   "A novel target gene, SKP2, within the 5p13 amplicon that is
RT   frequently detected in small cell lung cancers.";
RL   Am. J. Pathol. 161:207-216(2002).
//
RX   PubMed=15016488; DOI=10.1016/S0140-6736(04)15693-6;
RA   Jones, Michael H.
RA   Virtanen, Carl
RA   Honjoh, Daisuke
RA   Miyoshi, Tatsu
RA   Satoh, Yukitoshi
RA   Okumura, Sakae
RA   Nakagawa, Ken
RA   Nomura, Hitoshi
RA   Ishikawa, Yuichi
RT   "Two prognostically significant subtypes of high-grade lung
RT   neuroendocrine tumours independent of small-cell and large-cell
RT   neuroendocrine carcinomas identified by gene expression profiles.";
RL   Lancet 363:775-781(2004).
//
RX   PubMed=19472407; DOI=10.1002/humu.21028; PMCID=PMC2900846;
RA   Blanco, Raquel
RA   Iwakawa, Reika
RA   Tang, Mo-Ying
RA   Kohno, Takashi
RA   Angulo, Barbara
RA   Pio, Ruben
RA   Montuenga, Luis M.
RA   Minna, John D.
RA   Yokota, Jun
RA   Sanchez-Cespedes, Montse
RT   "A gene-alteration profile of human lung cancer cell lines.";
RL   Hum. Mutat. 30:1199-1206(2009).
//
RX   PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113;
RA   Bignell, Graham Robert
RA   Greenman, Christopher D.
RA   Davies, Helen R.
RA   Butler, Adam P.
RA   Edkins, Sarah
RA   Andrews, Jenny M.
RA   Buck, Gemma
RA   Chen, Lina
RA   Beare, David
RA   Latimer, Calli
RA   Widaa, Sara
RA   Hinton, Jonathan
RA   Fahey, Ciara
RA   Fu, Bei-Yuan
RA   Swamy, Sajani
RA   Dalgliesh, Gillian L.
RA   Teh, Bin Tean
RA   Deloukas, Panos
RA   Yang, Feng-Tang
RA   Campbell, Peter J.
RA   Futreal, P. Andrew
RA   Stratton, Michael Rudolf
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=20557307; DOI=10.1111/j.1349-7006.2010.01622.x; PMCID=PMC11158680;
RA   Iwakawa, Reika
RA   Kohno, Takashi
RA   Enari, Masatoshi
RA   Kiyono, Tohru
RA   Yokota, Jun
RT   "Prevalence of human papillomavirus 16/18/33 infection and p53
RT   mutation in lung adenocarcinoma.";
RL   Cancer Sci. 101:1891-1896(2010).
//
RX   PubMed=23716474; DOI=10.1002/gcc.22076; PMCID=PMC3806277;
RA   Iwakawa, Reika
RA   Takenaka, Masataka
RA   Kohno, Takashi
RA   Shimada, Yoko
RA   Totoki, Yasushi
RA   Shibata, Tatsuhiro
RA   Tsuta, Koji
RA   Nishikawa, Ryo
RA   Noguchi, Masayuki
RA   Sato-Otsubo, Aiko
RA   Ogawa, Seishi
RA   Yokota, Jun
RT   "Genome-wide identification of genes with amplification and/or fusion
RT   in small cell lung cancer.";
RL   Genes Chromosomes Cancer 52:802-816(2013).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   PubMed=38639832; DOI=10.1007/s13577-024-01055-0; PMCID=PMC11194210;
RA   Kasai, Fumio
RA   Fukushima, Makoto
RA   Miyagi, Yohei
RA   Nakamura, Yukio
RT   "Genetic diversity among the present Japanese population: evidence
RT   from genotyping of human cell lines established in Japan.";
RL   Hum. Cell 37:944-950(2024).
//