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Cellosaurus Lu-130 (CVCL_6862)

[Text version]
Cell line name Lu-130
Synonyms NCC-c-Lu-130; LU-130; Lu130
Accession CVCL_6862
Resource Identification Initiative To cite this cell line use: Lu-130 (RRID:CVCL_6862)
Comments Problematic cell line: Contaminated. Shown to be a Lu-134-A (or Lu-134-B) derivative (PubMed=16643607; PubMed=20143388). Originally thought to originate from a 61 year old male patient with small cell lung carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00232.
Population: Japanese.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1387 (Lu-134-A)
Sex of cell Male
Age at sampling 80Y
Category Cancer cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Info; RCB; -; https://cell.brc.riken.jp/ja/quality/str/origin/confirm_report/confirm_table4
Publications

PubMed=3022030; DOI=10.1093/oxfordjournals.jjco.a039144
Takeo Terasaki, Yukio Shimosato, Takashi Nakajima, Masaru Tsumuraya, Shojiroh Morinaga, Setsuo Hirohashi, Ken Yamaguchi, Kanefusa Kato, Hiroshi Ichinose, Toshiharu Nagatsu;
Changes in cell characteristics due to culture conditions in cell lines from human small cell lung cancer.
Jpn. J. Clin. Oncol. 16:203-212(1986)

PubMed=1312700
Yuichi Sameshima, Yoshihiro Matsuno, Setsuo Hirohashi, Yukio Shimosato, Hideaki Mizoguchi, Takashi Sugimura, Masaaki Terada, Jun Yokota;
Alterations of the p53 gene are common and critical events for the maintenance of malignant phenotypes in small-cell lung carcinoma.
Oncogene 7:451-457(1992)

PubMed=10536175; DOI=10.3892/ijo.15.5.927
Takeshi Fujita, Masaharu Kiyama, Yoshio Tomizawa, Takashi Kohno, Jun Yokota;
Comprehensive analysis of p53 gene mutation characteristics in lung carcinoma with special reference to histological subtypes.
Int. J. Oncol. 15:927-934(1999)

PubMed=12107105; DOI=10.1016/S0002-9440(10)64172-7; PMCID=PMC1850681
Sana Yokoi, Kohichiroh Yasui, Fumiko Saito-Ohara, Katsumi Koshikawa, Toshihiko Iizasa, Takehiko Fujisawa, Takeo Terasaki, Akira Horii, Takashi Takahashi, Setsuo Hirohashi, Johji Inazawa;
A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers.
Am. J. Pathol. 161:207-216(2002)

PubMed=15016488; DOI=10.1016/S0140-6736(04)15693-6
Michael H. Jones, Carl Virtanen, Daisuke Honjoh, Tatsu Miyoshi, Yukitoshi Satoh, Sakae Okumura, Ken Nakagawa, Hitoshi Nomura, Yuichi Ishikawa;
Two prognostically significant subtypes of high-grade lung neuroendocrine tumours independent of small-cell and large-cell neuroendocrine carcinomas identified by gene expression profiles.
Lancet 363:775-781(2004)

PubMed=16643607; DOI=10.1111/j.1749-0774.2005.00007.x
Kaori Yoshino, Emi Iimura, Kaoru Saijo, Satsuki Iwase, Kiyoko Fukami, Tadao Ohno, Yuichi Obata, Yukio Nakamura;
Essential role for gene profiling analysis in the authentication of human cell lines.
Hum. Cell 19:43-48(2006)

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Cell line collections (Providers) RCB; RCB0465 - Discontinued
Cell line databases/resources cancercelllines; CVCL_6862
CGH-DB; 89-1
CGH-DB; 9058-4
Biological sample resources BioSample; SAMN03151826
Encyclopedic resources Wikidata; Q54903190
Experimental variables resources EFO; EFO_0003142
Gene expression databases GEO; GSM17309
Polymorphism and mutation databases Cosmic; 809118
Cosmic; 844807
Cosmic; 918004
Cosmic; 1212192
Cosmic; 1571748
Cosmic; 2668337
IARC_TP53; 1013
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number28