• Mutation; HGNC; HGNC:11272; SPTA1; Simple; p.Ser1163Ala (c.3487T>G); ClinVar=VCV000258929; Zygosity=Homozygous (from parent cell line).
  
• Mutation; HGNC; HGNC:11830; TK1; Simple; p.Ala78Argfs*27 (c.231insC); Zygosity=Heterozygous (PubMed=7859358).
  
• Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (PubMed=7744731; PubMed=11221843).
  

PubMed=214074; DOI=10.1016/0006-291X(78)90185-7
Thomas R. Skopek, Howard L. Liber, Bruce W. Penman, William G. Thilly;
Isolation of a human lymphoblastoid line heterozygous at the thymidine kinase locus: possibility for a rapid human cell mutation assay.
Biochem. Biophys. Res. Commun. 84:411-416(1978)

Patent=US4302535
Thomas R. Skopek, Howard L. Liber, Bruce W. Penman, William G. Thilly, Henry Hoppe 4th;
Assay for mutagenesis in heterozygous diploid human lymphoblasts.
Patent number US4302535, 24-Nov-1981

PubMed=3012798; DOI=10.1007/BF01570784
David William Yandell, Thaddeus Peter Dryja, John Bertram Little;
Somatic mutations at a heterozygous autosomal locus in human cells occur more frequently by allele loss than by intragenic structural alterations.
Somat. Cell Mol. Genet. 12:255-263(1986)

PubMed=3745200; DOI=10.1016/S0021-9258(18)67110-8
Victor S. Goldmacher, Robert A. Cuzick Jr., William G. Thilly;
Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation by methylnitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine.
J. Biol. Chem. 261:12462-12471(1986)

PubMed=8316623; DOI=10.2307/3578190
Helen Harrington Evans, Marlene Ricanati, Min-Fen Horng, Qiao-Yun Jiang, Jaroslav Mencl, Peggy Louise Olive;
DNA double-strand break rejoining deficiency in TK6 and other human B-lymphoblast cell lines.
Radiat. Res. 134:307-315(1993)

PubMed=7565900; DOI=10.1016/0165-7992(95)00027-5
Li-Shi Zhang, Masamitsu Honma, Makoto Hayashi, Takayoshi Suzuki, Atsuko Matsuoka, Toshio Sofuni;
A comparative study of TK6 human lymphoblastoid and L5178Y mouse lymphoma cell lines in the in vitro micronucleus test.
Mutat. Res. 347:105-115(1995)

PubMed=7744731; DOI=10.1074/jbc.270.19.11033
John Bertram Little, Hatsumi Nagasawa, Peter C. Keng, Yong-Jia Yu, Chuan-Yuan Li;
Absence of radiation-induced G1 arrest in two closely related human lymphoblast cell lines that differ in p53 status.
J. Biol. Chem. 270:11033-11036(1995)

PubMed=7859358; DOI=10.1093/carcin/16.2.267
Cynthia R. Giver, Stephen L. Nelson Jr., Mirabelle Y. Cha, Punnajit Pongsaensook, Andrew J. Grosovsky;
Mutational spectrum of X-ray induced TK- human cell mutants.
Carcinogenesis 16:267-275(1995)

PubMed=9258685; DOI=10.1093/genetics/146.4.1429; PMCID=PMC1208086
Cynthia R. Giver, Andrew J. Grosovsky;
Single and coincident intragenic mutations attributable to gene conversion in a human cell line.
Genetics 146:1429-1439(1997)

PubMed=10397247
Yao-Yu Eric Chuang, Qi Chen, Joseph P. Brown, John Michael Sedivy, Howard L. Liber;
Radiation-induced mutations at the autosomal thymidine kinase locus are not elevated in p53-null cells.
Cancer Res. 59:3073-3076(1999)

PubMed=11221843
Claudia Wiese, Stacey S. Gauny, Wei-Chung Liu, Corinne L. Cherbonnel-Lasserre, Amy Kronenberg;
Different mechanisms of radiation-induced loss of heterozygosity in two human lymphoid cell lines from a single donor.
Cancer Res. 61:1129-1137(2001)

PubMed=15033590; DOI=10.1289/ehp.6709; PMCID=PMC1241894
Ronald K. Newton, Marilyn J. Aardema, Jiri Aubrecht;
The utility of DNA microarrays for characterizing genotoxicity.
Environ. Health Perspect. 112:420-422(2004)

PubMed=18805990; DOI=10.1101/gad.1688508; PMCID=PMC2559901
Rebecca C. Fry, J. Peter Svensson, Chandni Valiathan, Emma Wang, Brad J. Hogan, Sanchita Bhattacharya, James M. Bugni, Charles A. Whittaker, Leona D. Samson;
Genomic predictors of interindividual differences in response to DNA damaging agents.
Genes Dev. 22:2621-2626(2008)

PubMed=22042714; DOI=10.1093/mutage/ger074
Kiyohiro Hashimoto, Yumi Nakajima, Rieko Uematsu, Fumio Chatani;
Difference in susceptibility to morphological changes in the nucleus to aneugens between p53-competent and p53-abrogated lymphoblastoid cell lines (TK6 and NH32 cells) in the in vitro micronucleus assay.
Mutagenesis 27:287-293(2012)

PubMed=22525470; DOI=10.18926/AMO/48262
Hiroaki Oka, Mamoru Ouchida, Takuya Kondo, Fumio Morita, Kenji Shimizu;
Different responses to 5-fluoraouracil in mutagenicity and gene expression between two human lymphoblastoid cell lines with or without TP53 mutation.
Acta Med. Okayama 66:119-129(2012)

PubMed=26774668; DOI=10.1016/j.mrgentox.2015.11.006
Javier Revollo, Dayton M. Petibone, Page McKinzie, Bridgett Knox, Suzanne M. Morris, Bai-Tang Ning, Vasily N. Dobrovolsky;
Whole genome and normalized mRNA sequencing reveal genetic status of TK6, WTK1, and NH32 human B-lymphoblastoid cell lines.
Mutat. Res. Genet. Toxicol. Environ. Mutagen. 795:60-69(2016)

PubMed=27692294; DOI=10.1016/j.mrgentox.2016.08.001
Elisabeth Lorge, Martha May Moore, Julie Clements, Michael Rickard O'Donovan, Mick D. Fellows, Masamitsu Honma, Arihiro Kohara, Sheila Margaret Galloway, Michael J. Armstrong, Veronique Thybaud, Bala Bhaskar Gollapudi ...Show all 13 authors... , Marilyn J. Aardema, Jennifer Young Tanir; Show fewer authors
Standardized cell sources and recommendations for good cell culture practices in genotoxicity testing.
Mutat. Res. Genet. Toxicol. Environ. Mutagen. 809:1-15(2016)