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Cellosaurus TSCE5 (CVCL_WN50)

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Cell line name TSCE5
Accession CVCL_WN50
Resource Identification Initiative To cite this cell line use: TSCE5 (RRID:CVCL_WN50)
Comments Group: Space-flown cell line (cellonaut).
Population: Caucasian.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Transformant: ChEBI; CHEBI_132982; Acridine half-mustard dihydrochloride (6-chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride; Acridine mutagen ICR 191).
Anecdotal: Have been flown in space on the ISS in 2008-2009 to study the biological effects of space radiations, microgravity and the space environment on the expression of TP53-regulated genes (PubMed=20673130; PubMed=21161544).
Derived from site: In situ; Spleen; UBERON=UBERON_0002106.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Mutation; HGNC; HGNC:11272; SPTA1; Simple; p.Ser1163Ala (c.3487T>G); ClinVar=VCV000258929; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11830; TK1; Simple; p.Ala78Argfs*27 (c.231insC); Zygosity=Heterozygous (from parent cell line).
Disease Hereditary spherocytosis (NCIt: C97074)
Hereditary spherocytosis (ORDO: Orphanet_822)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0561 (TK6)
Children:
CVCL_WN51 (TSCER2)
Sex of cell Male
Age at sampling 5Y
Category Transformed cell line
Publications

PubMed=14673874; DOI=10.1002/em.10201
Masamitsu Honma, Masako Izumi, Mayumi Sakuraba, Satoshi Tadokoro, Hiroko Sakamoto, Wen-Sheng Wang, Fumio Yatagai, Makoto Hayashi;
Deletion, rearrangement, and gene conversion; genetic consequences of chromosomal double-strand breaks in human cells.
Environ. Mol. Mutagen. 42:288-298(2003)

PubMed=20673130; DOI=10.3109/09553001003789596
Akihisa Takahashi, Hiromi Suzuki, Katsunori Omori, Masaya Seki, Toko Hashizume, Toru Shimazu, Noriaki Ishioka, Takeo Ohnishi;
The expression of p53-regulated genes in human cultured lymphoblastoid TSCE5 and WTK1 cell lines during spaceflight.
Int. J. Radiat. Biol. 86:669-681(2010)

PubMed=21161544; DOI=10.1007/s00411-010-0348-3
Fumio Yatagai, Masamitsu Honma, Akihisa Takahashi, Katsunori Omori, Hiromi Suzuki, Toru Shimazu, Masaya Seki, Toko Hashizume, Akiko Ukai, Kaoru Sugasawa, Tomoko Abe ...Show all 16 authors... , Naoshi Dohmae, Shuichi Enomoto, Takeo Ohnishi, Alasdair Gordon, Noriaki Ishioka; Show fewer authors
Frozen human cells can record radiation damage accumulated during space flight: mutation induction and radioadaptation.
Radiat. Environ. Biophys. 50:125-134(2011)

Cross-references
Encyclopedic resources Wikidata; Q98133631
Entry history
Entry creation24-May-2019
Last entry update10-Apr-2025
Version number9