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Cellosaurus TSCE5 (CVCL_WN50)

[Text version]
Cell line name TSCE5
Accession CVCL_WN50
Resource Identification Initiative To cite this cell line use: TSCE5 (RRID:CVCL_WN50)
Comments Group: Space-flown cell line (cellonaut).
Population: Caucasian.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Transformant: ChEBI; CHEBI:132982; Acridine half-mustard dihydrochloride (6-chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride; Acridine mutagen ICR 191).
Anecdotal: Have been flown in space on the ISS in 2008-2009 to study the biological effects of space radiations, microgravity and the space environment on the expression of TP53-regulated genes (PubMed=20673130; PubMed=21161544).
Derived from site: In situ; Spleen; UBERON=UBERON_0002106.
Sequence variations
  • Mutation; HGNC; 11272; SPTA1; Simple; p.Ser1163Ala (c.3487T>G); ClinVar=VCV000258929; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11830; TK1; Simple; p.Ala78Argfs*27 (c.231insC); Zygosity=Heterozygous (from parent cell line).
Disease Hereditary spherocytosis (NCIt: C97074)
Hereditary spherocytosis (ORDO: Orphanet_822)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0561 (TK6)
Sex of cell Male
Age at sampling 5Y
Category Transformed cell line

PubMed=14673874; DOI=10.1002/em.10201
Honma M., Izumi M., Sakuraba M., Tadokoro S., Sakamoto H., Wang W., Yatagai F., Hayashi M.
Deletion, rearrangement, and gene conversion; genetic consequences of chromosomal double-strand breaks in human cells.
Environ. Mol. Mutagen. 42:288-298(2003)

PubMed=20673130; DOI=10.3109/09553001003789596
Takahashi A., Suzuki H., Omori K., Seki M., Hashizume T., Shimazu T., Ishioka N., Ohnishi T.
The expression of p53-regulated genes in human cultured lymphoblastoid TSCE5 and WTK1 cell lines during spaceflight.
Int. J. Radiat. Biol. 86:669-681(2010)

PubMed=21161544; DOI=10.1007/s00411-010-0348-3
Yatagai F., Honma M., Takahashi A., Omori K., Suzuki H., Shimazu T., Seki M., Hashizume T., Ukai A., Sugasawa K., Abe T., Dohmae N., Enomoto S., Ohnishi T., Gordon A., Ishioka N.
Frozen human cells can record radiation damage accumulated during space flight: mutation induction and radioadaptation.
Radiat. Environ. Biophys. 50:125-134(2011)

Encyclopedic resources Wikidata; Q98133631
Entry history
Entry creation24-May-2019
Last entry update29-Jun-2023
Version number7