ID   TSCE5
AC   CVCL_WN50
DR   Wikidata; Q98133631
RX   PubMed=14673874;
RX   PubMed=20673130;
RX   PubMed=21161544;
CC   Group: Space-flown cell line (cellonaut).
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:11272; SPTA1; Simple; p.Ser1163Ala (c.3487T>G); ClinVar=VCV000258929; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11830; TK1; Simple; p.Ala78Argfs*27 (c.231insC); Zygosity=Heterozygous (from parent cell line).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Transformant: ChEBI; CHEBI_132982; Acridine half-mustard dihydrochloride (6-chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride; Acridine mutagen ICR 191).
CC   Anecdotal: Have been flown in space on the ISS in 2008-2009 to study the biological effects of space radiations, microgravity and the space environment on the expression of TP53-regulated genes (PubMed=20673130; PubMed=21161544).
CC   Derived from site: In situ; Spleen; UBERON=UBERON_0002106.
CC   Cell type: B-cell; CL=CL_0000236.
DI   NCIt; C97074; Hereditary spherocytosis
DI   ORDO; Orphanet_822; Hereditary spherocytosis
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0561 ! TK6
SX   Male
AG   5Y
CA   Transformed cell line
DT   Created: 24-05-19; Last updated: 10-04-25; Version: 9
CH   CVCL_WN51 ! TSCER2
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RX   PubMed=14673874; DOI=10.1002/em.10201;
RA   Honma, Masamitsu
RA   Izumi, Masako
RA   Sakuraba, Mayumi
RA   Tadokoro, Satoshi
RA   Sakamoto, Hiroko
RA   Wang, Wen-Sheng
RA   Yatagai, Fumio
RA   Hayashi, Makoto
RT   "Deletion, rearrangement, and gene conversion; genetic consequences of
RT   chromosomal double-strand breaks in human cells.";
RL   Environ. Mol. Mutagen. 42:288-298(2003).
//
RX   PubMed=20673130; DOI=10.3109/09553001003789596;
RA   Takahashi, Akihisa
RA   Suzuki, Hiromi
RA   Omori, Katsunori
RA   Seki, Masaya
RA   Hashizume, Toko
RA   Shimazu, Toru
RA   Ishioka, Noriaki
RA   Ohnishi, Takeo
RT   "The expression of p53-regulated genes in human cultured
RT   lymphoblastoid TSCE5 and WTK1 cell lines during spaceflight.";
RL   Int. J. Radiat. Biol. 86:669-681(2010).
//
RX   PubMed=21161544; DOI=10.1007/s00411-010-0348-3;
RA   Yatagai, Fumio
RA   Honma, Masamitsu
RA   Takahashi, Akihisa
RA   Omori, Katsunori
RA   Suzuki, Hiromi
RA   Shimazu, Toru
RA   Seki, Masaya
RA   Hashizume, Toko
RA   Ukai, Akiko
RA   Sugasawa, Kaoru
RA   Abe, Tomoko
RA   Dohmae, Naoshi
RA   Enomoto, Shuichi
RA   Ohnishi, Takeo
RA   Gordon, Alasdair
RA   Ishioka, Noriaki
RT   "Frozen human cells can record radiation damage accumulated during
RT   space flight: mutation induction and radioadaptation.";
RL   Radiat. Environ. Biophys. 50:125-134(2011).
//