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Cellosaurus AsPC-1 (CVCL_0152)

[Text version]
Cell line name AsPC-1
Synonyms AsPc-1; Aspc-1; ASPC-1; As-PC1; ASPC1; AsPC1; Aspc1; AsPc1
Accession CVCL_0152
Resource Identification Initiative To cite this cell line use: AsPC-1 (RRID:CVCL_0152)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: KuDOS 95 cell line panel.
Part of: MD Anderson Cell Lines Project.
Part of: NCI RAS program mutant KRAS cell line panel.
Population: Caucasian.
Doubling time: ~38-40 hours (PubMed=7182348); 46 hours (PubMed=25984343).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Metabolomics.
Omics: Phenotyping; CRISPR screening.
Omics: Phenotyping; Drug screening.
Omics: Phenotyping; shRNA library screening.
Omics: Proteomics.
Omics: Proteomics; 2DE-MS.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; miRNA profiling; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Transcriptomics; Serial analysis of gene expression (SAGE).
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Caution: TP53 mutation indicated incorrectly as being at c.818G>A in PubMed=1630814.
Misspelling: ASPC; GEO=GSM383935.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
HLA typing Source: PubMed=26589293
Class I
HLA-AA*01:01,26:01
HLA-BB*15:01,15:01
HLA-CC*03:04,03:04

Source: CLS=300158
Class I
HLA-AA*01:01:01,02:01:01
HLA-BB*15:01:01
HLA-CC*03:03:01,03:04:01
Class II
HLA-DPDPB1*04:01:01G,10:01:01G
HLA-DQDQA1*01:02:01,03:01:01
DQB1*03:02:01,06:04:01
HLA-DRDRB1*04:01:01,13:02:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.97
Native American0
East Asian, North3.23
East Asian, South0
South Asian0
European, North58.23
European, South37.57
Disease Pancreatic ductal adenocarcinoma (NCIt: C9120)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_C3NE (AsPC-1 SPINK1 #10)CVCL_J243 (AsPC-1/CMV-Luc)CVCL_XX79 (AsPC1-R)
CVCL_E6XM (AsPC1/GFP)CVCL_E6XP (AsPC1/Luciferase-2A-GFP)CVCL_E6XN (AsPC1/RFP)
CVCL_E1J8 (HyCyte AsPC-1 KO-hLINC00511)CVCL_E3GS (HyCyte AsPC-1-Luc)CVCL_7165 (MPanc-96)
Sex of cell Female
Age at sampling 62Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-1682; CCRID; CLS=300158; Cosmic-CLP=910702; ECACC=96020930; IZSLER=BS TCL 171; KCLB=21682; PubMed=25877200; Technion Genomics Center

Markers:
AmelogeninX
CSF1PO10,13 (ATCC=CRL-1682; CCRID; CLS=300158; Cosmic-CLP=910702; IZSLER=BS TCL 171; KCLB=21682; PubMed=25877200; Technion Genomics Center)
11,13 (ECACC=96020930)
D1S165612,18.3
D2S44111,14
D2S133822,23
D3S135816
D5S81812
D6S104311,20
D7S82012,13
D8S117913,15
D10S124813,14
D12S39119
D13S3179,12 (ATCC=CRL-1682; CCRID; Cosmic-CLP=910702; ECACC=96020930; IZSLER=BS TCL 171; KCLB=21682; PubMed=25877200; Technion Genomics Center)
12 (CLS=300158)
D16S53911
D18S5118
D19S43314
D21S1128,30
D22S104515
FGA24
Penta D9,12
Penta E5,12
TH017,9.3
TPOX8,10
vWA17

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Info; Pawefish; -; https://www.cellosaurus.org/pawefish/PancCellLineDescriptions/AsPC1.html
Info; StRAP; -; https://strap.nci.nih.gov/celline_detail.php?sample_id=66
Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/pancreatic-xenograft-models/aspc-1-xenograft-model/
Publications

PubMed=7182348; DOI=10.1007/BF02796382
W.H. Chen, Julius Stanislaw Horoszewicz, Susan S. Leong, Takashi Shimano, Remedios B. Penetrante, W.H. Sanders, Richard Berjian, Harold Orth Douglass Jr., Edward W. Martin, Tsann Ming Chu;
Human pancreatic adenocarcinoma: in vitro and in vivo morphology of a new tumor line established from ascites.
In Vitro 18:24-34(1982)

PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720
Michael Jules Mattes, Carlos Cordon-Cardo, John L. Lewis Jr., Lloyd John Old, Kenneth Oliver Lloyd;
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

PubMed=4023565
Mong H. Tan, Tsann Ming Chu;
Characterization of the tumorigenic and metastatic properties of a human pancreatic tumor cell line (AsPC-1) implanted orthotopically into nude mice.
Tumor Biol. 6:89-98(1985)

PubMed=1764370; DOI=10.1038/bjc.1991.467; PMCID=PMC1977874
Claire M. Barton, Susan Louise Staddon, Christine M. Hughes, Peter A. Hall, Catriona O'Sullivan, Gunter Kloppel, Belinda Theis, Ronald Christopher Gordon Russell, John Neoptolemos, Robin Charles Noel Williamson, David Philip Lane, Nicholas Robert Lemoine;
Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer.
Br. J. Cancer 64:1076-1082(1991)

PubMed=1630814
Bruce Anthony Ruggeri, Shi-Yu Zhang, Jorge Caamano, Marion DiRado, Stuart Dale Flynn, Andres J.P. Klein-Szanto;
Human pancreatic carcinomas and cell lines reveal frequent and multiple alterations in the p53 and Rb-1 tumor-suppressor genes.
Oncogene 7:1503-1511(1992)

PubMed=7972006; DOI=10.1073/pnas.91.23.11045; PMCID=PMC45163
Aikou Okamoto, Douglas J. Demetrick, Elisa A. Spillare, Koichi Hagiwara, S. Perwez Hussain, William P. Bennett, Kathleen Forrester, Brenda Isen Gerwin, Manuel Serrano, David H. Beach, Curtis Craig Harris;
Mutations and altered expression of p16INK4 in human cancer.
Proc. Natl. Acad. Sci. U.S.A. 91:11045-11049(1994)

PubMed=8026879; DOI=10.1002/ijc.2910580207
Georgina Berrozpe, James Schaeffer, Miguel Angel Peinado, Francisco X. Real, Manuel Perucho;
Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancer.
Int. J. Cancer 58:185-191(1994)

PubMed=8194712; DOI=10.1016/0016-5085(94)90422-7
Babette Simon, Rolf Weinel, Martin Hohne, Jutta Watz, Jorg Schmidt, Gunther Kortner, Rudolf Arnold;
Frequent alterations of the tumor suppressor genes p53 and DCC in human pancreatic carcinoma.
Gastroenterology 106:1645-1651(1994)

PubMed=8286197; DOI=10.1038/bjc.1994.24; PMCID=PMC1968784
Johannes-Matthias Lohr, Birgit Trautmann, Martin Gottler, Shirley Peters, Ira Zauner, Bernard Maillet, Gunter Kloppel;
Human ductal adenocarcinomas of the pancreas express extracellular matrix proteins.
Br. J. Cancer 69:144-151(1994)

PubMed=21607521; DOI=10.3892/or.1.6.1223
Haruo Iguchi, Ryoji Morita, Daisuke Yasuda, Ryoichi Takayanagi, Yurika Ikeda, Yutaka Takada, Takao Shimazoe, Hajime Nawata, Akira Kono;
Alterations of the p53 tumor-suppressor gene and ki-ras oncogene in human pancreatic cancer-derived cell-lines with different metastatic potential.
Oncol. Rep. 1:1223-1227(1994)

PubMed=9331070
David H.-F. Teng, William L. Perry 3rd, James K. Hogan, Michelle L. Baumgard, Russell Bell, Simin Berry, Thaylon Davis, David Frank, Cheryl Frye, Thomas Hattier, Rong Hu ...Show all 28 authors... , Srikanth Jammulapati, Teresa Janecki, Amber Leavitt, Jeffrey T. Mitchell, Ralph Pero, David Sexton, Marianne Schroeder, Pi-Hsia Su, Bradley Swedlund, John M. Kyriakis, Joseph Avruch, Paul Bartel, Alexander K.C. Wong, Arnold Oliphant, Alun Thomas, Mark Henry Skolnick, Sean V. Tavtigian; Show fewer authors
Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor.
Cancer Res. 57:4177-4182(1997)

PubMed=9665481; DOI=10.1016/S0002-9440(10)65561-7; PMCID=PMC1852940
Rosanna Paciucci, Maya R. Vila, Teresa Adell, Victor M. Diaz, Montserrat Tora, Toshikazu Nakamura, Francisco X. Real;
Activation of the urokinase plasminogen activator/urokinase plasminogen activator receptor system and redistribution of E-cadherin are associated with hepatocyte growth factor-induced motility of pancreas tumor cells overexpressing Met.
Am. J. Pathol. 153:201-212(1998)

PubMed=10027410; DOI=10.1016/S0002-9440(10)65298-4; PMCID=PMC1850008
B. Michael Ghadimi, Evelin Schrock, Robert L. Walker, Danny Wangsa, Annukka Jauho, Paul S. Meltzer, Thomas Ried;
Specific chromosomal aberrations and amplification of the AIB1 nuclear receptor coactivator gene in pancreatic carcinomas.
Am. J. Pathol. 154:525-536(1999)

PubMed=10408907; DOI=10.1016/S0304-3835(98)00380-2
Detlef K. Bartsch, Peter Barth, Daniel Bastian, Annette Ramaswamy, Berthold Gerdes, Brunhilde Chaloupka, Yvonne Deiss, Babette Simon, Andreas Schudy;
Higher frequency of DPC4/Smad4 alterations in pancreatic cancer cell lines than in primary pancreatic adenocarcinomas.
Cancer Lett. 139:43-49(1999)

PubMed=11115575; DOI=10.3892/or.8.1.89
Chun-Lan Sun, Takashi Yamato, Toru Furukawa, Yasuyuki Ohnishi, Hiroshi Kijima, Akira Horii;
Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines.
Oncol. Rep. 8:89-92(2001)

PubMed=11169959; DOI=10.1002/1097-0215(200002)9999:9999<::AID-IJC1049>3.0.CO;2-C
Vorapan Sirivatanauksorn, Yongyut Sirivatanauksorn, Patricia A. Gorman, Jeffrey M. Davidson, Denise Sheer, Patrick S. Moore, Aldo Scarpa, Paul A.W. Edwards, Nicholas Robert Lemoine;
Non-random chromosomal rearrangements in pancreatic cancer cell lines identified by spectral karyotyping.
Int. J. Cancer 91:350-358(2001)

PubMed=11787853; DOI=10.1007/s004280100474
Patrick S. Moore, Bence Sipos, Simonetta Orlandini, Claudio Sorio, Francisco X. Real, Nicholas Robert Lemoine, Thomas M. Gress, Claudio Bassi, Gunter Kloppel, Holger Kalthoff, Hendrik Ungefroren ...Show all 13 authors... , Johannes-Matthias Lohr, Aldo Scarpa; Show fewer authors
Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4.
Virchows Arch. 439:798-802(2001)

PubMed=12692724; DOI=10.1007/s00428-003-0784-4
Bence Sipos, Simone Moser, Holger Kalthoff, Virag Torok, Johannes-Matthias Lohr, Gunter Kloppel;
A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform.
Virchows Arch. 442:444-452(2003)

PubMed=14695172
Christine A. Iacobuzio-Donahue, Raheela Ashfaq, Anirban Maitra, Nazmi Volkan Adsay, Grace L.-C. Shen-Ong, Karin Berg, Michael Anthony Hollingsworth, John Lemuel Cameron, Charles J. Yeo, Scott E. Kern, Michael Gilbert Goggins, Ralph H. Hruban;
Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologies.
Cancer Res. 63:8614-8622(2003)

PubMed=15126341; DOI=10.1158/0008-5472.CAN-03-3159
Markus Heidenblad, Eric F.P.M. Schoenmakers, Tord Jonson, Ludmila Gorunova, Joris A. Veltman, Ad Geurts van Kessel, Mattias Hoglund;
Genome-wide array-based comparative genomic hybridization reveals multiple amplification targets and novel homozygous deletions in pancreatic carcinoma cell lines.
Cancer Res. 64:3052-3059(2004)

PubMed=15367885; DOI=10.1097/00006676-200410000-00004
Panayiotis Loukopoulos, Kengo Kanetaka, Masaaki Takamura, Tatsuhiro Shibata, Michiie Sakamoto, Setsuo Hirohashi;
Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity.
Pancreas 29:193-203(2004)

PubMed=15688027; DOI=10.1038/sj.onc.1208383
Markus Heidenblad, David Lindgren, Joris A. Veltman, Tord Jonson, Eija H. Mahlamaki, Ludmila Gorunova, Ad Geurts van Kessel, Eric F.P.M. Schoenmakers, Mattias Hoglund;
Microarray analyses reveal strong influence of DNA copy number alterations on the transcriptional patterns in pancreatic cancer: implications for the interpretation of genomic amplifications.
Oncogene 24:1794-1801(2005)

PubMed=15770730; DOI=10.3748/wjg.v11.i10.1521; PMCID=PMC4305696
Jian-Hua Ma, Emilia Patrut, Jan Schmidt, Hanns-Peter Knaebel, Markus Wolfgang Buchler, Alexandra Marten;
Synergistic effects of interferon-alpha in combination with chemoradiation on human pancreatic adenocarcinoma.
World J. Gastroenterol. 11:1521-1528(2005)

PubMed=16912165; DOI=10.1158/0008-5472.CAN-06-0721
Eric S. Calhoun, Tomas Hucl, Eike Gallmeier, Kristen M. West, Dan E. Arking, Anirban Maitra, Christine A. Iacobuzio-Donahue, Aravinda Chakravarti, Ralph H. Hruban, Scott E. Kern;
Identifying allelic loss and homozygous deletions in pancreatic cancer without matched normals using high-density single-nucleotide polymorphism arrays.
Cancer Res. 66:7920-7928(2006)

PubMed=18298655; DOI=10.1111/j.1582-4934.2008.00289.x; PMCID=PMC3828895
Christian Pilarsky, Ole Ammerpohl, Bence Sipos, Edgar Dahl, Arndt Hartmann, Axel Wellmann, Till Braunschweig, Johannes-Matthias Lohr, Ralf Jesenofsky, Helmut Friess, Moritz Nicolas Wente ...Show all 20 authors... , Glen Kristiansen, Beatrix Jahnke, Axel Denz, Felix Ruckert, Hans Konrad Schackert, Gunter Kloppel, Holger Kalthoff, Hans-Detlev Saeger, Robert Grutzmann; Show fewer authors
Activation of Wnt signalling in stroma from pancreatic cancer identified by gene expression profiling.
J. Cell. Mol. Med. 12:2823-2835(2008)

PubMed=18380791; DOI=10.1111/j.1349-7006.2008.00779.x; PMCID=PMC11158928
Ayako Suzuki, Tatsuhiro Shibata, Yutaka Shimada, Yoshinori Murakami, Akira Horii, Keiko Shiratori, Setsuo Hirohashi, Johji Inazawa, Issei Imoto;
Identification of SMURF1 as a possible target for 7q21.3-22.1 amplification detected in a pancreatic cancer cell line by in-house array-based comparative genomic hybridization.
Cancer Sci. 99:986-994(2008)

DOI=10.22029/jlupub-12385
Laura Oberlin;
Treatment of pancreatic carcinoma cell lines in vitro and vivo with a monoclonal antibody against the transferrin receptor.
Thesis VMD (2009); Justus-Liebig-Universitat Giessen; Giessen; Germany

DOI=10.4172/jpb.1000057
Masayo Yamada, Kiyonaga Fujii, Koji Koyama, Setsuo Hirohashi, Tadashi Kondo;
The proteomic profile of pancreatic cancer cell lines corresponding to carcinogenesis and metastasis.
J. Proteomics Bioinformatics 2:1-18(2009)

PubMed=20037478; DOI=10.4161/cbt.8.21.9685; PMCID=PMC2824894
Oliver A. Kent, Michael E. Mullendore, Eric A. Wentzel, Pedro Lopez-Romero, Aik-Choon Tan, Hector Alvarez, Kristen M. West, Michael F. Ochs, Manuel Hidalgo, Dan E. Arking, Anirban Maitra, Joshua T. Mendell;
A resource for analysis of microRNA expression and function in pancreatic ductal adenocarcinoma cells.
Cancer Biol. Ther. 8:2013-2024(2009)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20418756; DOI=10.1097/MPA.0b013e3181c15963; PMCID=PMC2860631
Emily L. Deer, Jessica Gonzalez-Hernandez, Jill D. Coursen, Jill E. Shea, Josephat Gichuhi Ngatia, Courtney Lynne Scaife, Matthew A. Firpo, Sean Jordan Mulvihill;
Phenotype and genotype of pancreatic cancer cell lines.
Pancreas 39:425-435(2010)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22585861; DOI=10.1158/2159-8290.CD-11-0224; PMCID=PMC5057396
Richard Marcotte, Kevin R. Brown, Fernando Jose Suarez Saiz, Azin Sayad, Konstantina Karamboulas, Paul M. Krzyzanowski, Fabrice Sircoulomb, Mauricio Medrano, Yaroslav Fedyshyn, Judice Lie-Yong Koh, Dewald van Dyk ...Show all 28 authors... , Bohdana Fedyshyn, Marianna Luhova, Glauber C. Brito, Franco J. Vizeacoumar, Frederick S. Vizeacoumar, Alessandro Datti, Dahlia Kasimer, Alla Buzina, Patricia Mero, Christine Misquitta, Josee Normand, Maliha Haider, Troy Ketela, Jeffrey L. Wrana, Robert Rottapel, Benjamin G. Neel, Jason Moffat; Show fewer authors
Essential gene profiles in breast, pancreatic, and ovarian cancer cells.
Cancer Discov. 2:172-189(2012)

DOI=10.4172/2324-9293.1000104
Markus Udo Wagenhauser, Felix Ruckert, Marco Niedergethmann, Robert Grutzmann, Hans-Detlev Saeger;
Distribution of characteristic mutations in native ductal adenocarcinoma of the pancreas and pancreatic cancer cell lines.
Cell Biol. Res. Ther. 2:1000104.1-1000104.5(2013)

PubMed=25167228; DOI=10.1038/bjc.2014.475; PMCID=PMC4453732
Habib Hamidi, Ming Lu, Kevin Chau, Lee Anderson, Marlena Schoenberg Fejzo, Charles Ginther, Ronald Linnartz, Angela Zubel, Dennis Joseph Slamon, Richard Samuel Finn;
KRAS mutational subtype and copy number predict in vitro response of human pancreatic cancer cell lines to MEK inhibition.
Br. J. Cancer 111:1788-1801(2014)

PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652
Glenn S. Cowley, Barbara A. Weir, Francisca Vazquez, Pablo Tamayo, Justine A. Scott, Scott Rusin, Alexandra East-Seletsky, Levi D. Ali, William F.J. Gerath, Sarah E. Pantel, Patrick Hall Lizotte ...Show all 40 authors... , Guo-Zhi Jiang, Jessica Hsiao, Aviad Tsherniak, Elizabeth Dwinell, Simon Aoyama, Michael Okamoto, William Harrington, Ellen T. Gelfand, Thomas M. Green, Mark J. Tomko, Shuba Gopal, Terence C. Wong, Hu-Bo Li, Sara Howell, Nicolas Stransky, Ted Liefeld, Dongkeun Jang, Jonathan Bistline, Barbara Hill Meyers, Scott Allen Armstrong, Kenneth Carl Anderson, Kimberly Stegmaier, Michael Reich, David Pellman, Jesse S. Boehm, Jill P. Mesirov, Todd Robert Golub, David E. Root, William Chun Hahn; Show fewer authors
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035.1-140035.12(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26216984; DOI=10.1073/pnas.1501605112; PMCID=PMC4538616
Anneleen Daemen, David Peterson, Nisebita Sahu, Ron McCord, Xiang-Nan Du, Bonnie Liu, Katarzyna Kowanetz, Rebecca Hong, John Moffat, Min Gao, Aaron Boudreau ...Show all 22 authors... , Rana Mroue, Laura Corson, Thomas O'Brien, Jing Qing, Deepak Sampath, Mark Merchant, Robert L. Yauch, Gerard Manning, Jeffrey Settleman, Georgia Hatzivassiliou, Marie Evangelista; Show fewer authors
Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors.
Proc. Natl. Acad. Sci. U.S.A. 112:E4410-E4417(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=26586397; DOI=10.1007/s13277-015-4405-z
Jing Zhang, Dong-Mei Wang, Na Hu, Qian Wang, Shanice Yu, Jun Wang;
The construction and proliferative effects of a lentiviral vector capable of stably overexpressing SPINK1 gene in human pancreatic cancer AsPC-1 cell line.
Tumor Biol. 37:5847-5855(2016)

PubMed=27259358; DOI=10.1074/mcp.M116.058313; PMCID=PMC4974343
Emily S. Humphrey, Shih-Ping Su, Adnan M. Nagrial, Falko Hochgrafe, Marina Pajic, Gillian M. Lehrbach, Robert G. Parton, Alpha S. Yap, Lisa G. Horvath, David K. Chang, Andrew Victor Biankin ...Show all 13 authors... , Jian-Min Wu, Roger J. Daly; Show fewer authors
Resolution of novel pancreatic ductal adenocarcinoma subtypes by global phosphotyrosine profiling.
Mol. Cell. Proteomics 15:2671-2685(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=27910856; DOI=10.1038/cgt.2016.71; PMCID=PMC5159445
Roman Mezencev, Lilya V. Matyunina, G.T. Wagner, John F. McDonald;
Acquired resistance of pancreatic cancer cells to cisplatin is multifactorial with cell context-dependent involvement of resistance genes.
Cancer Gene Ther. 23:446-453(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29444439; DOI=10.1016/j.celrep.2018.01.051; PMCID=PMC6343826
Tina L. Yuan, Arnaud Amzallag, Rachel Bagni, Ming Yi, Shervin Afghani, William Burgan, Nicole Fer, Leslie A. Strathern, Katie Powell, Brian Smith, Andrew Michael Waters ...Show all 30 authors... , David Alan Drubin, Ty Thomson, Rosy Liao, Patricia Greninger, Giovanna T. Stein, Ellen Murchie, Eliane Cortez, Regina K. Egan, Lauren Procter, Matthew Bess, Kwong Tai Cheng, Chih-Shia Lee, Liam Changwoo Lee, Christof Fellmann, Robert Stephens, Ji Luo, Scott William Lowe, Cyril Henri Benes, Frank McCormick; Show fewer authors
Differential effector engagement by oncogenic KRAS.
Cell Rep. 22:1889-1902(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Fiona M. Behan, Francesco Iorio, Gabriele Picco, Emanuel Goncalves, Charlotte M. Beaver, Giorgia Migliardi, Rita Santos, Yanhua Rao, Francesco Sassi, Marika Pinnelli, Rizwan Ansari ...Show all 25 authors... , Sarah Harper, David Adam Jackson, Rebecca McRae, Rachel Pooley, Piers Wilkinson, Dieudonne J. van der Meer, David Dow, Carolyn A. Buser-Doepner, Andrea Bertotti, Livio Trusolino, Euan Alexander Stronach, Julio Saez-Rodriguez, Kosuke Yusa, Mathew J. Garnett; Show fewer authors
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
David Paul Nusinow, John Szpyt, Mahmoud Ghandi, Christopher M. Rose, E. Robert McDonald 3rd, Marian Kalocsay, Judit Jane-Valbuena, Ellen T. Gelfand, Devin K. Schweppe, Mark P. Jedrychowski, Javad Golji ...Show all 20 authors... , Dale A. Porter, Tomas Rejtar, Y. Karen Wang, Gregory V. Kryukov, Frank Stegmeier, Brian K. Erickson, Levi Alexander Garraway, William Raj Sellers, Steven P. Gygi; Show fewer authors
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

PubMed=32782605; DOI=10.3892/ol.2020.11825; PMCID=PMC7400074
Kohji Takagi, Johji Imura, Akiko Shimomura, Akira Noguchi, Takashi Minamisaka, Shinichi Tanaka, Takeshi Nishida, Hideki Hatta, Takahiko Nakajima;
Establishment of highly invasive pancreatic cancer cell lines and the expression of IL-32.
Oncol. Lett. 20:2888-2896(2020)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) AddexBio; C0018023/5061
ATCC; CRL-1682
BCRC; 60494
CLS; 300158
ECACC; 96020930
IBRC; C10154
IZSLER; BS TCL 171
KCLB; 21682
NCBI_Iran; C558
Cell line databases/resources CLO; CLO_0001756
MCCL; MCC:0000044
CLDB; cl289
cancercelllines; CVCL_0152
CCRID; 1101HUM-PUMC000214
CCRID; 3101HUMTCHu8
Cell_Model_Passport; SIDM00899
CGH-DB; 160-1
CGH-DB; 9271-4
Cosmic-CLP; 910702
DepMap; ACH-000222
IGRhCellID; AsPC1
LINCS_LDP; LCL-1730
SKY/M-FISH/CGH; 1997
Anatomy/cell type resources BTO; BTO_0001864
Biological sample resources BioSample; SAMN03471961
BioSample; SAMN10988235
CRISP screens repositories BioGRID_ORCS_Cell_line; 259
Chemistry resources ChEMBL-Cells; CHEMBL3307994
ChEMBL-Targets; CHEMBL612588
GDSC; 910702
PharmacoDB; AsPC1_67_2019
PubChem_Cell_line; CVCL_0152
Encyclopedic resources Wikidata; Q54750736
Experimental variables resources EFO; EFO_0002112
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM206446
GEO; GSM383935
GEO; GSM495808
GEO; GSM621911
GEO; GSM784702
GEO; GSM886870
GEO; GSM887935
GEO; GSM1024396
GEO; GSM1177959
GEO; GSM1177960
GEO; GSM1177961
GEO; GSM1374394
GEO; GSM1374395
GEO; GSM1374396
GEO; GSM1588607
GEO; GSM1588619
GEO; GSM1669603
GEO; GSM1906985
GEO; GSM1906986
GEO; GSM1906987
Polymorphism and mutation databases Cosmic; 707247
Cosmic; 710851
Cosmic; 724645
Cosmic; 808166
Cosmic; 868239
Cosmic; 872994
Cosmic; 910702
Cosmic; 913308
Cosmic; 918050
Cosmic; 922255
Cosmic; 923164
Cosmic; 932514
Cosmic; 933515
Cosmic; 947398
Cosmic; 948371
Cosmic; 948740
Cosmic; 949230
Cosmic; 1006364
Cosmic; 1090374
Cosmic; 1108341
Cosmic; 1198210
Cosmic; 1320465
Cosmic; 1366285
Cosmic; 1477433
Cosmic; 1571783
Cosmic; 1644318
Cosmic; 1995341
Cosmic; 2434085
Cosmic; 2668289
IARC_TP53; 311
IARC_TP53; 21127
LiGeA; CCLE_008
Progenetix; CVCL_0152
Proteomic databases PRIDE; PXD003198
PRIDE; PXD030304
PRIDE; PXD032263
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number48