Cellosaurus logo
expasy logo

Cellosaurus MPanc-96 (CVCL_7165)

[Text version]
Cell line name MPanc-96
Synonyms Mpanc-96; MPanc96; mPanc96; MPANC96
Accession CVCL_7165
Resource Identification Initiative To cite this cell line use: MPanc-96 (RRID:CVCL_7165)
Comments Problematic cell line: Contaminated. Shown to be a AsPC-1 derivative (PubMed=20143388). Originally thought to originate from a 67 year old male patient with a poorly differentiated primary pancreatic adenocarcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00329.
Population: Caucasian.
Doubling time: 27 hours (PubMed=9185703).
Omics: Proteome analysis by 2D-DE/MS.
Misspelling: Mpan96; Cosmic=1299303.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Gene deletion; HGNC; 6844; MAP2K4; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Leu78Hisfs*41 (c.233_234delTC) (p.His93Profs*67, c.276_277delTC); ClinVar=VCV000977782; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Homozygous (PubMed=15367885).
  • Mutation; HGNC; 6770; SMAD4; Simple; p.Arg100Thr (c.299G>C); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Cys135Alafs*35 (c.403delT); ClinVar=VCV001069265; Zygosity=Heterozygous (PubMed=15367885).
Disease Pancreatic ductal adenocarcinoma (NCIt: C9120)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0152 (AsPC-1)
Sex of cell Female
Age at sampling 62Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2380


Run an STR similarity search on this cell line
Web pages https://www.atcc.org/en/support/technical-support/faqs/mpanc-96-atcc-crl-2380

PubMed=9185703; DOI=10.1002/(SICI)1097-0215(19970611)71:6<993::AID-IJC15>3.0.CO;2-7
Peiper M., Nagoshi M., Patel D., Fletcher J.A., Goegebuure P.S., Eberlein T.J.
Human pancreatic cancer cells (MPanc-96) recognized by autologous tumor-infiltrating lymphocytes after in vitro as well as in vivo tumor expansion.
Int. J. Cancer 71:993-999(1997)

PubMed=15367885; DOI=10.1097/00006676-200410000-00004
Loukopoulos P., Kanetaka K., Takamura M., Shibata T., Sakamoto M., Hirohashi S.
Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity.
Pancreas 29:193-203(2004)

Yamada M., Fujii K., Koyama K., Hirohashi S., Kondo T.
The proteomic profile of pancreatic cancer cell lines corresponding to carcinogenesis and metastasis.
J. Proteomics Bioinformatics 2:1-18(2009)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cell line collections (Providers) ATCC; CRL-2380 - Discontinued
Cell line databases/resources cancercelllines; CVCL_7165
Biological sample resources BioSample; SAMN03151612
Encyclopedic resources Wikidata; Q54906434
Gene expression databases GEO; GSM784704
Polymorphism and mutation databases Cosmic; 913309
Cosmic; 1299303
Cosmic; 1571780
IARC_TP53; 20487
Progenetix; CVCL_7165
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number30