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Cellosaurus MPanc-96 (CVCL_7165)

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Cell line name MPanc-96
Synonyms Mpanc-96; MPanc96; mPanc96; MPANC96
Accession CVCL_7165
Resource Identification Initiative To cite this cell line use: MPanc-96 (RRID:CVCL_7165)
Comments Problematic cell line: Contaminated. Shown to be a AsPC-1 derivative (PubMed=20143388). Originally thought to originate from a 67 year old male patient with a poorly differentiated primary pancreatic adenocarcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00329.
Population: Caucasian.
Doubling time: 27 hours (PubMed=9185703).
Omics: Proteomics; 2DE-MS.
Misspelling: Mpan96; Cosmic=1299303.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Gene deletion; HGNC; HGNC:6844; MAP2K4; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Leu78Hisfs*41 (c.233_234delTC) (p.His93Profs*67, c.276_277delTC); ClinVar=VCV000977782; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Homozygous (PubMed=15367885).
  • Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Arg100Thr (c.299G>C); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys135Alafs*35 (c.403delT); ClinVar=VCV001069265; Zygosity=Heterozygous (PubMed=15367885).
Disease Pancreatic ductal adenocarcinoma (NCIt: C9120)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0152 (AsPC-1)
Sex of cell Female
Age at sampling 62Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2380

Markers:
AmelogeninX
CSF1PO10,13
D5S81812
D7S82012,13
D13S3179,12
D16S53911
TH017,9.3
TPOX8,10
vWA17

Run an STR similarity search on this cell line
Web pages Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/mpanc-96-atcc-crl-2380
Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=9185703; DOI=10.1002/(SICI)1097-0215(19970611)71:6<993::AID-IJC15>3.0.CO;2-7
Matthias Peiper, Makoto Nagoshi, Dipak Patel, Jonathan A. Fletcher, Peter S. Goegebuure, Timothy J. Eberlein;
Human pancreatic cancer cells (MPanc-96) recognized by autologous tumor-infiltrating lymphocytes after in vitro as well as in vivo tumor expansion.
Int. J. Cancer 71:993-999(1997)

PubMed=15367885; DOI=10.1097/00006676-200410000-00004
Panayiotis Loukopoulos, Kengo Kanetaka, Masaaki Takamura, Tatsuhiro Shibata, Michiie Sakamoto, Setsuo Hirohashi;
Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity.
Pancreas 29:193-203(2004)

DOI=10.4172/jpb.1000057
Masayo Yamada, Kiyonaga Fujii, Koji Koyama, Setsuo Hirohashi, Tadashi Kondo;
The proteomic profile of pancreatic cancer cell lines corresponding to carcinogenesis and metastasis.
J. Proteomics Bioinformatics 2:1-18(2009)

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Cell line collections (Providers) ATCC; CRL-2380 - Discontinued
Cell line databases/resources cancercelllines; CVCL_7165
Biological sample resources BioSample; SAMN03151612
Encyclopedic resources Wikidata; Q54906434
Gene expression databases GEO; GSM784704
Polymorphism and mutation databases Cosmic; 913309
Cosmic; 1299303
Cosmic; 1571780
IARC_TP53; 20487
Progenetix; CVCL_7165
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number32