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Cellosaurus A549L6 (CVCL_ZX74)

[Text version]
Cell line name A549L6
Accession CVCL_ZX74
Resource Identification Initiative To cite this cell line use: A549L6 (RRID:CVCL_ZX74)
Comments Group: Patented cell line.
Registration: International Depositary Authority, China Center for Type Culture Collection; CCTCC C201346.
Population: Caucasian.
Characteristics: Highly metastatic to spine. Established after 3 rounds of intracardial injection of the parent cell line in nude mice and extraction of the metastatic cells from spine tumors.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Firefly luciferase.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_ZX73 (A549L0)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=26090868; DOI=10.18632/oncotarget.4416; PMCID=PMC4673208
Cai X.-P., Luo J., Yang X.-H., Deng H.-Y., Zhang J.-S., Li S.-C., Wei H.-F., Yang C., Xu L.-Q., Jin R.-R., Li Z.-X., Zhou W., Ding J.-D., Chu J.-J., Jia L.-S., Jia Q., Tan C.-J., Liu M.-Y., Xiao J.-R.
In vivo selection for spine-derived highly metastatic lung cancer cells is associated with increased migration, inflammation and decreased adhesion.
Oncotarget 6:22905-22917(2015)

Patent=CN103756968B
Luo J., Xiao J.-R., Liu M.-Y., Cai X.-P.
Spinal highly-metastatic human lung adenocarcinoma cell strain and construction process thereof and application.
Patent number CN103756968B, 20-Jan-2016

Cross-references
Cell line databases/resources cancercelllines; CVCL_ZX74
Encyclopedic resources Wikidata; Q102113493
Entry history
Entry creation29-Oct-2020
Last entry update19-Dec-2024
Version number9