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Cellosaurus A549L6 (CVCL_ZX74)

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Cell line name A549L6
Accession CVCL_ZX74
Resource Identification Initiative To cite this cell line use: A549L6 (RRID:CVCL_ZX74)
Comments Group: Patented cell line.
Registration: International Depositary Authority, China Center for Type Culture Collection; CCTCC C201346.
Population: Caucasian.
Characteristics: Highly metastatic to spine. Established after 3 rounds of intracardial injection of the parent cell line in nude mice and extraction of the metastatic cells from spine tumors.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_ZX73 (A549L0)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=26090868; DOI=10.18632/oncotarget.4416; PMCID=PMC4673208
Xiao-Pan Cai, Jian Luo, Xing-Hai Yang, Hua-Yun Deng, Ji-Shen Zhang, Shi-Chang Li, Hai-Feng Wei, Cheng Yang, Le-Qin Xu, Rong-Rong Jin, Zhen-Xi Li ...Show all 19 authors... , Wang Zhou, Jian-Dong Ding, Jian-Jun Chu, Lian-Shun Jia, Qi Jia, Cheng-Jun Tan, Ming-Yao Liu, Jian-Ru Xiao; Show fewer authors
In vivo selection for spine-derived highly metastatic lung cancer cells is associated with increased migration, inflammation and decreased adhesion.
Oncotarget 6:22905-22917(2015)

Patent=CN103756968B
Jian Luo, Jian-Ru Xiao, Ming-Yao Liu, Xiao-Pan Cai;
Spinal highly-metastatic human lung adenocarcinoma cell strain and construction process thereof and application.
Patent number CN103756968B, 20-Jan-2016

Cross-references
Cell line databases/resources cancercelllines; CVCL_ZX74
Encyclopedic resources Wikidata; Q102113493
Entry history
Entry creation29-Oct-2020
Last entry update14-Aug-2025
Version number10