ID   A549L6
AC   CVCL_ZX74
DR   cancercelllines; CVCL_ZX74
DR   Wikidata; Q102113493
RX   Patent=CN103756968B;
RX   PubMed=26090868;
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, China Center for Type Culture Collection; CCTCC C201346.
CC   Population: Caucasian.
CC   Characteristics: Highly metastatic to spine. Established after 3 rounds of intracardial injection of the parent cell line in nude mice and extraction of the metastatic cells from spine tumors.
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_ZX73 ! A549L0
SX   Male
AG   58Y
CA   Cancer cell line
DT   Created: 29-10-20; Last updated: 14-08-25; Version: 10
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RX   Patent=CN103756968B;
RA   Luo, Jian
RA   Xiao, Jian-Ru
RA   Liu, Ming-Yao
RA   Cai, Xiao-Pan
RT   "Spinal highly-metastatic human lung adenocarcinoma cell strain and
RT   construction process thereof and application.";
RL   Patent number CN103756968B, 20-Jan-2016.
//
RX   PubMed=26090868; DOI=10.18632/oncotarget.4416; PMCID=PMC4673208;
RA   Cai, Xiao-Pan
RA   Luo, Jian
RA   Yang, Xing-Hai
RA   Deng, Hua-Yun
RA   Zhang, Ji-Shen
RA   Li, Shi-Chang
RA   Wei, Hai-Feng
RA   Yang, Cheng
RA   Xu, Le-Qin
RA   Jin, Rong-Rong
RA   Li, Zhen-Xi
RA   Zhou, Wang
RA   Ding, Jian-Dong
RA   Chu, Jian-Jun
RA   Jia, Lian-Shun
RA   Jia, Qi
RA   Tan, Cheng-Jun
RA   Liu, Ming-Yao
RA   Xiao, Jian-Ru
RT   "In vivo selection for spine-derived highly metastatic lung cancer
RT   cells is associated with increased migration, inflammation and
RT   decreased adhesion.";
RL   Oncotarget 6:22905-22917(2015).
//