Cellosaurus cell line TC-1/A9 (CVCL

Cellosaurus TC-1/A9 (CVCL_ZW99)

Cross-references
Cell line name	TC-1/A9
Synonyms	A9
Accession	CVCL_ZW99
Resource Identification Initiative	To cite this cell line use: TC-1/A9 (RRID:CVCL_ZW99)
Comments	Characteristics: Lacks MHC class I expression. Established from tumors produced by subcutaneous injection of parent cell line (PubMed=12559790). Doubling time: 17.5 hours (PubMed=12559790); 16.2 hours (PubMed=31638243). Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val). Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR). Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6. Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7. Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo. Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16). Derived from site: In situ; Lung; UBERON=UBERON_0002048. Cell type: Epithelial cell; CL=CL_0000066.
Species of origin	Mus musculus (Mouse) (NCBI Taxonomy: 10090) Breed/subspecies: C57BL/6.
Hierarchy	Parent: CVCL_4699 (TC-1 [Mouse lung])
Sex of cell	Sex unspecified
Age at sampling	Age unspecified
Category	Transformed cell line
Publications	PubMed=12559790; DOI=10.1016/S0264-410x(02)00519-4 Michal Smahel, Pavel Sima, Viera Ludvikova, Iuri Marinov, Dana Pokorna, Vladimir Vonka; Immunisation with modified HPV16 E7 genes against mouse oncogenic TC-1 cell sublines with downregulated expression of MHC class I molecules. Vaccine 21:1125-1136(2003) PubMed=31638243; DOI=10.3892/or.2019.7356 Karolina Lhotakova, Adrianna Grzelak, Ingrid Polakova, Julie Vackova, Michal Smahel; Establishment and characterization of a mouse tumor cell line with irreversible downregulation of MHC class I molecules. Oncol. Rep. 42:2826-2835(2019)
Encyclopedic resources	Wikidata; Q102114969
Entry history
Entry creation	29-Oct-2020
Last entry update	14-Aug-2025
Version number	12