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Cellosaurus TC-1 [Mouse lung] (CVCL_4699)

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Cell line name TC-1 [Mouse lung]
Synonyms TC-1[JHU-1]; Tissue Culture-1
Accession CVCL_4699
Resource Identification Initiative To cite this cell line use: TC-1 [Mouse lung] (RRID:CVCL_4699)
Comments Doubling time: 18.2 hours (PubMed=12559790); 18.5 hours (PubMed=31638243).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Cell type: Epithelial cell; CL=CL_0000066.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6.
Hierarchy Children:
CVCL_ZW99 (TC-1/A9)CVCL_ZX00 (TC-1/D11)CVCL_ZX01 (TC-1/dB2m)
CVCL_B6PJ (TC-1/E2)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Transformed cell line
Publications

PubMed=8548765
Ken-Yu Lin, Frank G. Guarnieri, Kevin Finnbar Staveley-O'Carroll, Hyam I. Levitsky, J. Thomas August, Drew Mark Pardoll, Tzyy-Choou Wu;
Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen.
Cancer Res. 56:21-26(1996)

PubMed=12559790; DOI=10.1016/S0264-410x(02)00519-4
Michal Smahel, Pavel Sima, Viera Ludvikova, Iuri Marinov, Dana Pokorna, Vladimir Vonka;
Immunisation with modified HPV16 E7 genes against mouse oncogenic TC-1 cell sublines with downregulated expression of MHC class I molecules.
Vaccine 21:1125-1136(2003)

PubMed=31638243; DOI=10.3892/or.2019.7356
Karolina Lhotakova, Adrianna Grzelak, Ingrid Polakova, Julie Vackova, Michal Smahel;
Establishment and characterization of a mouse tumor cell line with irreversible downregulation of MHC class I molecules.
Oncol. Rep. 42:2826-2835(2019)

Cross-references
Cell line collections (Providers) ATCC; CRL-2785 - Discontinued
ATCC; JHU-1 - Discontinued
NCBI_Iran; C569
Cell line databases/resources CLO; CLO_0009279
Anatomy/cell type resources BTO; BTO_0004795
Encyclopedic resources Wikidata; Q54971787
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number24