ID   TC-1/A9
AC   CVCL_ZW99
SY   A9
DR   Wikidata; Q102114969
RX   PubMed=12559790;
RX   PubMed=31638243;
CC   Characteristics: Lacks MHC class I expression. Established from tumors produced by subcutaneous injection of parent cell line (PubMed=12559790).
CC   Doubling time: 17.5 hours (PubMed=12559790); 16.2 hours (PubMed=31638243).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
CC   Cell type: Epithelial cell; CL=CL_0000066.
CC   Breed/subspecies: C57BL/6.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_4699 ! TC-1 [Mouse lung]
SX   Sex unspecified
AG   Age unspecified
CA   Transformed cell line
DT   Created: 29-10-20; Last updated: 10-04-25; Version: 11
//
RX   PubMed=12559790; DOI=10.1016/S0264-410x(02)00519-4;
RA   Smahel M., Sima P., Ludvikova V., Marinov I., Pokorna D., Vonka V.;
RT   "Immunisation with modified HPV16 E7 genes against mouse oncogenic
RT   TC-1 cell sublines with downregulated expression of MHC class I
RT   molecules.";
RL   Vaccine 21:1125-1136(2003).
//
RX   PubMed=31638243; DOI=10.3892/or.2019.7356;
RA   Lhotakova K., Grzelak A., Polakova I., Vackova J., Smahel M.;
RT   "Establishment and characterization of a mouse tumor cell line with
RT   irreversible downregulation of MHC class I molecules.";
RL   Oncol. Rep. 42:2826-2835(2019).
//