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Cellosaurus 143B rho-0 EtBr (CVCL_ZL52)

[Text version]
Cell line name 143B rho-0 EtBr
Accession CVCL_ZL52
Resource Identification Initiative To cite this cell line use: 143B rho-0 EtBr (RRID:CVCL_ZL52)
Comments Population: Caucasian.
Characteristics: Cell line devoid of mitochondrial DNA (rho0). Obtained by growth of parental cell line with ethidium bromide.
Derived from site: In situ; Bone, right femur; UBERON=UBERON_0000981.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Ala59Thr (c.175G>A); ClinVar=VCV000012581; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg156Pro (c.467G>C); ClinVar=VCV000634768; Zygosity=Homozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2270 (143B)
Sex of cell Female
Age at sampling 13Y
Category Cancer cell line

PubMed=20188060; DOI=10.1016/j.bbabio.2010.02.021
Wittig I., Meyer B., Heide H., Steger M., Bleier L., Wumaier Z., Karas M., Schagger H.
Assembly and oligomerization of human ATP synthase lacking mitochondrial subunits a and A6L.
Biochim. Biophys. Acta 1797:1004-1011(2010)

PubMed=26852163; DOI=10.1074/mcp.M115.053181
Aretz I., Hardt C., Wittig I., Meierhofer D.
An impaired respiratory electron chain triggers down-regulation of the energy metabolism and de-ubiquitination of solute carrier amino acid transporters.
Mol. Cell. Proteomics 15:1526-1538(2016)

Cell line databases/resources cancercelllines; CVCL_ZL52
Encyclopedic resources Wikidata; Q98125110
Proteomic databases PRIDE; PXD002425
Entry history
Entry creation02-Jul-2020
Last entry update05-Oct-2023
Version number8