ID   143B rho-0 EtBr
AC   CVCL_ZL52
DR   cancercelllines; CVCL_ZL52
DR   PRIDE; PXD002425
DR   Wikidata; Q98125110
RX   PubMed=20188060;
RX   PubMed=26852163;
CC   Population: Caucasian.
CC   Characteristics: Cell line devoid of mitochondrial DNA (rho0). Obtained by growth of parental cell line with ethidium bromide.
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Ala59Thr (c.175G>A); ClinVar=VCV000012581; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg156Pro (c.467G>C); ClinVar=VCV000634768; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Bone, right femur; UBERON=UBERON_0000981.
DI   NCIt; C9145; Osteosarcoma
DI   ORDO; Orphanet_668; Osteosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_2270 ! 143B
SX   Female
AG   13Y
CA   Cancer cell line
DT   Created: 02-07-20; Last updated: 19-12-24; Version: 9
//
RX   PubMed=20188060; DOI=10.1016/j.bbabio.2010.02.021;
RA   Wittig, Ilka
RA   Meyer, Bjoern
RA   Heide, Heinrich
RA   Steger, Mirco
RA   Bleier, Lea
RA   Wumaier, Zibiernisha
RA   Karas, Michael
RA   Schagger, Hermann
RT   "Assembly and oligomerization of human ATP synthase lacking
RT   mitochondrial subunits a and A6L.";
RL   Biochim. Biophys. Acta 1797:1004-1011(2010).
//
RX   PubMed=26852163; DOI=10.1074/mcp.M115.053181; PMCID=PMC4858937;
RA   Aretz, Ina
RA   Hardt, Christopher
RA   Wittig, Ilka
RA   Meierhofer, David
RT   "An impaired respiratory electron chain triggers down-regulation of
RT   the energy metabolism and de-ubiquitination of solute carrier amino
RT   acid transporters.";
RL   Mol. Cell. Proteomics 15:1526-1538(2016).
//