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Cellosaurus NFkappaB-TIME (CVCL_Z064)

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Cell line name NFkappaB-TIME
Accession CVCL_Z064
Resource Identification Initiative To cite this cell line use: NFkappaB-TIME (RRID:CVCL_Z064)
Comments Characteristics: The NanoLuc reporter gene is under the control of multiple copies of the NF-kappaB response element (ATCC=CRL-4049).
Characteristics: When cells are exposed to inflammatory cytokines such as TNFalpha, activation of the NF-kappaB signaling pathway occurs resulting in increased luciferase activity (ATCC=CRL-4049).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P33967; Bacillus cereus Bsr.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Genetic integration: Method=Transfection; Gene=Oplophorus gracilirostris NanoLuc (Note=19 kDa ATP-independent bright luminescent protein derived from O.gracilirostris luciferase).
Derived from site: In situ; Foreskin, skin, dermis, microvascular endothelium; UBERON=UBERON_0001471+UBERON_0008339.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0047 (TIME)
Sex of cell Male
Age at sampling <1M
Category Telomerase immortalized cell line
STR profile Source(s): ATCC=CRL-4049

Markers:
AmelogeninX,Y
CSF1PO11,12
D5S81811
D7S8208,9
D13S3179,11
D16S5399,12
TH016,7
TPOX8
vWA16,18

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Cross-references
Cell line collections (Providers) ATCC; CRL-4049
Encyclopedic resources Wikidata; Q54930430
Entry history
Entry creation10-Apr-2015
Last entry update14-Aug-2025
Version number17