ID   NFkappaB-TIME
AC   CVCL_Z064
DR   ATCC; CRL-4049
DR   Wikidata; Q54930430
CC   Characteristics: The NanoLuc reporter gene is under the control of multiple copies of the NF-kappaB response element (ATCC=CRL-4049).
CC   Characteristics: When cells are exposed to inflammatory cytokines such as TNFalpha, activation of the NF-kappaB signaling pathway occurs resulting in increased luciferase activity (ATCC=CRL-4049).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P33967; Bacillus cereus Bsr.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Genetic integration: Method=Transfection; Gene=Oplophorus gracilirostris NanoLuc (Note=19 kDa ATP-independent bright luminescent protein derived from O.gracilirostris luciferase).
CC   Derived from site: In situ; Foreskin, skin, dermis, microvascular endothelium; UBERON=UBERON_0001471+UBERON_0008339.
ST   Source(s): ATCC=CRL-4049
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 9,11
ST   D16S539: 9,12
ST   D5S818: 11
ST   D7S820: 8,9
ST   TH01: 6,7
ST   TPOX: 8
ST   vWA: 16,18
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0047 ! TIME
SX   Male
AG   <1M
CA   Telomerase immortalized cell line
DT   Created: 10-04-15; Last updated: 14-08-25; Version: 17
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