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Cellosaurus TIME (CVCL_0047)

[Text version]
Cell line name TIME
Synonyms Telomerase-Immortalized human Microvascular Endothelial cells
Accession CVCL_0047
Resource Identification Initiative To cite this cell line use: TIME (RRID:CVCL_0047)
Comments Part of: Human Protein Atlas, Cell Atlas panel.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P33967; B.cereus Bsr.
Omics: Proteomics; Expression; Large antibody panel staining analysis.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Foreskin, skin, dermis, microvascular endothelium; UBERON=UBERON_0001471+UBERON_0008339.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_Z064 (NFkappaB-TIME)CVCL_S878 (TIME-GFP)CVCL_B6YR (TIME.219)
Sex of cell Male
Age at sampling <1M
Category Telomerase immortalized cell line
STR profile Source(s): ATCC=CRL-4025; PubMed=33937098

Markers:
AmelogeninX,Y
CSF1PO11,12
D2S133818,20
D3S135814,15
D5S81811
D7S8208,9
D8S117911,13
D13S3179,11
D16S5399,12
D18S5117
D19S43313,15
D21S1130
FGA19,25
Penta D9,13
Penta E7,16
TH016,7
TPOX8
vWA16,18

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Web pages Info; ATCC; -; https://www.atcc.org/-/media/resources/application-notes/telomerase-immortalized-microvascular-endothelial-cells.pdf?rev=1b6ac96d7e8a4778978ebb808a68b1a5
Info; HPA; -; https://www.proteinatlas.org/learn/cellines
Publications

PubMed=11795943; DOI=10.1006/excr.2001.5424
Venetsanakos E., Mirza A., Fanton C., Romanov S.R., Tlsty T., McMahon M.
Induction of tubulogenesis in telomerase-immortalized human microvascular endothelial cells by glioblastoma cells.
Exp. Cell Res. 273:21-33(2002)

PubMed=33937098; DOI=10.3389/fcimb.2021.654396; PMCID=PMC8080876
Dollery S.J., Maldonado T.D., Brenner E.A., Berger E.A.
iTIME.219: an immortalized KSHV infected endothelial cell line inducible by a KSHV-specific stimulus to transition from latency to lytic replication and infectious virus release.
Front. Cell. Infect. Microbiol. 11:654396.1-654396.9(2021)

Cross-references
Cell line collections (Providers) ATCC; CRL-4025
Biological sample resources BioSample; SAMN03471728
CRISP screens repositories BioGRID_ORCS_Cell_line; 1380
Encyclopedic resources Wikidata; Q27653709
Gene expression databases GEO; GSM7701377
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number24