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Cellosaurus IOSE4CMYC (CVCL_YZ56)

[Text version]
Cell line name IOSE4CMYC
Synonyms iOSE4CMYC; IOE4CMYC
Accession CVCL_YZ56
Resource Identification Initiative To cite this cell line use: IOSE4CMYC (RRID:CVCL_YZ56)
Comments Genetic integration: Method=Transduction; Gene=HGNC; HGNC:7553; MYC.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P33967; Bacillus cereus Bsr.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Derived from site: In situ; Ovary, surface epithelium; UBERON=UBERON_0001304.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0T70 (IOSE4)
Sex of cell Female
Age at sampling Age unspecified
Category Telomerase immortalized cell line
Publications

PubMed=20360942; DOI=10.1593/neo.91948; PMCID=PMC2847739
Kate Lawrenson, Barbara Grun, Elizabeth Benjamin, Ian J. Jacobs, Dimitra Dafou, Simon Andrew Gayther;
Senescent fibroblasts promote neoplastic transformation of partially transformed ovarian epithelial cells in a three-dimensional model of early stage ovarian cancer.
Neoplasia 12:317-325(2010)

PubMed=30487138; DOI=10.1158/0008-5472.CAN-17-3864; PMCID=PMC6359979
Melissa A. Buckley, Nicholas T. Woods, Jonathan P. Tyrer, Gustavo Mendoza-Fandino, Kate Lawrenson, Dennis J. Hazelett, Hamed S. Najafabadi, Anxhela Gjyshi, Renato S. Carvalho, Paulo C. Lyra Jr., Simon Gert Coetzee ...Show all 27 authors... , Howard C. Shen, Ally W. Yang, Madalene A. Earp, Sean J. Yoder, Harvey Risch, Georgia Chenevix-Trench, Susan J. Ramus, Catherine M. Phelan, Gerhard A. Coetzee, Houtan Noushmehr, Timothy R. Hughes, Thomas A. Sellers, Ellen L. Goode, Paul D.P. Pharoah, Simon Andrew Gayther, Alvaro N.A. Monteiro; Show fewer authors
Functional analysis and fine mapping of the 9p22.2 ovarian cancer susceptibility locus.
Cancer Res. 79:467-481(2019)

Cross-references
Encyclopedic resources Wikidata; Q98126784
Entry history
Entry creation02-Jul-2020
Last entry update14-Aug-2025
Version number12