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Cellosaurus IOSE4 (CVCL_0T70)

[Text version]
Cell line name IOSE4
Synonyms iOSE4; IOE4; Immortalized Ovarian Surface Epithelial cells 4
Accession CVCL_0T70
Resource Identification Initiative To cite this cell line use: IOSE4 (RRID:CVCL_0T70)
Comments Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Omics: Genomics; ChIP-seq; H3K27ac.
Omics: Genomics; ChIP-seq; H3K4me1.
Derived from site: In situ; Ovary, surface epithelium; UBERON=UBERON_0001304.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_YZ56 (IOSE4CMYC)
Sex of cell Female
Age at sampling Age unspecified
Category Telomerase immortalized cell line
Publications

PubMed=20360942; DOI=10.1593/neo.91948; PMCID=PMC2847739
Kate Lawrenson, Barbara Grun, Elizabeth Benjamin, Ian J. Jacobs, Dimitra Dafou, Simon Andrew Gayther;
Senescent fibroblasts promote neoplastic transformation of partially transformed ovarian epithelial cells in a three-dimensional model of early stage ovarian cancer.
Neoplasia 12:317-325(2010)

PubMed=25804953; DOI=10.1093/hmg/ddv101; PMCID=PMC4459387
Simon Gert Coetzee, Howard C. Shen, Dennis J. Hazelett, Kate Lawrenson, Karoline Kuchenbaecker, Jonathan P. Tyrer, Suhn K. Rhie, Keren Levanon, Alison M. Karst, Ronny I. Drapkin, Susan J. Ramus ...Show all 21 authors... , Fergus J. Couch, Kenneth Offit, Georgia Chenevix-Trench, Alvaro N.A. Monteiro, Antonis Antoniou, Matthew Lawrence Freedman, Gerhard A. Coetzee, Paul D.P. Pharoah, Houtan Noushmehr, Simon Andrew Gayther; Show fewer authors
Consortium of Investigators of Modifiers of BRCA1/2
Ovarian Cancer Association Consortium
Cell-type-specific enrichment of risk-associated regulatory elements at ovarian cancer susceptibility loci.
Hum. Mol. Genet. 24:3595-3607(2015)

PubMed=30487138; DOI=10.1158/0008-5472.CAN-17-3864; PMCID=PMC6359979
Melissa A. Buckley, Nicholas T. Woods, Jonathan P. Tyrer, Gustavo Mendoza-Fandino, Kate Lawrenson, Dennis J. Hazelett, Hamed S. Najafabadi, Anxhela Gjyshi, Renato S. Carvalho, Paulo C. Lyra Jr., Simon Gert Coetzee ...Show all 27 authors... , Howard C. Shen, Ally W. Yang, Madalene A. Earp, Sean J. Yoder, Harvey Risch, Georgia Chenevix-Trench, Susan J. Ramus, Catherine M. Phelan, Gerhard A. Coetzee, Houtan Noushmehr, Timothy R. Hughes, Thomas A. Sellers, Ellen L. Goode, Paul D.P. Pharoah, Simon Andrew Gayther, Alvaro N.A. Monteiro; Show fewer authors
Functional analysis and fine mapping of the 9p22.2 ovarian cancer susceptibility locus.
Cancer Res. 79:467-481(2019)

Cross-references
Encyclopedic resources Wikidata; Q54897914
Gene expression databases GEO; GSM1663040
GEO; GSM1663041
GEO; GSM1663042
GEO; GSM1663043
GEO; GSM1663044
GEO; GSM1663045
GEO; GSM1663046
GEO; GSM1663047
GEO; GSM1663048
GEO; GSM1663049
GEO; GSM1663050
Entry history
Entry creation08-Jul-2015
Last entry update10-Apr-2025
Version number11