ID   IOSE4
AC   CVCL_0T70
SY   iOSE4; IOE4; Immortalized Ovarian Surface Epithelial cells 4
DR   GEO; GSM1663040
DR   GEO; GSM1663041
DR   GEO; GSM1663042
DR   GEO; GSM1663043
DR   GEO; GSM1663044
DR   GEO; GSM1663045
DR   GEO; GSM1663046
DR   GEO; GSM1663047
DR   GEO; GSM1663048
DR   GEO; GSM1663049
DR   GEO; GSM1663050
DR   Wikidata; Q54897914
RX   PubMed=20360942;
RX   PubMed=25804953;
RX   PubMed=30487138;
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Omics: Genomics; ChIP-seq; H3K27ac.
CC   Omics: Genomics; ChIP-seq; H3K4me1.
CC   Derived from site: In situ; Ovary, surface epithelium; UBERON=UBERON_0001304.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   Age unspecified
CA   Telomerase immortalized cell line
DT   Created: 08-07-15; Last updated: 10-04-25; Version: 11
//
RX   PubMed=20360942; DOI=10.1593/neo.91948; PMCID=PMC2847739;
RA   Lawrenson K., Grun B., Benjamin E., Jacobs I.J., Dafou D.,
RA   Gayther S.A.;
RT   "Senescent fibroblasts promote neoplastic transformation of partially
RT   transformed ovarian epithelial cells in a three-dimensional model of
RT   early stage ovarian cancer.";
RL   Neoplasia 12:317-325(2010).
//
RX   PubMed=25804953; DOI=10.1093/hmg/ddv101; PMCID=PMC4459387;
RA   Coetzee S.G., Shen H.C., Hazelett D.J., Lawrenson K.,
RA   Kuchenbaecker K., Tyrer J.P., Rhie S.K., Levanon K., Karst A.M.,
RA   Drapkin R.I., Ramus S.J., Couch F.J., Offit K., Chenevix-Trench G.,
RA   Monteiro A.N.A., Antoniou A., Freedman M.L., Coetzee G.A.,
RA   Pharoah P.D.P., Noushmehr H., Gayther S.A.;
RG   Consortium of Investigators of Modifiers of BRCA1/2;
RG   Ovarian Cancer Association Consortium;
RT   "Cell-type-specific enrichment of risk-associated regulatory elements
RT   at ovarian cancer susceptibility loci.";
RL   Hum. Mol. Genet. 24:3595-3607(2015).
//
RX   PubMed=30487138; DOI=10.1158/0008-5472.CAN-17-3864; PMCID=PMC6359979;
RA   Buckley M.A., Woods N.T., Tyrer J.P., Mendoza-Fandino G.,
RA   Lawrenson K., Hazelett D.J., Najafabadi H.S., Gjyshi A.,
RA   Carvalho R.S., Lyra P.C. Jr., Coetzee S.G., Shen H.C., Yang A.W.,
RA   Earp M.A., Yoder S.J., Risch H., Chenevix-Trench G., Ramus S.J.,
RA   Phelan C.M., Coetzee G.A., Noushmehr H., Hughes T.R., Sellers T.A.,
RA   Goode E.L., Pharoah P.D.P., Gayther S.A., Monteiro A.N.A.;
RT   "Functional analysis and fine mapping of the 9p22.2 ovarian cancer
RT   susceptibility locus.";
RL   Cancer Res. 79:467-481(2019).
//