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Cellosaurus MDCK.STAT1 KO (CVCL_YZ44)

[Text version]
Cell line name MDCK.STAT1 KO
Accession CVCL_YZ44
Resource Identification Initiative To cite this cell line use: MDCK.STAT1 KO (RRID:CVCL_YZ44)
Comments Group: Vaccine production cell line.
Virology: Excellent cell model for virus propagation and viral vaccine production. It exhibits significant increased viral titer and enhanced virus production capability when compared to its parental cell line (ATCC=CCL-34-VHG).
Doubling time: ~22 hours (ATCC=CCL-34-VHG).
Knockout cell: Method=CRISPR/Cas9; VGNC; -; STAT1.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Cell type: Epithelial cell of kidney; CL=CL_0002518.
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Cocker Spaniel.
Hierarchy Parent: CVCL_0422 (MDCK)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line

Turner-Gillies E., Shapiro B.A., Tian F.
Generation of cell lines capable of producing high-titer viral stocks for use in vaccine manufacture and gene therapy.
(In) ATCC application note AP-082021-v01; pp.1-8; ATCC; Manassas (2021)

Cell line collections (Providers) ATCC; CCL-34-VHG
Encyclopedic resources Wikidata; Q98127201
Entry history
Entry creation02-Jul-2020
Last entry update05-Oct-2023
Version number8