Cellosaurus cell line PM1-Luc (CVCL

Cellosaurus PM1-Luc (CVCL_YX97)

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Cell line name

PM1-Luc

Accession

CVCL_YX97

Resource Identification Initiative

To cite this cell line use: PM1-Luc (RRID:CVCL_YX97)

Comments

Population: Caucasian.
Characteristics: The luciferase reporter gene expression is under the control of a Tat-inducible SIV LTR.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.

Sequence variations

Gene deletion; HGNC; HGNC:7208; MPDZ; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Homozygous (from parent cell line).

Disease

Sezary syndrome (NCIt: C3366)
Sezary syndrome (ORDO: Orphanet_3162)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_9472 (PM1)
Children:

CVCL_YX98 (PM1-CCR5-Luc)

Sex of cell

Male

Age at sampling

53Y