Cellosaurus cell line PM1-CCR5-Luc (CVCL

Cellosaurus PM1-CCR5-Luc (CVCL_YX98)

Cross-references
Cell line name	PM1-CCR5-Luc
Accession	CVCL_YX98
Resource Identification Initiative	To cite this cell line use: PM1-CCR5-Luc (RRID:CVCL_YX98)
Comments	Population: Caucasian. Characteristics: The luciferase reporter gene expression is under the control of a Tat-inducible SIV LTR. Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:1606; CCR5. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR). Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: T-cell; CL=CL_0000084.
Sequence variations	Gene deletion; HGNC; HGNC:7208; MPDZ; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Homozygous (from parent cell line).
Disease	Sezary syndrome (NCIt: C3366) Sezary syndrome (ORDO: Orphanet_3162)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_YX97 (PM1-Luc)
Sex of cell	Male
Age at sampling	53Y
Category	Cancer cell line
Publications	PubMed=32135162; DOI=10.1016/j.jim.2020.112766; PMCID=PMC7188583 Allison S. Thomas, Melissa Ghulam-Smith, Alex Olson, Carolyn Coote, Oscar Gonzales, Manish Sagar; A new cell line for assessing HIV-1 antibody dependent cellular cytotoxicity against a broad range of variants. J. Immunol. Methods 480:112766.1-112766.9(2020)
Cell line databases/resources	cancercelllines; CVCL_YX98
Encyclopedic resources	Wikidata; Q98128640
Entry history
Entry creation	12-Mar-2020
Last entry update	14-Aug-2025
Version number	14