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Cellosaurus Sup-T1-CCR5 (CVCL_X633)

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Cell line name Sup-T1-CCR5
Synonyms SupT1/CCR5; SupT1-CCR5
Accession CVCL_X633
Resource Identification Initiative To cite this cell line use: Sup-T1-CCR5 (RRID:CVCL_X633)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:1606; CCR5.
Miscellaneous: STR profile from personal communication of Fernandez, Melissa Victoria.
Caution: There seem to be at least 6 different cell lines derived from Sup-T1 by transfection of human CCR5: Sup-T1-CCR5 (Cellosaurus=CVCL_X633), SupT1.CCR5 (Cellosaurus=CVCL_WU88), SupT1-R5 (Cellosaurus=CVCL_WU89), Sup-T1 CCR5+ H6 (Cellosaurus=CVCL_A9NU), Sup-T1 CCR5+ L23 (Cellosaurus=CVCL_A9NV) and Sup-T1 CCR5+ M10 (Cellosaurus=CVCL_A9NW).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Cys251Tyr (c.752G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6342; KIT; Simple; p.Arg177His (c.530G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7029; MET; Simple; p.Arg191Trp (c.571C>T); ClinVar=VCV000568557; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Asp (c.1635G>T); ClinVar=VCV000217293; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu970Lys (c.2908G>A); ClinVar=VCV001057635; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9585; PTCH1; Simple; p.Arg682Cys (c.2044C>T); ClinVar=VCV000237466; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:15533; SPRY4; Simple; p.Arg25Trp (c.73C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg267Leu (c.800G>T); ClinVar=VCV000852206; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T lymphoblastic lymphoma (NCIt: C7210)
T-cell non-Hodgkin lymphoma (ORDO: Orphanet_171918)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1714 (SUP-T1)
Sex of cell Male
Age at sampling 8Y
Category Cancer cell line
STR profile Source(s): Direct_author_submission

Markers:
AmelogeninX,Y
CSF1PO10,11,12
D3S135816,17,18,19,20
D5S81811
D7S82011
D8S117913,14
D13S31711,12
D16S5399,12,13
D18S5113,14
D21S1127,28,32,33
FGA19,20,21
Penta D12
Penta E14,16
TH019.3
TPOX9
vWA16,17,18,19

Run an STR similarity search on this cell line
Publications

PubMed=11264379; DOI=10.1128/JVI.75.8.3903-3915.2001; PMCID=PMC114881
Robert E. Means, Thomas Matthews, James A. Hoxie, Michael Henry Malim, Toshiaki Kodama, Ronald Charles Desrosiers;
Ability of the V3 loop of simian immunodeficiency virus to serve as a target for antibody-mediated neutralization: correlation of neutralization sensitivity, growth in macrophages, and decreased dependence on CD4.
J. Virol. 75:3903-3915(2001)

Cross-references
Cell line databases/resources cancercelllines; CVCL_X633
Encyclopedic resources Wikidata; Q54970881
Entry history
Entry creation05-Sep-2014
Last entry update19-Dec-2024
Version number18