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Cellosaurus SUP-T1 (CVCL_1714)

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Cell line name SUP-T1
Synonyms Sup-T1; SUPT-1; SupT-1; Sup T-1; SUP T-1; SUP T1; Sup T1; SupT1; SUPT1; Tsup-1; VB; Stanford University Pediatric T-cell line 1
Accession CVCL_1714
Resource Identification Initiative To cite this cell line use: SUP-T1 (RRID:CVCL_1714)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Characteristics: Has chromosomal translocations involving the genes for the alpha and beta subunits of TCR thus preventing surface expression of the endogenous TCR complex.
Virology: Useful for studies of cell fusion and cytopathic effects of HIV-1 as well as cytopathic isolates of HIV-2.
Virology: Susceptible to infection by herpesvirus 6B (HHV-6B) strain Z29 (PubMed=29304865).
Doubling time: 28 hours (PubMed=3004618); ~30 hours (DSMZ=ACC-140); ~24-36 hours (BEI_Resources=ARP-100).
Microsatellite instability: Stable (MSS) (Sanger).
Microsatellite instability: Instable (MSI) (PubMed=31068700).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq virome analysis.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Cys251Tyr (c.752G>A); Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP=909743).
  • Mutation; HGNC; HGNC:6342; KIT; Simple; p.Arg177His (c.530G>A); Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP=909743).
  • Mutation; HGNC; HGNC:7029; MET; Simple; p.Arg191Trp (c.571C>T); ClinVar=VCV000568557; Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP=909743).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Asp (c.1635G>T); ClinVar=VCV000217293; Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP=909743).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu970Lys (c.2908G>A); ClinVar=VCV001057635; Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP=909743).
  • Mutation; HGNC; HGNC:9585; PTCH1; Simple; p.Arg682Cys (c.2044C>T); ClinVar=VCV000237466; Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP=909743).
  • Mutation; HGNC; HGNC:15533; SPRY4; Simple; p.Arg25Trp (c.73C>T); Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP=909743; DepMap=ACH-000953).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg267Leu (c.800G>T); ClinVar=VCV000852206; Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP=909743).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.14
Native American1.61
East Asian, North0
East Asian, South0
South Asian9.49
European, North46.77
European, South41.99
Disease Childhood T lymphoblastic lymphoma (NCIt: C7210)
T-cell non-Hodgkin lymphoma (ORDO: Orphanet_171918)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_1E03 (BC7)CVCL_A9NU (Sup-T1 CCR5+ H6)CVCL_A9NV (Sup-T1 CCR5+ L23)
CVCL_A9NW (Sup-T1 CCR5+ M10)CVCL_1H35 (Sup-T1 Nef-ER 31)CVCL_X633 (Sup-T1-CCR5)
CVCL_M773 (Sup-T1/JI)CVCL_M772 (SUP-T1/Z29)CVCL_C6JB (SupT1-CIITA)
CVCL_WU89 (SupT1-R5)CVCL_WU88 (SupT1.CCR5)CVCL_WV22 (SupT1/Blam)
Sex of cell Male
Age at sampling 8Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-1942; Cosmic-CLP=909743; DSMZ=ACC-140; PubMed=32938764

Markers:
AmelogeninX (DSMZ=ACC-140)
X,Y (ATCC=CRL-1942; Cosmic-CLP=909743; PubMed=32938764)
CSF1PO10,11 (ATCC=CRL-1942; Cosmic-CLP=909743; DSMZ=ACC-140)
10,11,12 (PubMed=32938764)
D2S133825,26
D3S135816,17,18,19 (PubMed=32938764)
17 (DSMZ=ACC-140)
D5S81810,11,12 (DSMZ=ACC-140)
11 (PubMed=32938764)
11,12 (ATCC=CRL-1942; Cosmic-CLP=909743)
D7S82011
D8S117913,14 (PubMed=32938764)
13,14,15 (DSMZ=ACC-140)
D13S31710,11,12 (DSMZ=ACC-140; PubMed=32938764)
11,12 (ATCC=CRL-1942; Cosmic-CLP=909743)
D16S5399,10,11,13 (DSMZ=ACC-140)
9,11,12 (ATCC=CRL-1942; Cosmic-CLP=909743)
9,12 (PubMed=32938764)
D18S5113,14
D19S43313,27
D21S1128,29,32.2,33.2 (DSMZ=ACC-140)
28,31,32,33 (PubMed=32938764)
FGA19,20,21 (PubMed=32938764)
20,21 (DSMZ=ACC-140)
Penta D12
Penta E13,14,16 (PubMed=32938764)
14,16 (DSMZ=ACC-140)
TH019.3
TPOX8,9 (DSMZ=ACC-140)
9 (ATCC=CRL-1942; Cosmic-CLP=909743; PubMed=32938764)
vWA16,17,18,19 (PubMed=32938764)
16,18 (ATCC=CRL-1942; Cosmic-CLP=909743)
16,18,19 (DSMZ=ACC-140)

Run an STR similarity search on this cell line
Web pages Info; T-ALL cell lines db; -; https://humantallcelllines.wordpress.com/comprehensivetable/sup-t1/
Provider; HHV-6 Foundation; -; https://hhv-6foundation.org/wp-content/uploads/2016/11/SupT-1-Cells-data-sheet.pdf
Provider; NIBSC; 0024; http://www.nibsc.org/Default.aspx?pageid=597&id=0024&theme=default
Publications

PubMed=6437672
Stephen D. Smith, Margaret Shatsky, Pamela S. Cohen, Roger Allen Warnke, Michael P. Link, Bertil E. Glader;
Monoclonal antibody and enzymatic profiles of human malignant T-lymphoid cells and derived cell lines.
Cancer Res. 44:5657-5660(1984)

PubMed=6438800; DOI=10.1126/science.6438800
Frederick Hecht, Rodman Morgan, Barbara Kaiser-McCaw Hecht, Stephen D. Smith;
Common region on chromosome 14 in T-cell leukemia and lymphoma.
Science 226:1445-1447(1984)

PubMed=3935328; DOI=10.1016/0092-8674(85)90243-0
Richard Baer, Kuey-Chu Chen, Stephen D. Smith, Terence Howard Rabbitts;
Fusion of an immunoglobulin variable gene and a T cell receptor constant gene in the chromosome 14 inversion associated with T cell tumors.
Cell 43:705-713(1985)

PubMed=3004618; DOI=10.1182/blood.V67.3.650.650
Stephen D. Smith, Rodman Morgan, Michael P. Link, Pam McFall, Frederick Hecht;
Cytogenetic and immunophenotypic analysis of cell lines established from patients with T cell leukemia/lymphoma.
Blood 67:650-656(1986)

PubMed=3010463; DOI=10.1126/science.3010463
Jeffrey D. Lifson, Gregory R. Reyes, Michael S. McGrath, Barry Stanley Stein, Edgar G. Engleman;
AIDS retrovirus induced cytopathology: giant cell formation and involvement of CD4 antigen.
Science 232:1123-1127(1986)

PubMed=3036367; DOI=10.1016/0092-8674(87)90666-0
Richard Baer, Alan Forster, Terence Howard Rabbitts;
The mechanism of chromosome 14 inversion in a human T cell lymphoma.
Cell 50:97-105(1987)

PubMed=3107838; DOI=10.1016/0092-8674(87)90542-3
Barry Stanley Stein, Shantharaj D. Gowda, Jeffrey D. Lifson, Robert C. Penhallow, Klaus George Bensch, Edgar G. Engleman;
pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane.
Cell 49:659-668(1987)

PubMed=7849311; DOI=10.1182/blood.V85.4.893.bloodjournal854893
Gail Stranks, Susan E. Height, Paul Mitchell, Dalal Mouneimne Jadayel, Martin A.R. Yuille, Corinne F.M. De Lord, Robyn D. Clutterbuck, Jennie G. Treleaven, Ray Leonard Powles, Elisabeth Nacheva, David G. Oscier ...Show all 17 authors... , Abraham Karpas, Gilbert Marcel Lenoir, Stephen D. Smith, John L. Millar, Daniel Catovsky, Martin John Swinnerton Dyer; Show fewer authors
Deletions and rearrangement of CDKN2 in lymphoid malignancy.
Blood 85:893-901(1995)

PubMed=8558920
Wilhelm Gerhard Dirks, Margarete Zaborski, Kathrin Jager, Cecile Challier, Mami Shiota, Hilmar Quentmeier, Hans Gunther Drexler;
The (2;5)(p23;q35) translocation in cell lines derived from malignant lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.
Leukemia 10:142-149(1996)

PubMed=9933131; DOI=10.1016/S0145-2126(98)00133-7
Renate Burger, Thomas E. Hansen-Hagge, Hans Gunther Drexler, Martin Gramatzki;
Heterogeneity of T-acute lymphoblastic leukemia (T-ALL) cell lines: suggestion for classification by immunophenotype and T-cell receptor studies.
Leuk. Res. 23:19-27(1999)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=11264379; DOI=10.1128/JVI.75.8.3903-3915.2001; PMCID=PMC114881
Robert E. Means, Thomas Matthews, James A. Hoxie, Michael Henry Malim, Toshiaki Kodama, Ronald Charles Desrosiers;
Ability of the V3 loop of simian immunodeficiency virus to serve as a target for antibody-mediated neutralization: correlation of neutralization sensitivity, growth in macrophages, and decreased dependence on CD4.
J. Virol. 75:3903-3915(2001)

PubMed=17170727; DOI=10.1038/sj.leu.2404486
Yorick Sandberg, Brenda Verhaaf, Ellen J. van Gastel-Mol, Ingrid L.M. Wolvers-Tettero, John De Vos, Roderick A.F. MacLeod, Jeroen G. Noordzij, Willem A. Dik, Jack J.M. van Dongen, Anton W. Langerak;
Human T-cell lines with well-defined T-cell receptor gene rearrangements as controls for the BIOMED-2 multiplex polymerase chain reaction tubes.
Leukemia 21:230-237(2007)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22292511; DOI=10.2174/187221512799303172
Ping Ho, Ken-Shwo Dai, Hui-Ling Chen;
Molecular cloning of a novel PPEF-1 gene variant from a T-cell lymphoblastic lymphoma cell line.
Recent Pat. DNA Gene Seq. 6:72-77(2012)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22675565; DOI=10.1371/journal.pone.0038463; PMCID=PMC3366948
Zeynep Kalender Atak, Kim De Keersmaecker, Valentina Gianfelici, Ellen Geerdens, Roel Vandepoel, Daphnie Pauwels, Michael Porcu, Idoya Lahortiga, Vanessa Brys, Wilhelm Gerhard Dirks, Hilmar Quentmeier ...Show all 17 authors... , Jacqueline Cloos, Harry Cuppens, Anne Uyttebroeck, Peter Vandenberghe, Jan Cools, Stein Aerts; Show fewer authors
High accuracy mutation detection in leukemia on a selected panel of cancer genes.
PLoS ONE 7:e38463.1-e38463.11(2012)

PubMed=25355872; DOI=10.1128/JVI.02570-14; PMCID=PMC4301145
Su-Bing Cao, Michael J. Strong, Xia Wang, Walter N. Moss, Monica Concha, Zhen Lin, Tina O'Grady, Melody Baddoo, Claire Fewell, Rolf Renne, Erik K. Flemington;
High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.
J. Virol. 89:713-729(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=29304865; DOI=10.1186/s12985-017-0917-z; PMCID=PMC5755443
Aniuska Becerra-Artiles, Tessa Santoro, Lawrence J. Stern;
Evaluation of a method to measure HHV-6B infection in vitro based on cell size.
Virol. J. 15:4.1-4.15(2018)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786
Kar-Tong Tan, Ling-Wen Ding, Qiao-Yang Sun, Zhen-Tang Lao, Wenwen Chien, Xi Ren, Jin-Fen Xiao, Xin-Yi Loh, Liang Xu, Michael Lill, Anand Mayakonda ...Show all 14 authors... , De-Chen Lin, Henry He Yang, Harold Phillip Koeffler; Show fewer authors
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940.1-940.13(2018)

PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144
Cord C. Uphoff, Claudia Pommerenke, Sabine A. Denkmann, Hans Gunther Drexler;
Screening human cell lines for viral infections applying RNA-Seq data analysis.
PLoS ONE 14:e0210404.1-e0210404.22(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=32938764; DOI=10.1128/JVI.01334-20; PMCID=PMC7654282
Melissa Victoria Fernandez, Huxley K. Hoffman, Nairi Pezeshkian, Philip R. Tedbury, Schuyler B. van Engelenburg, Eric O. Freed;
Elucidating the basis for permissivity of the MT-4 T-cell line to replication of an HIV-1 mutant lacking the gp41 cytoplasmic tail.
J. Virol. 94:e01334.20.1-e01334.20.27(2020)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ATCC; CRL-1942
BCRC; 60191
BEI_Resources; ARP-100
BEI_Resources; ARP-150
DSMZ; ACC-140
ECACC; 95013123
ICLC; HTL96007
Cell line databases/resources CLO; CLO_0009164
CLDB; cl4420
CLDB; cl4421
CLDB; cl4422
cancercelllines; CVCL_1714
Cell_Model_Passport; SIDM01154
Cosmic-CLP; 909743
DepMap; ACH-000953
DSMZCellDive; ACC-140
LINCS_LDP; LCL-1023
Lonza; 293
Anatomy/cell type resources BTO; BTO_0003582
Biological sample resources BioSample; SAMN03471266
BioSample; SAMN03473416
BioSample; SAMN10987655
CRISP screens repositories BioGRID_ORCS_Cell_line; 456
Chemistry resources ChEMBL-Cells; CHEMBL3308368
ChEMBL-Targets; CHEMBL614940
GDSC; 909743
PharmacoDB; SUPT1_1522_2019
PubChem_Cell_line; CVCL_1714
Encyclopedic resources Wikidata; Q54970880
Experimental variables resources EFO; EFO_0022582
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM482493
GEO; GSM887662
GEO; GSM888754
GEO; GSM1670494
Polymorphism and mutation databases Cosmic; 687855
Cosmic; 909743
Cosmic; 1086322
Cosmic; 1281384
Cosmic; 1330493
Cosmic; 1524822
Cosmic; 1664528
Cosmic; 1760532
Cosmic; 2165716
Cosmic; 2602931
LiGeA; CCLE_331
Progenetix; CVCL_1714
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number44