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Cellosaurus V-C8 (CVCL_X405)

[Text version]
Cell line name V-C8
Synonyms VC8
Accession CVCL_X405
Resource Identification Initiative To cite this cell line use: V-C8 (RRID:CVCL_X405)
Comments Transformant: ChEBI; CHEBI_23995; N-ethyl-N-nitrosourea (ENU).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Cell type: Fibroblast of lung; CL=CL_0002553.
Sequence variations
  • Mutation; UniProtKB; O09185; Tp53; Simple; p.Leu133Gln (c.398T>A); Zygosity=Unspecified (from parent cell line).
  • Mutation; UniProtKB; O09185; Tp53; Simple; p.Cys135Trp (c.405C>G); Zygosity=Unspecified (from parent cell line).
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_2234 (V79)
Sex of cell Male
Age at sampling Adult
Category Transformed cell line
Publications

PubMed=3587254; DOI=10.1016/0027-5107(87)90274-0
Malgorzata Zofia Zdzienicka, Johannes W.I.M. Simons;
Mutagen-sensitive cell lines are obtained with a high frequency in V79 Chinese hamster cells.
Mutat. Res. 178:235-244(1987)

PubMed=7565860; DOI=10.1016/0921-8777(95)00017-E
Gerald W.C.T. Verhaegh, Wim Jongmans, Bruno Morolli, Nicolaas G.J. Jaspers, Govert Paulus van der Schans, Paul H.M. Lohman, Malgorzata Zofia Zdzienicka;
A novel type of X-ray-sensitive Chinese hamster cell mutant with radioresistant DNA synthesis and hampered DNA double-strand break repair.
Mutat. Res. 337:119-129(1995)

PubMed=11756561; DOI=10.1128/mcb.22.2.669-679.2002; PMCID=PMC139737
Maria Kraakman-van der Zwet, Wilhelmina J.I. Overkamp, Rebecca E.E. van Lange, Jeroen Essers, Annemarie van Duijn-Goedhart, Ingrid Wiggers, Srividya Swaminathan, Paul P.W. van Buul, Abdellatif Errami, Raoul T.L. Tan, Nicolaas G.J. Jaspers ...Show all 14 authors... , Shyam K. Sharan, Roland Kanaar, Malgorzata Zofia Zdzienicka; Show fewer authors
Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions.
Mol. Cell. Biol. 22:669-679(2002)

PubMed=16643964; DOI=10.1016/j.mrfmmm.2006.03.001
Wouter W. Wiegant, Rene M. Overmeer, Barbara C. Godthelp, Paul P.W. van Buul, Malgorzata Zofia Zdzienicka;
Chinese hamster cell mutant, V-C8, a model for analysis of Brca2 function.
Mutat. Res. 600:79-88(2006)

Cross-references
Encyclopedic resources Wikidata; Q54992453
Entry history
Entry creation17-Jul-2014
Last entry update19-Dec-2024
Version number13