ID   V-C8
AC   CVCL_X405
SY   VC8
DR   Wikidata; Q54992453
RX   PubMed=3587254;
RX   PubMed=7565860;
RX   PubMed=11756561;
RX   PubMed=16643964;
CC   Sequence variation: Mutation; UniProtKB; O09185; Tp53; Simple; p.Leu133Gln (c.398T>A); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; UniProtKB; O09185; Tp53; Simple; p.Cys135Trp (c.405C>G); Zygosity=Unspecified (from parent cell line).
CC   Transformant: ChEBI; CHEBI:23995; N-ethyl-N-nitrosourea (ENU).
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
CC   Cell type: Fibroblast of lung; CL=CL_0002553.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_2234 ! V79
SX   Male
AG   Adult
CA   Transformed cell line
DT   Created: 17-07-14; Last updated: 29-06-23; Version: 12
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RX   PubMed=3587254; DOI=10.1016/0027-5107(87)90274-0;
RA   Zdzienicka M.Z., Simons J.W.I.M.;
RT   "Mutagen-sensitive cell lines are obtained with a high frequency in
RT   V79 Chinese hamster cells.";
RL   Mutat. Res. 178:235-244(1987).
//
RX   PubMed=7565860; DOI=10.1016/0921-8777(95)00017-E;
RA   Verhaegh G.W.C.T., Jongmans W., Morolli B., Jaspers N.G.J.,
RA   van der Schans G.P., Lohman P.H.M., Zdzienicka M.Z.;
RT   "A novel type of X-ray-sensitive Chinese hamster cell mutant with
RT   radioresistant DNA synthesis and hampered DNA double-strand break
RT   repair.";
RL   Mutat. Res. 337:119-129(1995).
//
RX   PubMed=11756561; DOI=10.1128/mcb.22.2.669-679.2002;
RA   Kraakman-van der Zwet M., Overkamp W.J.I., van Lange R.E.E.,
RA   Essers J., van Duijn-Goedhart A., Wiggers I., Swaminathan S.,
RA   van Buul P.P.W., Errami A., Tan R.T.L., Jaspers N.G.J., Sharan S.K.,
RA   Kanaar R., Zdzienicka M.Z.;
RT   "Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and
RT   a higher frequency of spontaneous deletions.";
RL   Mol. Cell. Biol. 22:669-679(2002).
//
RX   PubMed=16643964; DOI=10.1016/j.mrfmmm.2006.03.001;
RA   Wiegant W.W., Overmeer R.M., Godthelp B.C., van Buul P.P.W.,
RA   Zdzienicka M.Z.;
RT   "Chinese hamster cell mutant, V-C8, a model for analysis of Brca2
RT   function.";
RL   Mutat. Res. 600:79-88(2006).
//