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Cellosaurus SKF5 (CVCL_WY49)

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Cell line name SKF5
Synonyms SKF-5
Accession CVCL_WY49
Resource Identification Initiative To cite this cell line use: SKF5 (RRID:CVCL_WY49)
Comments Problematic cell line: Misclassified. Parent cell line (SK-N-MC) was originally thought to be a neuroblastoma cell line but shown to be from an Askin tumor.
Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:3236; EGFR (Note=With p.Leu682_Ala1210del; HERRet fusion).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:9967; RET (Note=With p.Met1_Lys662del; HERRet fusion).
Derived from site: Metastatic; Orbital region; UBERON=UBERON_0004088.
Sequence variations
  • Gene fusion; HGNC; HGNC:3508; EWSR1 + HGNC; HGNC:3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1; Note=Type 1 fusion (Ex7/Ex6) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.170_572del; Zygosity=Unspecified (from parent cell line).
Disease Askin tumor (NCIt: C7542)
Peripheral primitive neuroectodermal tumor (ORDO: Orphanet_370348)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0530 (SK-N-MC)
Sex of cell Female
Age at sampling 12Y
Category Cancer cell line
Publications

PubMed=8570170
David H.J. van Weering, Jan Paul Medema, Andre A.F.L. van Puijenbroek, Boudewijn M.T. Burgering, Pieter D. Baas, Johannes Lukas Bos;
Ret receptor tyrosine kinase activates extracellular signal-regulated kinase 2 in SK-N-MC cells.
Oncogene 11:2207-2214(1995)

PubMed=9121763; DOI=10.1038/sj.onc.1200911
Andre A.F.L. van Puijenbroek, David H.J. van Weering, Christina E. van den Brink, Johannes Lukas Bos, Paul T. van der Saag, Siegfried Wolfgang de Laat, Jeroen den Hertog;
Cell scattering of SK-N-MC neuroepithelioma cells in response to Ret and FGF receptor tyrosine kinase activation is correlated with sustained ERK2 activation.
Oncogene 14:1147-1157(1997)

Cross-references
Encyclopedic resources Wikidata; Q98132678
Entry history
Entry creation06-Sep-2019
Last entry update19-Dec-2024
Version number12