ID   SKF5
AC   CVCL_WY49
SY   SKF-5
DR   Wikidata; Q98132678
RX   PubMed=8570170;
RX   PubMed=9121763;
CC   Problematic cell line: Misclassified. Parent cell line (SK-N-MC) was originally thought to be a neuroblastoma cell line but shown to be from an Askin tumor.
CC   Population: Caucasian.
CC   Sequence variation: Gene fusion; HGNC; HGNC:3508; EWSR1 + HGNC; HGNC:3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1; Note=Type 1 fusion (Ex7/Ex6) (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; c.170_572del; Zygosity=Unspecified (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:3236; EGFR (Note=With p.Leu682_Ala1210del; HERRet fusion).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:9967; RET (Note=With p.Met1_Lys662del; HERRet fusion).
CC   Derived from site: Metastatic; Orbital region; UBERON=UBERON_0004088.
DI   NCIt; C7542; Askin tumor
DI   ORDO; Orphanet_370348; Peripheral primitive neuroectodermal tumor
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0530 ! SK-N-MC
SX   Female
AG   12Y
CA   Cancer cell line
DT   Created: 06-09-19; Last updated: 19-12-24; Version: 12
//
RX   PubMed=9121763; DOI=10.1038/sj.onc.1200911;
RA   van Puijenbroek, Andre A.F.L.
RA   van Weering, David H.J.
RA   van den Brink, Christina E.
RA   Bos, Johannes Lukas
RA   van der Saag, Paul T.
RA   de Laat, Siegfried Wolfgang
RA   den Hertog, Jeroen
RT   "Cell scattering of SK-N-MC neuroepithelioma cells in response to Ret
RT   and FGF receptor tyrosine kinase activation is correlated with
RT   sustained ERK2 activation.";
RL   Oncogene 14:1147-1157(1997).
//
RX   PubMed=8570170;
RA   van Weering, David H.J.
RA   Medema, Jan Paul
RA   van Puijenbroek, Andre A.F.L.
RA   Burgering, Boudewijn M.T.
RA   Baas, Pieter D.
RA   Bos, Johannes Lukas
RT   "Ret receptor tyrosine kinase activates extracellular signal-regulated
RT   kinase 2 in SK-N-MC cells.";
RL   Oncogene 11:2207-2214(1995).
//