ID   SKF5
AC   CVCL_WY49
SY   SKF-5
DR   Wikidata; Q98132678
RX   PubMed=8570170;
RX   PubMed=9121763;
CC   Problematic cell line: Misclassified. Parent cell line (SK-N-MC) was originally thought to be a neuroblastoma cell line but shown to be from an Askin tumor.
CC   Population: Caucasian.
CC   Sequence variation: Gene fusion; HGNC; HGNC:3508; EWSR1 + HGNC; HGNC:3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1; Note=Type 1 fusion (Ex7/Ex6) (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; c.170_572del; Zygosity=Unspecified (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:3236; EGFR (Note=With p.Leu682_Ala1210del; HERRet fusion).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:9967; RET (Note=With p.Met1_Lys662del; HERRet fusion).
CC   Derived from site: Metastatic; Orbital region; UBERON=UBERON_0004088.
DI   NCIt; C7542; Askin tumor
DI   ORDO; Orphanet_370348; Peripheral primitive neuroectodermal tumor
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0530 ! SK-N-MC
SX   Female
AG   12Y
CA   Cancer cell line
DT   Created: 06-09-19; Last updated: 19-12-24; Version: 12
//
RX   PubMed=8570170;
RA   van Weering D.H.J., Medema J.P., van Puijenbroek A.A.F.L.,
RA   Burgering B.M.T., Baas P.D., Bos J.L.;
RT   "Ret receptor tyrosine kinase activates extracellular signal-regulated
RT   kinase 2 in SK-N-MC cells.";
RL   Oncogene 11:2207-2214(1995).
//
RX   PubMed=9121763; DOI=10.1038/sj.onc.1200911;
RA   van Puijenbroek A.A.F.L., van Weering D.H.J., van den Brink C.E.,
RA   Bos J.L., van der Saag P.T., de Laat S.W., den Hertog J.;
RT   "Cell scattering of SK-N-MC neuroepithelioma cells in response to Ret
RT   and FGF receptor tyrosine kinase activation is correlated with
RT   sustained ERK2 activation.";
RL   Oncogene 14:1147-1157(1997).
//