• Mutation; RGD; 3908; Tsc2; Simple; p.Val1272fs; Zygosity=Heterozygous; Note=Insertion of a 5 kb retrotransposon (PubMed=7704028).
  

PubMed=7559744; DOI=10.1007/BF01197777
Okio Hino, Eisuko Kobayashi, Masae Nishizawa, Yoshihiro Kubo, Toshiyuki Kobayashi, Youko Hirayama, Shunsuke Takai, Yasushi Kikuchi, Haruo Tsuchiya, Kenji Orimoto, Kazunori Kajino, Terumi Takahara;
Renal carcinogenesis in the Eker rat.
J. Cancer Res. Clin. Oncol. 121:602-605(1995)

PubMed=7704028; DOI=10.1038/ng0195-70
Toshiyuki Kobayashi, Youko Hirayama, Etsuko Kobayashi, Yoshihiro Kubo, Okio Hino;
A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer.
Nat. Genet. 9:70-74(1995)

PubMed=11011112; DOI=10.1111/j.1349-7006.2000.tb01027.x; PMCID=PMC5926447
Shuichi Majima, Kazunori Kajino, Tomokazu Fukuda, Fujio Otsuka, Okio Hino;
A novel gene 'Niban' upregulated in renal carcinogenesis: cloning by the cDNA-amplified fragment length polymorphism approach.
Jpn. J. Cancer Res. 91:869-874(2000)

PubMed=11115552; DOI=10.3892/ijo.18.1.147
Toshihiro Okamoto, Shuji Momose, Okio Hino;
Suppression of cytochrome P450 1A1 and 4A1 gene expression in renal carcinomas of TSC2 gene mutant (Eker) rats.
Int. J. Oncol. 18:147-149(2001)