| Cell line name |
Lk9dR |
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| Synonyms |
LK9d(R); Lk9D; LK9D; LK9d; lk9d |
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| Accession |
CVCL_WX08 |
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| Resource Identification Initiative |
To cite this cell line use: Lk9dR (RRID:CVCL_WX08) |
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| Comments |
Derived from site: In situ; Kidney; UBERON=UBERON_0002113. |
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| Sequence variations |
- Mutation; RGD; 3908; Tsc2; Simple; p.Val1272fs; Zygosity=Heterozygous; Note=Insertion of a 5 kb retrotransposon (PubMed=7704028).
|
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| Disease |
Carcinoma of the rat kidney (NCIt: C64111) |
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| Species of origin |
Rattus norvegicus (Rat)
(NCBI Taxonomy: 10116)
Breed/subspecies: Eker x Long-Evans; RS=RS_0000385+RS_0000347. |
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| Originate from same individual |
CVCL_WX07 ! Lk9dL |
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| Category |
Cancer cell line |
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| Publications | PubMed=7559744; DOI=10.1007/BF01197777
Hino O., Kobayashi E., Nishizawa M., Kubo Y., Kobayashi T., Hirayama Y., Takai S., Kikuchi Y., Tsuchiya H., Orimoto K., Kajino K., Takahara T.
Renal carcinogenesis in the Eker rat.
J. Cancer Res. Clin. Oncol. 121:602-605(1995) PubMed=7704028; DOI=10.1038/ng0195-70
Kobayashi T., Hirayama Y., Kobayashi E., Kubo Y., Hino O.
A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer.
Nat. Genet. 9:70-74(1995) PubMed=11011112; DOI=10.1111/j.1349-7006.2000.tb01027.x; PMCID=PMC5926447
Majima S., Kajino K., Fukuda T., Otsuka F., Hino O.
A novel gene 'Niban' upregulated in renal carcinogenesis: cloning by the cDNA-amplified fragment length polymorphism approach.
Jpn. J. Cancer Res. 91:869-874(2000) PubMed=11115552; DOI=10.3892/ijo.18.1.147
Okamoto T., Momose S., Hino O.
Suppression of cytochrome P450 1A1 and 4A1 gene expression in renal carcinomas of TSC2 gene mutant (Eker) rats.
Int. J. Oncol. 18:147-149(2001) |
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| Cross-references |
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| Encyclopedic resources |
Wikidata; Q95982403
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| Entry history |
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| Entry creation | 06-Sep-2019 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 7 |
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