ID   Lk9dR
AC   CVCL_WX08
SY   LK9d(R); Lk9D; LK9D; LK9d; lk9d
DR   Wikidata; Q95982403
RX   PubMed=7559744;
RX   PubMed=7704028;
RX   PubMed=11011112;
RX   PubMed=11115552;
CC   Sequence variation: Mutation; RGD; 3908; Tsc2; Simple; p.Val1272fs; Zygosity=Heterozygous; Note=Insertion of a 5 kb retrotransposon (PubMed=7704028).
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
CC   Breed/subspecies: Eker x Long-Evans; RS=RS_0000385+RS_0000347.
DI   NCIt; C64111; Carcinoma of the rat kidney
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
OI   CVCL_WX07 ! Lk9dL
CA   Cancer cell line
DT   Created: 06-09-19; Last updated: 10-04-25; Version: 7
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RX   PubMed=7559744; DOI=10.1007/BF01197777;
RA   Hino O., Kobayashi E., Nishizawa M., Kubo Y., Kobayashi T.,
RA   Hirayama Y., Takai S., Kikuchi Y., Tsuchiya H., Orimoto K.,
RA   Kajino K., Takahara T.;
RT   "Renal carcinogenesis in the Eker rat.";
RL   J. Cancer Res. Clin. Oncol. 121:602-605(1995).
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RX   PubMed=7704028; DOI=10.1038/ng0195-70;
RA   Kobayashi T., Hirayama Y., Kobayashi E., Kubo Y., Hino O.;
RT   "A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise
RT   to the Eker rat model of dominantly inherited cancer.";
RL   Nat. Genet. 9:70-74(1995).
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RX   PubMed=11011112; DOI=10.1111/j.1349-7006.2000.tb01027.x; PMCID=PMC5926447;
RA   Majima S., Kajino K., Fukuda T., Otsuka F., Hino O.;
RT   "A novel gene 'Niban' upregulated in renal carcinogenesis: cloning by
RT   the cDNA-amplified fragment length polymorphism approach.";
RL   Jpn. J. Cancer Res. 91:869-874(2000).
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RX   PubMed=11115552; DOI=10.3892/ijo.18.1.147;
RA   Okamoto T., Momose S., Hino O.;
RT   "Suppression of cytochrome P450 1A1 and 4A1 gene expression in renal
RT   carcinomas of TSC2 gene mutant (Eker) rats.";
RL   Int. J. Oncol. 18:147-149(2001).
//