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Cellosaurus LN-229_indWIF1 (CVCL_WS33)

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Cell line name LN-229_indWIF1
Accession CVCL_WS33
Resource Identification Initiative To cite this cell line use: LN-229_indWIF1 (RRID:CVCL_WS33)
Comments Population: Caucasian.
Characteristics: Dox-induced expression (using rtTA) of WIF1 and dsRED.
Genetic integration: Method=Transfection/transduction; Gene=FPbase; EGE3L; DsRed (Note=drFP583, red fluorescent protein from Discosoma sp.).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:18081; WIF1.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: In situ; Brain, right frontal parieto-occipital cortex.
Sequence variations
  • Mutation; HGNC; HGNC:6597; LIFR; Simple; p.Pro1060Ala (c.3178C>G); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9811; RAD21; Simple; p.Gln132Ter (c.394C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro98Leu (c.293C>T); ClinVar=VCV000528236; Zygosity=Homozygous (from parent cell line).
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0393 (LN-229)
Sex of cell Female
Age at sampling 60Y
Category Cancer cell line
Publications

PubMed=25772239; DOI=10.1038/onc.2015.61
Irene Vassallo, Pascal O. Zinn, Marta Lai, Premnath Rajakannu, Marie-France Hamou, Monika E. Hegi;
WIF1 re-expression in glioblastoma inhibits migration through attenuation of non-canonical WNT signaling by downregulating the lncRNA MALAT1.
Oncogene 35:12-21(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_WS33
Encyclopedic resources Wikidata; Q95982661
Entry history
Entry creation05-Jul-2019
Last entry update14-Aug-2025
Version number13