ID   LN-229_indWIF1
AC   CVCL_WS33
DR   cancercelllines; CVCL_WS33
DR   Wikidata; Q95982661
RX   PubMed=25772239;
CC   Population: Caucasian.
CC   Characteristics: Dox-induced expression (using rtTA) of WIF1 and dsRED.
CC   Sequence variation: Mutation; HGNC; 6597; LIFR; Simple; p.Pro1060Ala (c.3178C>G); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9811; RAD21; Simple; p.Gln132Ter (c.394C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Pro98Leu (c.293C>T); ClinVar=VCV000528236; Zygosity=Homozygous (from parent cell line).
CC   Transfected with: HGNC; 18081; WIF1.
CC   Transfected with: UniProtKB; Q9U6Y8; Discosoma sp. red fluorescent protein drFP583 (DsRed, RFP).
CC   Transfected with: UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Derived from site: In situ; Brain, right frontal parieto-occipital cortex.
DI   NCIt; C3058; Glioblastoma
DI   ORDO; Orphanet_360; Glioblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0393 ! LN-229
SX   Female
AG   60Y
CA   Cancer cell line
DT   Created: 05-07-19; Last updated: 05-10-23; Version: 9
//
RX   PubMed=25772239; DOI=10.1038/onc.2015.61;
RA   Vassallo I., Zinn P.O., Lai M., Rajakannu P., Hamou M.-F., Hegi M.E.;
RT   "WIF1 re-expression in glioblastoma inhibits migration through
RT   attenuation of non-canonical WNT signaling by downregulating the
RT   lncRNA MALAT1.";
RL   Oncogene 35:12-21(2016).
//