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Cellosaurus LN-2669GS_WIF1 (CVCL_WS32)

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Cell line name LN-2669GS_WIF1
Accession CVCL_WS32
Resource Identification Initiative To cite this cell line use: LN-2669GS_WIF1 (RRID:CVCL_WS32)
Comments Characteristics: Glioma-derived sphere line. Tumorigenic in nude mice (from parent cell line).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:18081; WIF1.
Derived from site: In situ; Brain, right frontal lobe; UBERON=UBERON_0002810.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Asp323Valfs*19; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (from parent cell line).
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_WS29 (LN-2669GS)
Sex of cell Male
Age at sampling 70Y
Category Cancer cell line
Publications

PubMed=25772239; DOI=10.1038/onc.2015.61
Irene Vassallo, Pascal O. Zinn, Marta Lai, Premnath Rajakannu, Marie-France Hamou, Monika E. Hegi;
WIF1 re-expression in glioblastoma inhibits migration through attenuation of non-canonical WNT signaling by downregulating the lncRNA MALAT1.
Oncogene 35:12-21(2016)

Cross-references
Encyclopedic resources Wikidata; Q95982665
Entry history
Entry creation05-Jul-2019
Last entry update19-Dec-2024
Version number10