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Cellosaurus LN-2669GS (CVCL_WS29)

[Text version]
Cell line name LN-2669GS
Accession CVCL_WS29
Resource Identification Initiative To cite this cell line use: LN-2669GS (RRID:CVCL_WS29)
Comments Characteristics: Glioma-derived sphere line. Tumorigenic in nude mice.
Omics: Array-based CGH.
Omics: DNA methylation analysis.
Omics: Transcriptome analysis by microarray.
Miscellaneous: STR profile from personal communication of Gusyatiner O.
Derived from site: In situ; Brain, right frontal lobe; UBERON=UBERON_0002810.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=22570425).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Asn323Valfs*19; Zygosity=Homozygous (PubMed=22570425).
  • Mutation; HGNC; 11998; TP53; None_reported; -; Zygosity=- (PubMed=22570425).
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_WS32 (LN-2669GS_WIF1)
Originate from same individual CVCL_S443 ! LN-2669
Sex of cell Male
Age at sampling 70Y
Category Cancer cell line
STR profile Source(s): Direct_author_submission

Markers:
AmelogeninX,Y
CSF1PO11,13
D1S165613,15
D2S44110,15
D2S133816,17
D3S135814,16
D5S81811,12
D7S8208,9
D8S117911,13
D10S124817
D12S39119,21
D13S31711,12
D16S53910,13
D18S5116
D19S43315.2,16
D21S1130,31.2
D22S104516
DYS39111
DYS57018
DYS57619
FGA24
Penta D13
Penta E12
SE3321.2,27.2
TH018,9.3
TPOX8,11
vWA15,17

Run an STR similarity search on this cell line
Publications

PubMed=21097691; DOI=10.1158/1078-0432.CCR-10-1931
Sciuscio D., Diserens A.-C., van Dommelen K., Martinet D., Jones G., Janzer R.-C., Pollo C., Hamou M.-F., Kaina B., Stupp R., Levivier M., Hegi M.E.
Extent and patterns of MGMT promoter methylation in glioblastoma- and respective glioblastoma-derived spheres.
Clin. Cancer Res. 17:255-266(2011)

PubMed=22570425; DOI=10.1093/neuonc/nos072
Bady P., Diserens A.-C., Castella V., Kalt S., Heinimann K., Hamou M.-F., Delorenzi M., Hegi M.E.
DNA fingerprinting of glioma cell lines and considerations on similarity measurements.
Neuro-oncol. 14:701-711(2012)

PubMed=25622821; DOI=10.1186/s13059-015-0583-7
Kurscheid S., Bady P., Sciuscio D., Samarzija I., Shay T., Vassallo I., Van Criekinge W., Daniel R.T., van den Bent M.J., Marosi C., Weller M., Mason W.P., Domany E., Stupp R., Delorenzi M., Hegi M.E.
Chromosome 7 gain and DNA hypermethylation at the HOXA10 locus are associated with expression of a stem cell related HOX-signature in glioblastoma.
Genome Biol. 16:16.1-16.15(2015)

PubMed=25772239; DOI=10.1038/onc.2015.61
Vassallo I., Zinn P.O., Lai M., Rajakannu P., Hamou M.-F., Hegi M.E.
WIF1 re-expression in glioblastoma inhibits migration through attenuation of non-canonical WNT signaling by downregulating the lncRNA MALAT1.
Oncogene 35:12-21(2016)

PubMed=27717037; DOI=10.1002/nbm.3610
Porcari P., Hegi M.E., Lei H.-X., Hamou M.-F., Vassallo I., Capuani S., Gruetter R., Mlynarik V.
Early detection of human glioma sphere xenografts in mouse brain using diffusion MRI at 14.1 T.
NMR Biomed. 29:1577-1589(2016)

Cross-references
Encyclopedic resources Wikidata; Q95982664
Gene expression databases GEO; GSM1469040
GEO; GSM2794464
GEO; GSM2794465
GEO; GSM2794466
GEO; GSM2889490
Entry history
Entry creation05-Jul-2019
Last entry update29-Jun-2023
Version number7