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Cellosaurus SUSM-1/RAS (CVCL_WH84)

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Cell line name SUSM-1/RAS
Accession CVCL_WH84
Resource Identification Initiative To cite this cell line use: SUSM-1/RAS (RRID:CVCL_WH84)
Comments Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gln61Leu).
Transformant: ChEBI; CHEBI_16907; 4-nitroquinoline N-oxide (4NQO).
Derived from site: In situ; Fetal liver; UBERON=UBERON_0002107.
Cell type: Fibroblast; CL=CL_0000057.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.His179Asn (c.535C>A); ClinVar=VCV000376609; Zygosity=Heterozygous (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4903 (SUSM-1)
Sex of cell Male
Age at sampling Fetus
Category Transformed cell line
Publications

DOI=10.11418/jtca1981.12.4_313
Masayoshi Namba, Li-Yan Bai, Yoshio Kano, Shigetaka Sugihara, Masahiro Miyazaki;
Multistep malignant transformation of human cells: immortalization of human fibroblasts by treatment with 60Co gamma rays and 4-nitroquinoline 1-oxide, and their malignant transformation with the ras oncogene.
Tissue Cult. Res. Commun. 12:313-318(1993)

PubMed=8148305
Masayoshi Namba, Mikio Iijima, Tadashi Kondo, Israt Jahan, Koichiro Mihara;
Immortalization of normal human cells is a multistep process and a rate limiting step of neoplastic transformation of the cells.
Hum. Cell 6:253-259(1993)

Cross-references
Encyclopedic resources Wikidata; Q98132882
Entry history
Entry creation24-May-2019
Last entry update19-Dec-2024
Version number10