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Cellosaurus SUSM-1 (CVCL_4903)

[Text version]

Cell line name SUSM-1
Synonyms SUSM1
Accession CVCL_4903
Resource Identification Initiative To cite this cell line use: SUSM-1 (RRID:CVCL_4903)
Comments Characteristics: Cell line positive for alternative lengthening of telomeres (ALT+) (CelloPub=CLPUB00712; PubMed=19935656).
Transformant: ChEBI; CHEBI:16907; 4-nitroquinoline N-oxide (4NQO).
Derived from sampling site: Fetal liver. Cell type=Fibroblast.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.His179Asn (c.535C>A); ClinVar=VCV000376609; Zygosity=Heterozygous (PubMed=8790940).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_M811 (HSF-412)
CVCL_VE91 (SUSM-1/p53-1)CVCL_VE92 (SUSM-1/p53-6)CVCL_WH84 (SUSM-1/RAS)
Sex of cell Male
Age at sampling Fetus
Category Transformed cell line
STR profile Source(s): RCB


Run an STR similarity search on this cell line

Namba M., Nishitani K., Fukushima F., Kimoto T.
Multistep carcinogenesis of normal human fibroblasts. Human fibroblasts immortalized by repeated treatment with Co-60 gamma rays were transformed into tumorigenic cells with Ha-ras oncogenes.
Anticancer Res. 8:947-958(1988)

PubMed=3413074; DOI=10.1073/pnas.85.16.6042
Pereira-Smith O.M., Smith J.R.
Genetic analysis of indefinite division in human cells: identification of four complementation groups.
Proc. Natl. Acad. Sci. U.S.A. 85:6042-6046(1988)

Namba M., Bai L., Kano Y., Sugihara S., Miyazaki M.
Multistep malignant transformation of human cells: immortalization of human fibroblasts by treatment with 60Co gamma rays and 4-nitroquinoline 1-oxide, and their malignant transformation with the ras oncogene.
Tissue Cult. Res. Commun. 12:313-318(1993)

PubMed=8105370; DOI=10.1128/mcb.13.10.6036-6043.1993
Ogata T., Ayusawa D., Namba M., Takahashi E., Oshimura M., Oishi M.
Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1.
Mol. Cell. Biol. 13:6036-6043(1993)

Namba M., Iijima M., Kondo T., Jahan I., Mihara K.
Immortalization of normal human cells is a multistep process and a rate limiting step of neoplastic transformation of the cells.
Hum. Cell 6:253-259(1993)

PubMed=7705936; DOI=10.1002/ijc.2910610113
Kawashima K., Mihara K., Usuki H., Shimizu N., Namba M.
Transfected mutant p53 gene increases X-ray-induced cell killing and mutation in human fibroblasts immortalized with 4-nitroquinoline 1-oxide but does not induce neoplastic transformation of the cells.
Int. J. Cancer 61:76-79(1995)

PubMed=8557247; DOI=10.1007/BF00218823
Sugihara S., Mihara K., Marunouchi T., Inoue H., Namba M.
Telomere elongation observed in immortalized human fibroblasts by treatment with 60Co gamma rays or 4-nitroquinoline 1-oxide.
Hum. Genet. 97:1-6(1996)

PubMed=8744932; DOI=10.18926/AMO/30489
Iijima M., Kano Y., Nohno T., Namba M.
Cloning of cDNA with possible transcription factor activity at the G1-S phase transition in human fibroblast cell lines.
Acta Med. Okayama 50:73-77(1996)

PubMed=8790940; DOI=10.1247/csf.21.111
Mihara K., Iijima M., Kondo T., Namba M.
Selective expression of mutated p53 in human cells immortalized with either 4-nitroquinoline 1-oxide or 60Co gamma rays.
Cell Struct. Funct. 21:111-116(1996)

Mihara K., Miyazaki M., Fushimi K., Tsuji T., Inoue Y., Fukaya K.-I., Ohashi R., Namba M.
The p53 gene status and other cellular characteristics of human cell lines maintained in our laboratory.
Tissue Cult. Res. Commun. 16:173-178(1997)

PubMed=9175740; DOI=10.1093/hmg/6.6.921
Bryan T.M., Marusic L., Bacchetti S., Namba M., Reddel R.R.
The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit.
Hum. Mol. Genet. 6:921-926(1997)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=9359923; DOI=10.18926/AMO/30789
Mihara K., Miyazaki M., Kondo T., Fushimi K., Tsuji T., Inoue Y., Fukaya K.-I., Ishioka C., Namba M.
Yeast functional assay of the p53 gene status in human cell lines maintained in our laboratory.
Acta Med. Okayama 51:261-265(1997)

Henson J.D.
The role of alternative lengthening of telomeres in human cancer.
Thesis PhD (2006), University of Sydney, Australia

PubMed=19935656; DOI=10.1038/nbt.1587
Henson J.D., Cao Y., Huschtscha L.I., Chang A.C., Au A.Y.M., Pickett H.A., Reddel R.R.
DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity.
Nat. Biotechnol. 27:1181-1185(2009)

Cell line collections RCB; RCB0174
Cell line databases/resources CLO; CLO_0050043
Biological sample resources BioSample; SAMN03472342
Encyclopedic resources Wikidata; Q54970920
Polymorphism and mutation databases IARC_TP53; 5360
Entry history
Entry creation04-Apr-2012
Last entry update22-Sep-2022
Version number19