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Cellosaurus SUSM-1 (CVCL_4903)

[Text version]
Cell line name SUSM-1
Synonyms SUSM1
Accession CVCL_4903
Resource Identification Initiative To cite this cell line use: SUSM-1 (RRID:CVCL_4903)
Comments Characteristics: Cell line positive for alternative lengthening of telomeres (ALT+) (CelloPub=CLPUB00712; PubMed=19935656).
Transformant: ChEBI; CHEBI_16907; 4-nitroquinoline N-oxide (4NQO).
Derived from site: In situ; Fetal liver; UBERON=UBERON_0002107.
Cell type: Fibroblast; CL=CL_0000057.
Sequence variations
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_M811 (HSF-412)
Children:
CVCL_VE91 (SUSM-1/p53-1)CVCL_VE92 (SUSM-1/p53-6)CVCL_WH84 (SUSM-1/RAS)
Sex of cell Male
Age at sampling Fetus
Category Transformed cell line
STR profile Source(s): RCB=RCB0174

Markers:
AmelogeninX,Y
CSF1PO10,11
D5S81812,13
D7S82010,11
D13S31711
D16S53912
TH018
TPOX8,11
vWA16,18

Run an STR similarity search on this cell line
Publications

PubMed=3140712
Masayoshi Namba, Koji Nishitani, Fujiko Fukushima, Tetsuo Kimoto;
Multistep carcinogenesis of normal human fibroblasts. Human fibroblasts immortalized by repeated treatment with Co-60 gamma rays were transformed into tumorigenic cells with Ha-ras oncogenes.
Anticancer Res. 8:947-958(1988)

PubMed=3413074; DOI=10.1073/pnas.85.16.6042; PMCID=PMC281901
Olivia M. Pereira-Smith, James R. Smith;
Genetic analysis of indefinite division in human cells: identification of four complementation groups.
Proc. Natl. Acad. Sci. U.S.A. 85:6042-6046(1988)

DOI=10.11418/jtca1981.12.4_313
Masayoshi Namba, Li-Yan Bai, Yoshio Kano, Shigetaka Sugihara, Masahiro Miyazaki;
Multistep malignant transformation of human cells: immortalization of human fibroblasts by treatment with 60Co gamma rays and 4-nitroquinoline 1-oxide, and their malignant transformation with the ras oncogene.
Tissue Cult. Res. Commun. 12:313-318(1993)

PubMed=8105370; DOI=10.1128/mcb.13.10.6036-6043.1993; PMCID=PMC364663
Toshihiko Ogata, Dai Ayusawa, Masayoshi Namba, Eiichi Takahashi, Mitsuo Oshimura, Michio Oishi;
Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1.
Mol. Cell. Biol. 13:6036-6043(1993)

PubMed=8148305
Masayoshi Namba, Mikio Iijima, Tadashi Kondo, Israt Jahan, Koichiro Mihara;
Immortalization of normal human cells is a multistep process and a rate limiting step of neoplastic transformation of the cells.
Hum. Cell 6:253-259(1993)

PubMed=7705936; DOI=10.1002/ijc.2910610113
Kunihiro Kawashima, Koichiro Mihara, Hisashi Usuki, Nobuyoshi Shimizu, Masayoshi Namba;
Transfected mutant p53 gene increases X-ray-induced cell killing and mutation in human fibroblasts immortalized with 4-nitroquinoline 1-oxide but does not induce neoplastic transformation of the cells.
Int. J. Cancer 61:76-79(1995)

PubMed=8557247; DOI=10.1007/BF00218823
Shinsuke Sugihara, Koichiro Mihara, Tohru Marunouchi, Hajime Inoue, Masayoshi Namba;
Telomere elongation observed in immortalized human fibroblasts by treatment with 60Co gamma rays or 4-nitroquinoline 1-oxide.
Hum. Genet. 97:1-6(1996)

PubMed=8744932; DOI=10.18926/AMO/30489
Mikio Iijima, Yoshio Kano, Tsutomu Nohno, Masayoshi Namba;
Cloning of cDNA with possible transcription factor activity at the G1-S phase transition in human fibroblast cell lines.
Acta Med. Okayama 50:73-77(1996)

PubMed=8790940; DOI=10.1247/csf.21.111
Koichiro Mihara, Mikio Iijima, Tadashi Kondo, Masayoshi Namba;
Selective expression of mutated p53 in human cells immortalized with either 4-nitroquinoline 1-oxide or 60Co gamma rays.
Cell Struct. Funct. 21:111-116(1996)

DOI=10.11418/jtca1981.16.3_173
Koichiro Mihara, Masahiro Miyazaki, Kazuo Fushimi, Toshiya Tsuji, Yusuke Inoue, Ken-ichi Fukaya, Ryuichiro Ohashi, Masayoshi Namba;
The p53 gene status and other cellular characteristics of human cell lines maintained in our laboratory.
Tissue Cult. Res. Commun. 16:173-178(1997)

PubMed=9175740; DOI=10.1093/hmg/6.6.921
Tracy M. Bryan, Lidija Marusic, Silvia Bacchetti, Masayoshi Namba, Roger Robert Reddel;
The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit.
Hum. Mol. Genet. 6:921-926(1997)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Li-Qun Jia, Motonobu Osada, Chikashi Ishioka, Makio Gamo, Shuntaro Ikawa, Takao Suzuki, Hideki Shimodaira, Tomohito Niitani, Toshio Kudo, Mitoshi Akiyama, Narimiti Kimura ...Show all 18 authors... , Mitsuyoshi Matsuo, Hiroshi Mizusawa, Noriho Tanaka, Hideki Koyama, Masayoshi Namba, Ryunosuke Kanamaru, Toshio Kuroki; Show fewer authors
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=9359923; DOI=10.18926/AMO/30789
Koichiro Mihara, Masahiro Miyazaki, Tadashi Kondo, Kazuo Fushimi, Toshiya Tsuji, Yusuke Inoue, Ken-ichi Fukaya, Chikashi Ishioka, Masayoshi Namba;
Yeast functional assay of the p53 gene status in human cell lines maintained in our laboratory.
Acta Med. Okayama 51:261-265(1997)

CLPUB00712
Jeremy David Henson;
The role of alternative lengthening of telomeres in human cancer.
Thesis PhD (2006); University of Sydney; Sydney; Australia

PubMed=19935656; DOI=10.1038/nbt.1587
Jeremy David Henson, Ying Cao, Lily I. Huschtscha, Andy C.-M. Chang, Amy Y.M. Au, Hilda A. Pickett, Roger Robert Reddel;
DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity.
Nat. Biotechnol. 27:1181-1185(2009)

Cross-references
Cell line collections (Providers) RCB; RCB0174
Cell line databases/resources CLO; CLO_0050043
Biological sample resources BioSample; SAMN03472342
Encyclopedic resources Wikidata; Q54970920
Polymorphism and mutation databases IARC_TP53; 5360
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number23