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Cellosaurus SUSM-1/p53-6 (CVCL_VE92)

[Text version]
Cell line name SUSM-1/p53-6
Synonyms SUSM-1/P53-6
Accession CVCL_VE92
Resource Identification Initiative To cite this cell line use: SUSM-1/p53-6 (RRID:CVCL_VE92)
Comments Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:11998; TP53 (Note=With p.Arg273His).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Transformant: ChEBI; CHEBI_16907; 4-nitroquinoline N-oxide (4NQO).
Derived from site: In situ; Fetal liver; UBERON=UBERON_0002107.
Cell type: Fibroblast; CL=CL_0000057.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.His179Asn (c.535C>A); ClinVar=VCV000376609; Zygosity=Heterozygous (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4903 (SUSM-1)
Sex of cell Male
Age at sampling Fetus
Category Transformed cell line
Publications

PubMed=7705936; DOI=10.1002/ijc.2910610113
Kunihiro Kawashima, Koichiro Mihara, Hisashi Usuki, Nobuyoshi Shimizu, Masayoshi Namba;
Transfected mutant p53 gene increases X-ray-induced cell killing and mutation in human fibroblasts immortalized with 4-nitroquinoline 1-oxide but does not induce neoplastic transformation of the cells.
Int. J. Cancer 61:76-79(1995)

Cross-references
Encyclopedic resources Wikidata; Q54970922
Entry history
Entry creation14-May-2018
Last entry update14-Aug-2025
Version number13