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Cellosaurus N (CVCL_UZ57)

[Text version]
Cell line name N
Synonyms Strain N
Accession CVCL_UZ57
Resource Identification Initiative To cite this cell line use: N (RRID:CVCL_UZ57)
Comments Senescence: Senesces at ~52-55 PDL (PubMed=10648628; PubMed=12077343).
Derived from site: In situ; Skin, epidermis; UBERON=UBERON_0001003.
Cell type: Keratinocyte; CL=CL_0000312.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_UZ60 (N/bmi1/TERT)CVCL_UZ61 (N/E6E7)CVCL_CW92 (N/TERT-1)
CVCL_UZ62 (N/TERT-2)
Sex of cell Male
Age at sampling <1M
Category Finite cell line
Web pages Provider; BWH dermatology; -; https://dermatology.bwh.harvard.edu/docs/Cell-Culture-Core-Cell-Lines.pdf
Publications

PubMed=10648628; DOI=10.1128/mcb.20.4.1436-1447.2000; PMCID=PMC85304
Mark A. Dickson, William Chun Hahn, Yasushi Ino, Vincent Ronfard, Jenny Y. Wu, Robert Allan Weinberg, David Neil Louis, Frederick Pei Li, James George Rheinwald;
Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics.
Mol. Cell. Biol. 20:1436-1447(2000)

PubMed=12077343; DOI=10.1128/mcb.22.14.5157-5172.2002; PMCID=PMC139780
James George Rheinwald, William Chun Hahn, Matthew Robert Ramsey, Jenny Y. Wu, Zong-You Guo, Hensin Tsao, Michele De Luca, Caterina Catricala, Kathleen M. O'Toole;
A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status.
Mol. Cell. Biol. 22:5157-5172(2002)

PubMed=19489101; DOI=10.1002/stem.64; PMCID=PMC2733375
Sally Dabelsteen, Paula Hercule, Patricia Barron, Meghan Rice, Gregory Dorsainville, James George Rheinwald;
Epithelial cells derived from human embryonic stem cells display p16INK4A senescence, hypermotility, and differentiation properties shared by many P63+ somatic cell types.
Stem Cells 27:1388-1399(2009)

Cross-references
Encyclopedic resources Wikidata; Q95991822
Entry history
Entry creation25-Feb-2019
Last entry update10-Apr-2025
Version number8