Cellosaurus cell line N/E6E7 (CVCL

Cellosaurus N/E6E7 (CVCL_UZ61)

Cross-references
Cell line name	N/E6E7
Accession	CVCL_UZ61
Resource Identification Initiative	To cite this cell line use: N/E6E7 (RRID:CVCL_UZ61)
Comments	Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6. Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7. Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo. Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16). Derived from site: In situ; Skin, epidermis; UBERON=UBERON_0001003. Cell type: Keratinocyte; CL=CL_0000312.
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_UZ57 (N)
Sex of cell	Male
Age at sampling	<1M
Category	Transformed cell line
Web pages	Provider; BWH dermatology; -; https://dermatology.bwh.harvard.edu/docs/Cell-Culture-Core-Cell-Lines.pdf
Publications	PubMed=12077343; DOI=10.1128/mcb.22.14.5157-5172.2002; PMCID=PMC139780 James George Rheinwald, William Chun Hahn, Matthew Robert Ramsey, Jenny Y. Wu, Zong-You Guo, Hensin Tsao, Michele De Luca, Caterina Catricala, Kathleen M. O'Toole; A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status. Mol. Cell. Biol. 22:5157-5172(2002) PubMed=19489101; DOI=10.1002/stem.64; PMCID=PMC2733375 Sally Dabelsteen, Paula Hercule, Patricia Barron, Meghan Rice, Gregory Dorsainville, James George Rheinwald; Epithelial cells derived from human embryonic stem cells display p16INK4A senescence, hypermotility, and differentiation properties shared by many P63+ somatic cell types. Stem Cells 27:1388-1399(2009)
Encyclopedic resources	Wikidata; Q95991843
Entry history
Entry creation	25-Feb-2019
Last entry update	14-Aug-2025
Version number	11