Cellosaurus cell line N/TERT-2 (CVCL

Cellosaurus N/TERT-2 (CVCL_UZ62)

Cross-references
Cell line name	N/TERT-2
Synonyms	N/TERT-2G; N/TERT 2G; N/TERT2G
Accession	CVCL_UZ62
Resource Identification Initiative	To cite this cell line use: N/TERT-2 (RRID:CVCL_UZ62)
Comments	Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT. Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR). Derived from site: In situ; Skin, epidermis; UBERON=UBERON_0001003. Cell type: Keratinocyte; CL=CL_0000312.
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_UZ57 (N)
Sex of cell	Male
Age at sampling	<1M
Category	Telomerase immortalized cell line
Web pages	Provider; BWH dermatology; -; https://dermatology.bwh.harvard.edu/docs/Cell-Culture-Core-Cell-Lines.pdf
Publications	PubMed=10648628; DOI=10.1128/mcb.20.4.1436-1447.2000; PMCID=PMC85304 Dickson M.A., Hahn W.C., Ino Y., Ronfard V., Wu J.Y., Weinberg R.A., Louis D.N., Li F.P., Rheinwald J.G. Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics. Mol. Cell. Biol. 20:1436-1447(2000) PubMed=28928444; DOI=10.1038/s41598-017-12041-y; PMCID=PMC5605545 Smits J.P.H., Niehues H., Rikken G., van Vlijmen-Willems I.M.J.J., van de Zande G.W.H.J.F., Zeeuwen P.L.J.M., Schalkwijk J., van den Bogaard E.H.J. Immortalized N/TERT keratinocytes as an alternative cell source in 3D human epidermal models. Sci. Rep. 7:11838-11838(2017)
Encyclopedic resources	Wikidata; Q95991849
Entry history
Entry creation	25-Feb-2019
Last entry update	10-Apr-2025
Version number	10