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Cellosaurus R2F/HTERT (CVCL_UZ36)

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Cell line name R2F/HTERT
Accession CVCL_UZ36
Resource Identification Initiative To cite this cell line use: R2F/HTERT (RRID:CVCL_UZ36)
Comments Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: In situ; Foreskin, skin, dermis; UBERON=UBERON_0001471+UBERON_0002067.
Cell type: Fibroblast of foreskin; CL=CL_1001608.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_UZ35 (R2F)
Sex of cell Male
Age at sampling <1M
Category Telomerase immortalized cell line
Web pages Provider; BWH dermatology; -; https://dermatology.bwh.harvard.edu/docs/Cell-Culture-Core-Cell-Lines.pdf
Publications

PubMed=12077343; DOI=10.1128/mcb.22.14.5157-5172.2002; PMCID=PMC139780
James George Rheinwald, William Chun Hahn, Matthew Robert Ramsey, Jenny Y. Wu, Zong-You Guo, Hensin Tsao, Michele De Luca, Caterina Catricala, Kathleen M. O'Toole;
A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status.
Mol. Cell. Biol. 22:5157-5172(2002)

Cross-references
Encyclopedic resources Wikidata; Q98128780
Entry history
Entry creation25-Feb-2019
Last entry update14-Aug-2025
Version number11