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Cellosaurus R2F (CVCL_UZ35)

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Cell line name R2F
Synonyms R2-F
Accession CVCL_UZ35
Resource Identification Initiative To cite this cell line use: R2F (RRID:CVCL_UZ35)
Comments Senescence: Senesces at 80 PDL (PubMed=12077343).
Derived from site: In situ; Foreskin, skin, dermis; UBERON=UBERON_0001471+UBERON_0002067.
Cell type: Fibroblast of foreskin; CL=CL_1001608.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_UZ36 (R2F/HTERT)
Sex of cell Male
Age at sampling <1M
Category Finite cell line
Web pages Provider; BWH dermatology; -; https://dermatology.bwh.harvard.edu/docs/Cell-Culture-Core-Cell-Lines.pdf
Publications

PubMed=3130603
Ross A. Tubo, James George Rheinwald;
Normal human mesothelial cells and fibroblasts transfected with the EJras oncogene become EGF-independent, but are not malignantly transformed.
Oncogene Res. 1:407-421(1987)

PubMed=12077343; DOI=10.1128/mcb.22.14.5157-5172.2002; PMCID=PMC139780
James George Rheinwald, William Chun Hahn, Matthew Robert Ramsey, Jenny Y. Wu, Zong-You Guo, Hensin Tsao, Michele De Luca, Caterina Catricala, Kathleen M. O'Toole;
A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status.
Mol. Cell. Biol. 22:5157-5172(2002)

PubMed=19489101; DOI=10.1002/stem.64; PMCID=PMC2733375
Sally Dabelsteen, Paula Hercule, Patricia Barron, Meghan Rice, Gregory Dorsainville, James George Rheinwald;
Epithelial cells derived from human embryonic stem cells display p16INK4A senescence, hypermotility, and differentiation properties shared by many P63+ somatic cell types.
Stem Cells 27:1388-1399(2009)

Cross-references
Encyclopedic resources Wikidata; Q98128779
Entry history
Entry creation25-Feb-2019
Last entry update10-Apr-2025
Version number8