ID   R2F/HTERT
AC   CVCL_UZ36
DR   Wikidata; Q98128780
RX   PubMed=12077343;
WW   Provider; BWH dermatology; -; https://dermatology.bwh.harvard.edu/docs/Cell-Culture-Core-Cell-Lines.pdf
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Derived from site: In situ; Foreskin, skin, dermis; UBERON=UBERON_0001471+UBERON_0002067.
CC   Cell type: Fibroblast of foreskin; CL=CL_1001608.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_UZ35 ! R2F
SX   Male
AG   <1M
CA   Telomerase immortalized cell line
DT   Created: 25-02-19; Last updated: 10-04-25; Version: 10
//
RX   PubMed=12077343; DOI=10.1128/mcb.22.14.5157-5172.2002; PMCID=PMC139780;
RA   Rheinwald J.G., Hahn W.C., Ramsey M.R., Wu J.Y., Guo Z.-Y., Tsao H.,
RA   De Luca M., Catricala C., O'Toole K.M.;
RT   "A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence
RT   mechanism that limits replicative potential independent of telomere
RT   status.";
RL   Mol. Cell. Biol. 22:5157-5172(2002).
//