Cellosaurus cell line CV-hIPS-B-APP-KO clone 1B6 (CVCL

Cross-references
Cell line name	CV-hIPS-B-APP-KO clone 1B6
Synonyms	GM25430-APP-KO clone 1B6; 1B6; APPnull in CV background
Accession	CVCL_UI22
Resource Identification Initiative	To cite this cell line use: CV-hIPS-B-APP-KO clone 1B6 (RRID:CVCL_UI22)
Comments	Population: Caucasian. Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:620; APP. Derived from site: In situ; Arm, skin; UBERON=UBERON_0002427. Cell type: Fibroblast of skin; CL=CL_0002620.
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_1N86 (CV-hIPS-B)
Sex of cell	Male
Age at sampling	62Y
Category	Induced pluripotent stem cell
Publications	PubMed=30686764; DOI=10.1016/j.stem.2018.12.013; PMCID=PMC6414424 Rik van der Kant, Vanessa F. Langness, Cheryl M. Herrera, Daniel A. Williams, Lauren K. Fong, Yves Leestemaker, Evelyne Steenvoorden, Kevin D. Rynearson, Jos F. Brouwers, J. Bernd Helms, Huib Ovaa ...Show all 15 authors... , Martin Giera, Steven L. Wagner, Anne G. Bang, Lawrence Steven B. Goldstein; Show fewer authors Cholesterol metabolism is a druggable axis that independently regulates Tau and amyloid-beta in iPSC-derived Alzheimer's disease neurons. Cell Stem Cell 24:363-375.e9(2019)
Encyclopedic resources	Wikidata; Q93460586
Entry history
Entry creation	25-Feb-2019
Last entry update	19-Dec-2024
Version number	8