ID   CV-hIPS-B-APP-KO clone 1B6
AC   CVCL_UI22
SY   GM25430-APP-KO clone 1B6; 1B6; APPnull in CV background
DR   Wikidata; Q93460586
RX   PubMed=30686764;
CC   Population: Caucasian.
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:620; APP.
CC   Derived from site: In situ; Arm, skin; UBERON=UBERON_0002427.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1N86 ! CV-hIPS-B
SX   Male
AG   62Y
CA   Induced pluripotent stem cell
DT   Created: 25-02-19; Last updated: 19-12-24; Version: 8
//
RX   PubMed=30686764; DOI=10.1016/j.stem.2018.12.013; PMCID=PMC6414424;
RA   van der Kant R., Langness V.F., Herrera C.M., Williams D.A.,
RA   Fong L.K., Leestemaker Y., Steenvoorden E., Rynearson K.D.,
RA   Brouwers J.F., Helms J.B., Ovaa H., Giera M., Wagner S.L., Bang A.G.,
RA   Goldstein L.S.B.;
RT   "Cholesterol metabolism is a druggable axis that independently
RT   regulates Tau and amyloid-beta in iPSC-derived Alzheimer's disease
RT   neurons.";
RL   Cell Stem Cell 24:363-375.e9(2019).
//